메뉴 건너뛰기




Volumn 241, Issue 1, 2013, Pages 159-168

The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection

Author keywords

DRG; Interleukin 6; L5 ventral root transection; Neuropathic pain; Spinal dorsal horn; TNF

Indexed keywords

INTERLEUKIN 6; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR;

EID: 84873485822     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.12.007     Document Type: Article
Times cited : (83)

References (53)
  • 1
    • 0032988286 scopus 로고    scopus 로고
    • Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey
    • Ali Z., Ringkamp M., Hartke T.V., Chien H.F., Flavahan N.A., Campbell J.N., Meyer R.A. Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J. Neurophysiol. 1999, 81:455-466.
    • (1999) J. Neurophysiol. , vol.81 , pp. 455-466
    • Ali, Z.1    Ringkamp, M.2    Hartke, T.V.3    Chien, H.F.4    Flavahan, N.A.5    Campbell, J.N.6    Meyer, R.A.7
  • 2
    • 0032570035 scopus 로고    scopus 로고
    • Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain
    • Arruda J.L., Colburn R.W., Rickman A.J., Rutkowski M.D., DeLeo J.A. Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain. Brain Res. Mol. Brain Res. 1998, 62:228-235.
    • (1998) Brain Res. Mol. Brain Res. , vol.62 , pp. 228-235
    • Arruda, J.L.1    Colburn, R.W.2    Rickman, A.J.3    Rutkowski, M.D.4    DeLeo, J.A.5
  • 3
    • 0034613224 scopus 로고    scopus 로고
    • Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain
    • Arruda J.L., Sweitzer S., Rutkowski M.D., DeLeo J.A. Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res. 2000, 879:216-225.
    • (2000) Brain Res. , vol.879 , pp. 216-225
    • Arruda, J.L.1    Sweitzer, S.2    Rutkowski, M.D.3    DeLeo, J.A.4
  • 4
    • 0021685206 scopus 로고
    • Discharge pattern of afferent fibers from a neuroma
    • Blumberg H., Janig W. Discharge pattern of afferent fibers from a neuroma. Pain 1984, 20:335-353.
    • (1984) Pain , vol.20 , pp. 335-353
    • Blumberg, H.1    Janig, W.2
  • 5
    • 0028873068 scopus 로고
    • Interleukin-6 production by Schwann cells and induction in sciatic nerve injury
    • Bolin L.M., Verity A.N., Silver J.E., Shooter E.M., Abrams J.S. Interleukin-6 production by Schwann cells and induction in sciatic nerve injury. J. Neurochem. 1995, 64:850-858.
    • (1995) J. Neurochem. , vol.64 , pp. 850-858
    • Bolin, L.M.1    Verity, A.N.2    Silver, J.E.3    Shooter, E.M.4    Abrams, J.S.5
  • 6
    • 0034814183 scopus 로고    scopus 로고
    • Nerve lesions and the generation of pain
    • Campbell J.N. Nerve lesions and the generation of pain. Muscle Nerve 2001, 24:1261-1273.
    • (2001) Muscle Nerve , vol.24 , pp. 1261-1273
    • Campbell, J.N.1
  • 8
    • 78651415886 scopus 로고    scopus 로고
    • TNF-alpha enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury
    • Chen X., Pang R.P., Shen K.F., Zimmermann M., Xin W.J., Li Y.Y., Liu X.G. TNF-alpha enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury. Exp. Neurol. 2011, 227:279-286.
    • (2011) Exp. Neurol. , vol.227 , pp. 279-286
    • Chen, X.1    Pang, R.P.2    Shen, K.F.3    Zimmermann, M.4    Xin, W.J.5    Li, Y.Y.6    Liu, X.G.7
  • 9
    • 0029783630 scopus 로고    scopus 로고
    • Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model
    • DeLeo J.A., Colburn R.W., Nichols M., Malhotra A. Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. J. Interferon Cytokine Res. 1996, 16:695-700.
    • (1996) J. Interferon Cytokine Res. , vol.16 , pp. 695-700
    • DeLeo, J.A.1    Colburn, R.W.2    Nichols, M.3    Malhotra, A.4
  • 10
    • 0000313395 scopus 로고
    • The up-and-down method for small samples
    • Dixon W. The up-and-down method for small samples. J. Am. Stat. Assoc. 1965, 60:967-978.
    • (1965) J. Am. Stat. Assoc. , vol.60 , pp. 967-978
    • Dixon, W.1
  • 11
    • 77957332761 scopus 로고    scopus 로고
    • Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model
    • Dubovy P., Klusakova I., Svizenska I., Brazda V. Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model. Neuron Glia Biol. 2010, 6:73-83.
    • (2010) Neuron Glia Biol. , vol.6 , pp. 73-83
