Design, synthesis, and evaluation of 4-(substituted)phenyl-2-thioxo-3,4- dihydro-1H-chromino[4,3-d]pyrimidin-5-one and 4-(substituted)phenyl-3,4-dihydro- 1H-chromino[4,3-d]pyrimidine-2,5-dione analogs as antitubercular agents

Medicinal Chemistry Research

Volumn 23, Issue 5, 2014, Pages 2564-2575

  Ambre, Premlata K ^a   Pissurlenkar, Raghuvir R S ^a   Wavhale, Ravindra D ^a   Shaikh, Mushtaque S ^a   Khedkar, Vijay M ^a   Wan, Baojie ^b   Franzblau, Scott G ^b   Coutinho, Evans C ^a  

^a BOMBAY COLLEGE OF PHARMACY   (India)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

3,4 Annelated coumarins; Antitubercular agents; LORA; MABA; Recursive partitioning (RP)

Indexed keywords

4 (2 HYDROXY)PHENYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; 4 (3 BROMO)PHENYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO [4,3 D]PYRIMIDIN 5 ONE; 4 (3 BROMO)PHENYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; 4 (3 BROMO)PHENYL 9 METHYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDIN 5 ONE; 4 (3,4 DIMETHOXY)PHENYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDIN 5 ONE; 4 (3,4 DIMETHOXY)PHENYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; 4 (3,4 DIMETHOXY)PHENYL 9 METHYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO [4,3 D]PYRIMIDIN 5 ONE; 4 (3,4 DIMETHOXY)PHENYL 9 METHYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; 4 (4 HYDROXY 3 METHOXY)PHENYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; 4 (4 HYDROXY 3 METHOXY)PHENYL 9 METHYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO [4,3 D]PYRIMIDIN 5 ONE; 4 (4 METHOXY)PHENYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; 4 (4 METHOXY)PHENYL 9 METHYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO [4,3 D]PYRIMIDIN 5 ONE; 4 (4 METHOXY)PHENYL 9 METHYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; 4 ANISYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDIN 5 ONE; 4 PHENYL 2 THIOXO 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDIN 5 ONE; 4 PHENYL 3,4 DIHYDRO 1H CHROMINO[4,3 D]PYRIMIDINE 2,5 DIONE; ALKANAL MONOOXYGENASE (FMN LINKED); OXYGEN; PYRIMIDINE DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; ASSAY; BIOREACTOR; CONTROLLED STUDY; DECISION TREE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; GREEN CHEMISTRY; LUMINESCENCE BASED LOW OXYGEN RECOVERY ASSAY; MICROPLATE ALAMAR BLUE ASSAY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMID; RESAZURIN ASSAY;

EID: 84898776937     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0850-7     Document Type: Article

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