-
3
-
-
78649231563
-
Challenges and solutions to metabolites in safety testing: Impact of the International Conference on Harmonization M3(R2) guidance
-
Yu H, Bischoff D, Tweedie D. Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance. Expert Opin. Drug Metab. Toxixol. 6(12), 1539-1549 (2010).
-
(2010)
Expert Opin. Drug Metab. Toxixol.
, vol.6
, Issue.12
, pp. 1539-1549
-
-
Yu, H.1
Bischoff, D.2
Tweedie, D.3
-
4
-
-
62249135160
-
Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials
-
Baillie TA. Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials. Chem. Res. Toxicol. 22(2), 263-266 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, Issue.2
, pp. 263-266
-
-
Baillie, T.A.1
-
5
-
-
78650423579
-
Determination of exposure multiples of human metabolites for MIST assessment in preclinical safety species without using reference standards or radiolabeled compounds
-
Ma S, Li Z, Lee KJ, Chowdhury SK. Determination of exposure multiples of human metabolites for MIST assessment in preclinical safety species without using reference standards or radiolabeled compounds. Chem. Res. Toxicol. 23(12), 1871-1873 (2010).
-
(2010)
Chem. Res. Toxicol.
, vol.23
, Issue.12
, pp. 1871-1873
-
-
Ma, S.1
Li, Z.2
Lee, K.J.3
Chowdhury, S.K.4
-
6
-
-
84855272978
-
Evaluation of relative LC-MS response of metabolites to parent drug in LC/nanospray ionization mass spectrometry: Potential implications in MIST assessment
-
Schadt S, Chen L-Z, Bischoff D. Evaluation of relative LC-MS response of metabolites to parent drug in LC/nanospray ionization mass spectrometry: potential implications in MIST assessment. J. Mass Spectrom. 46(12), 1282-1287 (2011).
-
(2011)
J. Mass Spectrom.
, vol.46
, Issue.12
, pp. 1282-1287
-
-
Schadt, S.1
Chen, L.-Z.2
Bischoff, D.3
-
7
-
-
78649628659
-
A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments
-
Gao H, Deng S, Obach RS. A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments. Drug Metab. Dispos. 38(12), 2147-2156 (2010).
-
(2010)
Drug Metab. Dispos.
, vol.38
, Issue.12
, pp. 2147-2156
-
-
Gao, H.1
Deng, S.2
Obach, R.S.3
-
8
-
-
34249721558
-
E, Wagrowski-Diehl DM, Lu Z, Mazzeo JR. Systematic and comprehensive strategy for reducing matrix effects in LC-MS/MS analyses
-
Chambers
-
Chambers E, Wagrowski-Diehl DM, Lu Z, Mazzeo JR. Systematic and comprehensive strategy for reducing matrix effects in LC-MS/MS analyses. J. Chromatogr. B 852(1-2), 22-34 (2007).
-
(2007)
J. Chromatogr. B
, vol.852
, Issue.1-2
, pp. 22-34
-
-
-
9
-
-
79951750007
-
Elimination of LC-MS/MS matrix effect due to phospholipids using specific solid-phase extraction elution conditions
-
Lahaie M, Mess J-N, Furtado M, Garofolo F. Elimination of LC-MS/MS matrix effect due to phospholipids using specific solid-phase extraction elution conditions. Bioanalysis 2(6), 1011-1021 (2010).
-
(2010)
Bioanalysis
, vol.2
, Issue.6
, pp. 1011-1021
-
-
Lahaie, M.1
Mess, J.-N.2
Furtado, M.3
Garofolo, F.4
-
10
-
-
0037663202
-
Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC?MS/MS
-
Matuszewski BK, Constanzer ML, Chavez-Eng CM. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC?MS/MS. Anal. Chem. 75(13), 3019-3030 (2003).
-
(2003)
Anal. Chem.