    • Dubovy, P.1    Klusakova, I.2    Svizenska, I.3    Brazda, V.4
  • 13
    • 0029895740 scopus 로고    scopus 로고
    • Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia
    • Gadient R.A., Otten U. Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia. Brain Res. 1996, 724:41-46.
    • (1996) Brain Res. , vol.724 , pp. 41-46
    • Gadient, R.A.1    Otten, U.2
  • 14
    • 0033979426 scopus 로고    scopus 로고
    • Spinal nerve ligation: what to blame for the pain and why
    • Gold M.S. Spinal nerve ligation: what to blame for the pain and why. Pain 2000, 84:117-120.
    • (2000) Pain , vol.84 , pp. 117-120
    • Gold, M.S.1
  • 16
    • 0030598184 scopus 로고    scopus 로고
    • AFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy
    • Ji R.R., Zhang Q., Pettersson R.F., Hökfelt T. aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy. Regul. Pept. 1996, 66:179-189.
    • (1996) Regul. Pept. , vol.66 , pp. 179-189
    • Ji, R.R.1    Zhang, Q.2    Pettersson, R.F.3    Hökfelt, T.4
  • 17
    • 45549090676 scopus 로고    scopus 로고
    • Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    • Kawasaki Y., Zhang L., Cheng J.K., Ji R.R. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J. Neurosci. 2008, 28:5189-5194.
    • (2008) J. Neurosci. , vol.28 , pp. 5189-5194
    • Kawasaki, Y.1    Zhang, L.2    Cheng, J.K.3    Ji, R.R.4
  • 18
    • 49749142983 scopus 로고    scopus 로고
    • The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice
    • Kiguchi N., Maeda T., Kobayashi Y., Kondo T., Ozaki M., Kishioka S. The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice. Eur. J. Pharmacol. 2008, 592:87-92.
    • (2008) Eur. J. Pharmacol. , vol.592 , pp. 87-92
    • Kiguchi, N.1    Maeda, T.2    Kobayashi, Y.3    Kondo, T.4    Ozaki, M.5    Kishioka, S.6
  • 19
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • Kim S.H., Chung J.M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992, 50:355-363.
    • (1992) Pain , vol.50 , pp. 355-363
    • Kim, S.H.1    Chung, J.M.2
  • 20
    • 11244254104 scopus 로고    scopus 로고
    • Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model
    • Lee H.L., Lee K.M., Son S.J., Hwang S.H., Cho H.J. Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model. NeuroReport 2004, 15:2807-2811.
    • (2004) NeuroReport , vol.15 , pp. 2807-2811
    • Lee, H.L.1    Lee, K.M.2    Son, S.J.3    Hwang, S.H.4    Cho, H.J.5
  • 21
    • 67949107912 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model
    • Lee K.M., Jeon S.M., Cho H.J. Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model. Eur. J. Pain 2009, 13:794-806.
    • (2009) Eur. J. Pain , vol.13 , pp. 794-806
    • Lee, K.M.1    Jeon, S.M.2    Cho, H.J.3
  • 22
    • 0034175661 scopus 로고    scopus 로고
    • Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers
    • Li Y., Dorsi M.J., Meyer R.A., Belzberg A.J. Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers. Pain 2000, 85:493-502.
    • (2000) Pain , vol.85 , pp. 493-502
    • Li, Y.1    Dorsi, M.J.2    Meyer, R.A.3    Belzberg, A.J.4
  • 23
    • 0036244959 scopus 로고    scopus 로고
    • Effect of lumbar 5 ventral root transection on pain behaviors: a novel rat model for neuropathic pain without axotomy of primary sensory neurons
    • Li L., Xian C.J., Zhong J.H., Zhou X.F. Effect of lumbar 5 ventral root transection on pain behaviors: a novel rat model for neuropathic pain without axotomy of primary sensory neurons. Exp. Neurol. 2002, 175:23-34.
    • (2002) Exp. Neurol. , vol.175 , pp. 23-34
    • Li, L.1    Xian, C.J.2    Zhong, J.H.3    Zhou, X.F.4
  • 24
    • 0033957307 scopus 로고    scopus 로고
    • Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats
    • Liu X., Eschenfelder S., Blenk K.H., Janig W., Habler H. Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. Pain 2000, 84:309-318.
    • (2000) Pain , vol.84 , pp. 309-318
    • Liu, X.1    Eschenfelder, S.2    Blenk, K.H.3    Janig, W.4    Habler, H.5
  • 25
    • 0032826994 scopus 로고    scopus 로고
    • Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors
