Placenta-specific miRNA (miR-512-3p) targets PPP3R1 encoding the calcineurin B regulatory subunit in BeWo cells

Journal of Obstetrics and Gynaecology Research

Volumn 40, Issue 3, 2014, Pages 650-660

  Kurashina, Ryuhei ^a   Kikuchi, Kunio ^a   Iwaki, Jun ^a   Yoshitake, Hiroshi ^a   Takeshita, Toshiyuki ^a   Takizawa, Toshihiro ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Calcineurin; Human placenta; MiR 512 3p; MiRNA; PPP3R1

Indexed keywords

CALCINEURIN; MICRORNA; MICRORNA 1323; MICRORNA 512 3P; MICRORNA 518B; MICRORNA 520A; MICRORNA 524; UNCLASSIFIED DRUG; MIRN512 MICRORNA, HUMAN; PPP3R1 PROTEIN, HUMAN; RECOMBINANT PROTEIN;

3' UNTRANSLATED REGION; 3' UNTRANSLATED REGION REPORTER ASSAY; ARTICLE; BEWO CELL; CHORION VILLUS; CHROMOSOME 19; COMPUTER PROGRAM; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENDOTHELIUM CELL; FETUS; GENE; GENE EXPRESSION ASSAY; GENE EXPRESSION PROFILING; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; LASER MICRODISSECTION; PLACENTA; PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B ALPHA GENE; REAL TIME POLYMERASE CHAIN REACTION; STROMA CELL; TROPHOBLAST; TUMOR CELLS AND CELL LINES; WESTERN BLOTTING; ADULT; ANTIBODY SPECIFICITY; CELL LINE; CHEMISTRY; CYTOLOGY; FEMALE; GENETICS; LASER CAPTURE MICRODISSECTION; METABOLISM; PREGNANCY;

ADULT; CALCINEURIN; CELL LINE; DOWN-REGULATION; FEMALE; HUMANS; LASER CAPTURE MICRODISSECTION; MICRORNAS; ORGAN SPECIFICITY; PLACENTA; PREGNANCY; RECOMBINANT PROTEINS; TROPHOBLASTS;

EID: 84898768871     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/jog.12217     Document Type: Article

References (30)

1. Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell 2009; 136: 215-233.
2. Wu L, Belasco JG. Let me count the ways: Mechanisms of gene regulation by miRNAs and siRNAs. Mol Cell 2008; 29: 1-7.
3. van Rooij E. The art of microRNA research. Circ Res 2011; 108: 219-234.
4. Farazi TA, Spitzer JI, Morozov P, Tuschl T. miRNAs in human cancer. J Pathol 2011; 223: 102-115.
5. Park CY, Choi YS, McManus MT. Analysis of microRNA knockouts in mice. Hum Mol Gen 2010; 19: R169-R175.
6. Landgraf P, Rusu M, Sheridan R et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007; 129: 1401-1414.
7. Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-355.
8. Ason B, Darnell DK, Wittbrodt B et al. Differences in vertebrate microRNA expression. Proc Natl Acad Sci U S A 2006; 103: 14385-14389.
9. Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-450.
10. Wienholds E, Plasterk RH. MicroRNA function in animal development. FEBS Lett 2005; 579: 5911-5922.
11. Bentwich I, Avniel A, Karov Y et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet 2005; 37: 766-770.
12. Luo SS, Ishibashi O, Ishikawa G et al. Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes. Biol Reprod 2009; 81: 717-729.
13. Bortolin-Cavaille ML, Dance M, Weber M, Cavaille J. C19MC microRNAs are processed from introns of large Pol-II, nonprotein-coding transcripts. Nucl Acids Res 2009; 37: 3464-3473.
14. Noguer-Dance M, Abu-Amero S, Al-Khtib M et al. The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta. Hum Mol Gen 2010; 19: 3566-3582.
15. Donker RB, Mouillet JF, Chu T et al. The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes. Mol Hum Reprod 2012; 18: 417-424.
16. Morales-Prieto DM, Chaiwangyen W, Ospina-Prieto S et al. MicroRNA expression profiles of trophoblastic cells. Placenta 2012; 33: 725-734.
17. Zhang R, Wang YQ, Su B. Molecular evolution of a primatespecific microRNA family. Mol Biol Evol 2008; 25: 1493-1502.
18. Ishibashi O, Ohkuchi A, Ali MM et al. Hydroxysteroid (17-beta) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: A novel marker for predicting preeclampsia. Hypertension 2012; 59: 265-273.
19. Xia Y, Wen HY, Kellems RE. Angiotensin II inhibits human trophoblast invasion through AT1 receptor activation. J Bio Chem 2002; 277: 24601-24608.
20. Zhou CC, Ahmad S, Mi T et al. Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy. Circ Res 2007; 100: 88-95.
21. Zhou CC, Ahmad S, Mi T et al. Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension 2008; 51: 1010-1019.
22. Fornari F, Milazzo M, Chieco P et al. In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. J Pathol 2012; 227: 275-285.
23. Huang Q, Gumireddy K, Schrier M et al. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol 2008; 10: 202-210.
24. Yang K, Handorean AM, Iczkowski KA. MicroRNAs 373 and 520c are downregulated in prostate cancer, suppress CD44 translation and enhance invasion of prostate cancer cells in vitro. Int J Clin Exp Pathol 2009; 2: 361-369.
25. Iczkowski KA. Cell adhesion molecule CD44: Its functional roles in prostate cancer. Am J Trans Res 2010; 3: 1-7.
26. Liu P, Wilson MJ. miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-kappaB factor in human fibrosarcoma cells. J Cell Physiol 2012; 227: 867-876.
27. Musson RE, Cobbaert CM, Smit NP. Molecular diagnostics of calcineurin-related pathologies. Clin Chem 2012; 58: 511-522.
28. Rusnak F, Mertz P. Calcineurin: Form and function. Physiol Rev 2000; 80: 1483-1521.
29. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: Regulation and function. Annu Rev Immunol 1997; 15: 707-747.
30. Weiland M, Gao XH, Zhou L, Mi QS. Small RNAs have a large impact: Circulating microRNAs as biomarkers for human diseases. RNA Biol 2012; 9: 850-859.