Placental transfer of 125Iodinated humanized immunoglobulin G2Δa in the Sprague Dawley rat

Reproductive Toxicology

Volumn 38, Issue , 2013, Pages 37-46

  Coder, P S ^a   Thomas, J A ^a   Stedman, D B ^b   Bowman, C J ^b  

^a WIL RESEARCH LABORATORIES   (United States)

^b PFIZER INC   (United States)

Author keywords

Biopharmaceuticals; FcRn; Immunoglobulin (IgG); Placental transfer; Pregnancy; Whole body autoradiography

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN G2A ANTIBODY I 125; RADIOPHARMACEUTICAL AGENT; TRICHLOROACETIC ACID; UNCLASSIFIED DRUG;

ACID PRECIPITATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; EMBRYO; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FEMALE; NONHUMAN; ORGANOGENESIS; PLACENTAL TRANSFER; PREGNANCY; RADIOACTIVITY; RAT; TISSUE DISTRIBUTION;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; AUTORADIOGRAPHY; EMBRYO, MAMMALIAN; FEMALE; FETUS; IMMUNOGLOBULIN G; IODINE RADIOISOTOPES; MATERNAL-FETAL EXCHANGE; PLACENTA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84875235495     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2013.02.007     Document Type: Article

References (38)

1. Pacifici G.M., Nottoli R. Placental transfer of drugs administered to the mother. Clinical Pharmacokinetics 1995, 28:235-269.
2. Roopenian D.C., Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nature Reviews Immunology 2007, 7:715-725.
3. Kim J., Mohanty S., Ganesan L.P., Hua K., Jarjoura D., Hayton W.L., et al. FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus. Journal of Immunology 2009, 182:2583-2589.
4. Roberts D.M., Guenthert M., Rodewald R. Isolation and characterization of the Fc receptor from the fetal yolk sac of the rat. Journal of Cell Biology 1990, 111:1867-1876.
5. DeSesso J.M., Williams A.L., Ahuja A., Bowman C.J., Hurtt M.E. The placenta, transfer of immunoglobulins, and safety assessment of biopharmaceuticals in pregnancy. Critical Reviews in Toxicology 2012, 42:185-210.
6. Pentsuk N., Van der Laan J.W. An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies. Birth Defects Research: Part B, Developmental and Reproductive Toxicology 2009, 86:328-344.
7. Malek A., Sager R., Kuhn P., Nicolaides K.H., Schneider H. Evolution of maternofetal transport of immunoglobulins during human pregnancy. American Journal of Reproductive Immunology 1996, 36:248-255.
8. Fujimoto K., Terao K., Cho F., Honjo S. The placental transfer of IgG in the cynomolgus monkey. Japanese Journal of Medical Science and Biology 1983, 36:171-176.
9. Martin P.L., Weinbauer G.F. Developmental toxicity testing of biopharmaceuticals in nonhuman primates: previous experience and future directions. International Journal of Toxicology 2010, 29:552-568.
10. Coe C.L., Lubach G.R., Izard K.M. Progressive improvement in the transfer of maternal antibody across the order primates. American Journal of Primatology 1994, 32:51-55.
11. Morphis L.G., Gitlin D. Maturation of the maternofoetal transport system for human gamma-globulin in the mouse. Nature 1970, 228:573.
12. Bowman C.J., King L.E., Stedman D.B. Embryo-fetal distribution of a biopharmaceutical IgG2 during rat organogenesis. Reproductive Toxicology 2012, 34:66-72.
13. Parr E.L., Parr M.B. Localization of immunoglobulins in the mouse uterus, embryo, and placenta during the second half of pregnancy. Journal of Reproductive Immunology 1985, 8:153-171.
14. USFDA Drug Approval Package-Avastin 2004.
15. Martin P.L., Sachs C., Hoberman A., Jiao Q., Bugelski P.J. Effects of CNTO 530, an erythropoietin mimetic-IgG4 fusion protein, on embryofetal development in rats and rabbits. Birth Defects Research: Part B, Developmental and Reproductive Toxicology 2010, 89:87-96.
16. Thorn M., Piche-Nicholas N., Stedman D., Davenport S.W., Zhang N., Collinge M., Bowman C.J. Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding. Birth Defects Research: Part B, Developmental and Reproductive 2012, 95:363-375.
17. Armour K.L., Atherton A., Williamson L.M., Clark M.R. The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors. Biochemical Society Transactions 2002, 30:495-500.