    • Marz P., Otten U., Rose-John S. Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors. Eur. J. Neurosci. 1999, 11:2995-3004.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 2995-3004
    • Marz, P.1    Otten, U.2    Rose-John, S.3
  • 26
    • 0034175624 scopus 로고    scopus 로고
    • Axotomized and intact muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion
    • Michaelis M., Liu X., Janig W. Axotomized and intact muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion. J. Neurosci. 2000, 20:2742-2748.
    • (2000) J. Neurosci. , vol.20 , pp. 2742-2748
    • Michaelis, M.1    Liu, X.2    Janig, W.3
  • 27
    • 33745153343 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms in neuropathic pain
    • Moalem G., Tracey D.J. Immune and inflammatory mechanisms in neuropathic pain. Brain Res. Rev. 2006, 51:240-264.
    • (2006) Brain Res. Rev. , vol.51 , pp. 240-264
    • Moalem, G.1    Tracey, D.J.2
  • 28
    • 0027230553 scopus 로고
    • Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
    • Moreira A.L., Sampaio E.P., Zmuidzinas A., Frindt P., Smith K.A., Kaplan G. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J. Exp. Med. 1993, 177:1675-1680.
    • (1993) J. Exp. Med. , vol.177 , pp. 1675-1680
    • Moreira, A.L.1    Sampaio, E.P.2    Zmuidzinas, A.3    Frindt, P.4    Smith, K.A.5    Kaplan, G.6
  • 29
    • 0033562393 scopus 로고    scopus 로고
    • Nature of the retrograde signal from injured nerves that induces interleukin-6 mRNA in neurons
    • Murphy P.G., Borthwick L.S., Johnston R.S., Kuchel G., Richardson P.M. Nature of the retrograde signal from injured nerves that induces interleukin-6 mRNA in neurons. J. Neurosci. 1999, 19:3791-3800.
    • (1999) J. Neurosci. , vol.19 , pp. 3791-3800
    • Murphy, P.G.1    Borthwick, L.S.2    Johnston, R.S.3    Kuchel, G.4    Richardson, P.M.5
  • 30
    • 0032968705 scopus 로고    scopus 로고
    • Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice
    • Murphy P.G., Ramer M.S., Borthwick L., Gauldie J., Richardson P.M., Bisby M.A. Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice. Eur. J. Neurosci. 1999, 11:2243-2253.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 2243-2253
    • Murphy, P.G.1    Ramer, M.S.2    Borthwick, L.3    Gauldie, J.4    Richardson, P.M.5    Bisby, M.A.6
  • 32
    • 0029075998 scopus 로고
    • Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats
    • Oka T., Oka K., Hosoi M., Hori T. Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats. Brain Res. 1995, 692:123-128.
    • (1995) Brain Res. , vol.692 , pp. 123-128
    • Oka, T.1    Oka, K.2    Hosoi, M.3    Hori, T.4
  • 33
    • 0031795813 scopus 로고    scopus 로고
    • Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice
    • Ramer M.S., Murphy P.G., Richardson P.M., Bisby M.A. Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice. Pain 1998, 78:115-121.
    • (1998) Pain , vol.78 , pp. 115-121
    • Ramer, M.S.1    Murphy, P.G.2    Richardson, P.M.3    Bisby, M.A.4
  • 34
    • 0026080801 scopus 로고
    • Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
    • Sampaio E.P., Sarno E.N., Galilly R., Cohn Z.A., Kaplan G. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J. Exp. Med. 1991, 173:699-703.
    • (1991) J. Exp. Med. , vol.173 , pp. 699-703
    • Sampaio, E.P.1    Sarno, E.N.2    Galilly, R.3    Cohn, Z.A.4    Kaplan, G.5
  • 35
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: neurons, immune cells and glia
    • Scholz J., Woolf C.J. The neuropathic pain triad: neurons, immune cells and glia. Nat. Neurosci. 2007, 10:1361-1368.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1361-1368
    • Scholz, J.1    Woolf, C.J.2
  • 36
    • 34249680790 scopus 로고    scopus 로고
    • Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain
    • Uceyler N., Tscharke A., Sommer C. Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain. Brain Behav. Immun. 2007, 21:553-560.
    • (2007) Brain Behav. Immun. , vol.21 , pp. 553-560
    • Uceyler, N.1    Tscharke, A.2    Sommer, C.3
  • 37
    • 0034668173 scopus 로고    scopus 로고
    • Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6
