Salvianolate inhibits reactive oxygen species production in H 2O2-treated mouse cardiomyocytes in vitro via the TGFβ pathway

Acta Pharmacologica Sinica

Volumn 34, Issue 4, 2013, Pages 496-500

  Fei, Ai Hua ^a   Cao, Qing ^b   Chen, Shu Yan ^b   Wang, Hai Rong ^a   Wang, Fei Long ^a   Pan, Shu Ming ^a   Lin, Zhao Fen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cardiac fibrosis; Cardiomyocytes; iNOS; NO; Reactive oxygen species; Salvia miltiorrhiza Bunge; Salvianolate; Smad2 3; TGF 1

Indexed keywords

ANTIOXIDANT; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; SALVIANOLATE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG INHIBITION; HEART MUSCLE CELL; IN VITRO STUDY; MOUSE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; HYDROGEN PEROXIDE; MICE; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84877274533     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.209     Document Type: Article

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