Early MEK1/2 inhibition after global cerebral ischemia in rats reduces brain damage and improves outcome by preventing delayed vasoconstrictor receptor upregulation

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Johansson, Sara Ellinor ^a   Larsen, Stine Schmidt ^a   Povlsen, Gro Klitgaard ^a   Edvinsson, Lars ^a,b  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ENDOTHELIN B RECEPTOR; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; SEROTONIN 1B RECEPTOR; 1,3 BUTADIENE DERIVATIVE; NITRILE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN PERFUSION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITION; EXPERIMENTAL BEHAVIORAL TEST; GRIP STRENGHT TEST; NERVE CELL NECROSIS; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR UPREGULATION; ROTATING POLE TEST; SENSORIMOTOR FUNCTION; SHAM PROCEDURE; SURVIVAL RATE; VASOCONSTRICTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CIRCULATION; DRUG EFFECTS; DRUG SCREENING; GENETICS; HYPOXIA, BRAIN; METABOLISM; PATHOLOGY; TREATMENT OUTCOME; UPREGULATION; WISTAR RAT;

ANIMALS; BRAIN ISCHEMIA; BUTADIENES; CEREBROVASCULAR CIRCULATION; DRUG EVALUATION, PRECLINICAL; HYPOXIA, BRAIN; MAP KINASE KINASE 1; MAP KINASE KINASE 2; NITRILES; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN B; RECEPTOR, SEROTONIN, 5-HT1B; TREATMENT OUTCOME; UP-REGULATION; VASOCONSTRICTION;

EID: 84898669982     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092417     Document Type: Article

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