    • Vanden Berghe W., Vermeulen L., De Wilde G., De Bosscher K., Boone E., Haegeman G. Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. Biochem. Pharmacol. 2000, 60:1185-1195.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1185-1195
    • Vanden Berghe, W.1    Vermeulen, L.2    De Wilde, G.3    De Bosscher, K.4    Boone, E.5    Haegeman, G.6
  • 40
    • 18144410985 scopus 로고    scopus 로고
    • Exogenous interleukin-6 increases cold allodynia in rats with a mononeuropathy
    • Vissers K.C., De Jongh R.F., Hoffmann V.L., Meert T.F. Exogenous interleukin-6 increases cold allodynia in rats with a mononeuropathy. Cytokine 2005, 30:154-159.
    • (2005) Cytokine , vol.30 , pp. 154-159
    • Vissers, K.C.1    De Jongh, R.F.2    Hoffmann, V.L.3    Meert, T.F.4
  • 41
    • 0016370440 scopus 로고
    • Ongoing activity in peripheral nerve: injury discharge
    • Wall P.D., Waxman S., Basbaum A.I. Ongoing activity in peripheral nerve: injury discharge. Exp. Neurol. 1974, 45:576-589.
    • (1974) Exp. Neurol. , vol.45 , pp. 576-589
    • Wall, P.D.1    Waxman, S.2    Basbaum, A.I.3
  • 42
    • 0344305586 scopus 로고    scopus 로고
    • The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in rats
    • Watanabe C., Sakurada T., Okuda K., Sakurada C., Ando R., Sakurada S. The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in rats. Pain 2003, 106:269-283.
    • (2003) Pain , vol.106 , pp. 269-283
    • Watanabe, C.1    Sakurada, T.2    Okuda, K.3    Sakurada, C.4    Ando, R.5    Sakurada, S.6
  • 43
    • 34248572468 scopus 로고    scopus 로고
    • Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway
    • Wei X.H., Zang Y., Wu C.Y., Xu J.T., Xin W.J., Liu X.G. Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway. Exp. Neurol. 2007, 205:471-484.
    • (2007) Exp. Neurol. , vol.205 , pp. 471-484
    • Wei, X.H.1    Zang, Y.2    Wu, C.Y.3    Xu, J.T.4    Xin, W.J.5    Liu, X.G.6
  • 48
    • 0031441582 scopus 로고    scopus 로고
    • Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section
    • Xu X.J., Hao J.X., Andell-Jonsson S., Poli V., Bartfai T., Wiesenfeld-Hallin Z. Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section. Cytokine 1997, 9:1028-1033.
    • (1997) Cytokine , vol.9 , pp. 1028-1033
    • Xu, X.J.1    Hao, J.X.2    Andell-Jonsson, S.3    Poli, V.4    Bartfai, T.5    Wiesenfeld-Hallin, Z.6
  • 49
    • 33745700149 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat
    • Xu J.T., Xin W.J., Zang Y., Wu C.Y., Liu X.G. The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat. Pain 2006, 123:306-321.
    • (2006) Pain , vol.123 , pp. 306-321
    • Xu, J.T.1    Xin, W.J.2    Zang, Y.3    Wu, C.Y.4    Liu, X.G.5
  • 50
    • 33847325194 scopus 로고    scopus 로고
    • P38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury
    • Xu J.T., Xin W.J., Wei X.H., Wu C.Y., Ge Y.X., Liu Y.L., Zang Y., Zhang T., Li Y.Y., Liu X.G. p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury. Exp. Neurol. 2007, 204:355-365.
    • (2007) Exp. Neurol. , vol.204 , pp. 355-365
    • Xu, J.T.1    Xin, W.J.2    Wei, X.H.3    Wu, C.Y.4    Ge, Y.X.5    Liu, Y.L.6    Zang, Y.7    Zhang, T.8    Li, Y.Y.9    Liu, X.G.10
  • 51
    • 78149466023 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro
    • Zang Y., He X.H., Xin W.J., Pang R.P., Wei X.H., Zhou L.J., Li Y.Y., Liu X.G. Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro. Brain Res. 2010, 1363:151-158.
    • (2010) Brain Res. , vol.1363 , pp. 151-158
    • Zang, Y.1    He, X.H.2    Xin, W.J.3    Pang, R.P.4    Wei, X.H.5    Zhou, L.J.6    Li, Y.Y.7    Liu, X.G.8
  • 52
    • 0033153020 scopus 로고    scopus 로고
    • Sensory impairments and delayed regeneration of sensory axons in interleukin-6-deficient mice
    • Zhong J., Dietzel I.D., Wahle P., Kopf M., Heumann R. Sensory impairments and delayed regeneration of sensory axons in interleukin-6-deficient mice. J. Neurosci. 1999, 19:4305-4313.
    • (1999) J. Neurosci. , vol.19 , pp. 4305-4313
    • Zhong, J.1    Dietzel, I.D.2    Wahle, P.3    Kopf, M.4    Heumann, R.5
  • 53
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.