, vol.75
, Issue.13
, pp. 3019-3030
-
-
Matuszewski, B.K.1
Constanzer, M.L.2
Chavez-Eng, C.M.3
-
11
-
-
84859960927
-
Efficacy of plasma phospholipid removal during sample preparation and subsequent retention under typical UHPLC conditions
-
Neville D, Houghton R, Garrett S. Efficacy of plasma phospholipid removal during sample preparation and subsequent retention under typical UHPLC conditions. Bioanalysis 4(7), 795-807 (2012).
-
(2012)
Bioanalysis
, vol.4
, Issue.7
, pp. 795-807
-
-
Neville, D.1
Houghton, R.2
Garrett, S.3
-
12
-
-
34247843033
-
Key elements of bioanalytical method validation for small molecules
-
Bansal S, DeStefano A. Key elements of bioanalytical method validation for small molecules. AAPS J. 9(1), E109-E114 (2007).
-
(2007)
AAPS J.
, vol.9
, Issue.1
-
-
Bansal, S.1
Destefano, A.2
-
13
-
-
84898735034
-
-
ChemAxon. Chemicalize.
-
ChemAxon. Chemicalize. www.chemicalize.org
-
-
-
-
14
-
-
67650357558
-
Phospholipids in liquid chromatography-mass spectrometry bioanalysis: Comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects
-
Xia Y-Q, Jemal M. Phospholipids in liquid chromatography-mass spectrometry bioanalysis: comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects. Rapid Commun. Mass Spectrom. 23(14), 2125-2138 (2009).
-
(2009)
Rapid Commun. Mass Spectrom.
, vol.23
, Issue.14
, pp. 2125-2138
-
-
Xia, Y.-Q.1
Jemal, M.2
-
15
-
-
33645224920
-
Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma
-
Little JL, Wempe MF, Buchanan CM. Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: examining lipid matrix ionization effects in plasma. J. Chromatogr. B 833(2), 219-230 (2006).
-
(2006)
J. Chromatogr. B
, vol.833
, Issue.2
, pp. 219-230
-
-
Little, J.L.1
Wempe, M.F.2
Buchanan, C.M.3
-
16
-
-
0032566565
-
Development of high-performance liquid chromatography-tandem mass spectrometric methods for the determination of a new oxytocin receptor antagonist (L-368,899) extracted from human plasma and urine: A case of lack of specificity due to the presence of metabolites
-
Matuszewski BK, Chavez CM, Constanzer ML. Development of high-performance liquid chromatography-tandem mass spectrometric methods for the determination of a new oxytocin receptor antagonist (L-368,899) extracted from human plasma and urine: a case of lack of specificity due to the presence of metabolites. J. Chromtogr. B 716, 195-208 (1998).
-
(1998)
J. Chromtogr. B
, vol.716
, pp. 195-208
-
-
Matuszewski, B.K.1
Chavez, C.M.2
Constanzer, M.L.3
-
17
-
-
27944457524
-
Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry
-
Yan Z, Maher N, Torres R, Caldwell GW, Huebert N. Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 19(22), 3322-3330 (2005).
-
(2005)
Rapid Commun. Mass Spectrom.
, vol.19
, Issue.22
, pp. 3322-3330
-
-
Yan, Z.1
Maher, N.2
Torres, R.3
Caldwell, G.W.4
Huebert, N.5
-
18
-
-
84867538472
-
High-resolution isotope-dilution mass spectrometry using metabolism of isotope-labeled compounds: Application to drug metabolites
-
Vrbanac JJ, Hilgers A, Dubnicka T, Shilliday FB, Humphries D, Hayes RN. High-resolution isotope-dilution mass spectrometry using metabolism of isotope-labeled compounds: application to drug metabolites. Rapid Commun. Mass Spectrom. 26(22), 2569-2576 (2012).
-
(2012)
Rapid Commun. Mass Spectrom.
, vol.26
, Issue.22
, pp. 2569-2576
-
-
Vrbanac, J.J.1
Hilgers, A.2
Dubnicka, T.3
Shilliday, F.B.4
Humphries, D.5
Hayes, R.N.6
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