18. Armour K.L., Clark M.R., Hadley A.G., Williamson L.M. Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities. European Journal of Immunology 1999, 29:2613-2624.
19. Vickers T.H. The chronology of somites in rat embryos. Teratology 1983, 28:457-460.
20. Hubbard J.J., Laurenzana E.M., Williams D.K., Gentry W.B., Owens S.M. The fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats. Journal of Pharmacology and Experimental Therapeutics 2011, 336:414-422.
21. Baylis C. Glomerular filtration and volume regulation in gravid animal models. Baillieres Clinical Obstetrics and Gynaecology 1987, 1:789-813.
22. Morgan T.K., Rohrwasser A., Zhao L., Hillas E., Cheng T., Ward K.J., et al. Hypervolemia of pregnancy is not maintained in mice chronically overexpressing angiotensinogen. American Journal of Obstetrics and Gynecology 2006, 195:1700-1706.
23. Salas S.P., Rosso P., Espinoza R., Robert J.A., Valdes G., Donoso E. Maternal plasma volume expansion and hormonal changes in women with idiopathic fetal growth retardation. Obstetrics and Gynecology 1993, 81:1029-1033.
24. de Voer R.M., Van der Klis F.R., Nooitgedagt J.E., Versteegh F.G., Van Huisseling J.C., Van Rooijen D.M., et al. Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2009, 49:58-64.
25. Englund J.A., Glezen W.P., Turner C., Harvey J., Thompson C., Siber G.R. Transplacental antibody transfer following maternal immunization with polysaccharide and conjugate Haemophilus influenzae type b vaccines. The Journal of Infectious Diseases 1995, 171:99-105.
26. Garty B.Z., Ludomirsky A., Danon Y.L., Peter J.B., Douglas S.D. Placental transfer of immunoglobulin G subclasses. Clinical and Diagnostic Laboratory Immunology 1994, 1:667-669.
27. Palmeira P., Costa-Carvalho B.T., Arslanian C., Pontes G.N., Nagao A.T., Carneiro-Sampaio M.M. Transfer of antibodies across the placenta and in breast milk from mothers on intravenous immunoglobulin. Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology 2009, 20:528-535.
28. Hinton P.R., Xiong J.M., Johlfs M.G., Tang M.T., Keller S., Tsurushita N. An engineered human IgG1 antibody with longer serum half-life. Journal of Immunology 2006, 176:346-356.
29. Stapleton N.M., Andersen J.T., Stemerding A.M., Bjarnarson S.P., Verheul R.C., Gerritsen J., et al. Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential. Nature Communications 2011, 2:599.
30. West A.P., Bjorkman P.J. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. Biochemistry 2000, 39:9698-9708.
31. Goss C.M. Development of the median coordinated ventricle from the lateral hearts in rat embryos with three to six somites. The Anatomical Record 1952, 112:761-796.
32. Hood R.D. Developmental and reproductive toxicology: a practical approach 2011, Informa Healthcare, New York. 3rd ed.
33. Carney E.W., Scialli A.R., Watson R.E., DeSesso J.M. Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison. Birth Defects Research Part C: Embryo Today 2004, 72:345-360.
34. Palfi M., Selbing A. Placental transport of maternal immunoglobulin G. American Journal of Reproductive Immunology 1998, 39:24-26.
35. Gurevich P., Elhayany A., Ben-Hur H., Moldavsky M., Szvalb S., Zandbank J., et al. Secretory component J chain, and immunoglobulins in human embryos and fetuses of the first trimester of pregnancy: immunohistochemical study. Pediatric and Developmental Pathology: The Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2003, 6:35-42.
36. Gurevich P., Elhayany A., Ben-Hur H., Moldavsky M., Szvalb S., Zandbank J., et al. An immunohistochemical study of the secretory immune system in human fetal membranes and decidua of the first trimester of pregnancy. American Journal of Reproductive Immunology 2003, 50:13-19.
37. Jauniaux E., Jurkovic D., Gulbis B., Liesnard C., Lees C., Campbell S. Materno-fetal immunoglobulin transfer and passive immunity during the first trimester of human pregnancy. Human Reproduction 1995, 10:3297-3300.
38. 125I]-labeled therapeutic proteins: application in protein drug development beyond oncology. Journal of Pharmaceutical Sciences 2010, 99:1028-1045.