Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Ogawa, Nobuhiro ^a   Kawai, Hiromichi ^a   Terashima, Tomoya ^a   Kojima, Hideto ^a   Oka, Kazuhiro ^b   Chan, Lawrence ^b   Maegawa, Hiroshi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; INTERLEUKIN 6; LENTIVIRUS VECTOR; MESSENGER RNA; NEUROPEPTIDE Y; SHORT HAIRPIN RNA; SHORT HAIRPIN RNA 1; SHORT HAIRPIN RNA 2; SHORT HAIRPIN RNA 3; SHORT HAIRPIN RNA 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ATF3 PROTEIN, MOUSE; SMALL INTERFERING RNA;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATF3 GENE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; IL 6 GENE; IN VIVO STUDY; MALE; NERVE CELL NECROSIS; NEUROPATHIC PAIN; NONHUMAN; NPY GENE; NUCLEOTIDE SEQUENCE; RNA SEQUENCE; SPINAL GANGLION; TARGET ORGAN; VIRAL GENE THERAPY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL DEATH; DISEASE MODEL; GENE THERAPY; GENE VECTOR; GENETICS; LENTIVIRINAE; METABOLISM; MOUSE; NERVE CELL; NEURALGIA; PATHOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; SPINAL CORD INJURY;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; CELL DEATH; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC THERAPY; GENETIC VECTORS; INTERLEUKIN-6; LENTIVIRUS; MALE; MICE; MICE, INBRED C57BL; NEURALGIA; NEURONS; NEUROPEPTIDE Y; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84898670649     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092073     Document Type: Article

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