High-resolution isotope-dilution mass spectrometry using metabolism of isotope-labeled compounds: Application to drug metabolites

Rapid Communications in Mass Spectrometry

Volumn 26, Issue 22, 2012, Pages 2569-2576

  Vrbanac, J James ^a   Hilgers, Allen ^a   Dubnicka, Tyson ^a   Shilliday, F Barclay ^a   Humphries, David ^a   Hayes, Roger N ^a  

^a MPI RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN); SAFETY TESTING;

DICLOFENAC; DRUG METABOLITES; HIGH RESOLUTION; HUMAN PLASMAS; IN-VITRO; ISOTOPE DILUTION MASS SPECTROMETRY; ISOTOPE DILUTIONS; MASS DEFECT; QUANTITATIVE METHOD; TESTOSTERONE;

METABOLISM;

EID: 84867538472     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.6376     Document Type: Review

References (15)

1. C. C. Sweeley, W. H. Elliott, I. Fries, R. Ryhage,. Mass spectrometric determination of unresolved components in gas chromatographic effluents. Anal. Chem. 1966, 38, 1549.
2. J. F. Pickup, K. McPherson,. Theoretical considerations in stable isotope dilution mass spectrometry for organic analysis. Anal. Chem. 1976, 48, 1885.
3. Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS), (Eds:, M. Sargent, C. Harrington, R. Harte,). The Royal Society of Chemistry, Cambridge, 2002.
4. I. A. Blair, S. E. Barrow, K. A. Waddell, P. J. Lewis, C. T. Dollery,. Prostacyclin is not a circulating hormone in man. Prostaglandins 1982, 23, 579.
5. T. Santa,. Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry. Biomed. Chromatogr. 2011, 25, 1.
6. S. Gao, Z.-P. Zhanga, H. T. Karnesa,. Review: Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives. J. Chromatogr. B 2005, 825, 98.
7. W. E. Stephens,. A pulsed mass spectrometer with time dispersion. Phys. Rev. 1946, 69, 691.
8. V. M. Doroshenko, R. J. Cotter,. Ideal velocity focusing in a reflectron time-of-flight mass spectrometer. J. Am. Soc. Mass Spectrom. 1999, 10, 992.
9. B. A. Mamyrin, V. I. Karataev, D. V. Shmikk, V. A. Zagulin,. The mass-reflectron, a new nonmagnetic time-of-flight mass spectrometer with high resolution. J. Exp. Theor. Phys. 1973, 37, 45.
10. A. Makarov,. Electrostatic axially harmonic orbital trapping: A high-performance technique of mass analysis. Anal. Chem. 2000, 72, 1156.
11. Q. Hu, R. J. Noll, H. Li, A. Makarov, M. Hardmanc, R. G. Cooks,. The Orbitrap: a new mass spectrometer. J. Mass Spectrom. 2005, 40, 430.
12. Guidance for Industry: Safety Testing of Drug Metabolites. CDER, 2008.
13. J. G. Slatter, in Biotransformation and Metabolite Elucidation of Xenobiotics, (Ed:, A.F. Nassar,). John Wiley, New Jersey, 2010, pp. 295-312.
14. U. S. Food and Drug Administration. Guidance for Industry: Safety Testing of Drug Metabolites, 2008. Available: http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/ucm079266.pdf.
15. International Conference on Harmonisation. Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals M3(R2), 2009. Available: http://private.ich.org/LOB/media/ MEDIA5544.pdf.