E2∼Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis

EMBO Journal

Volumn 33, Issue 5, 2014, Pages 437-449

  Pruneda, Jonathan N ^a,d   Smith, F Donelson ^a   Daurie, Angela ^b   Swaney, Danielle L ^c   Villén, Judit ^c   Scott, John D ^a   Stadnyk, Andrew W ^b   Le Trong, Isolde ^c   Stenkamp, Ronald E ^a,c   Klevit, Rachel E ^a   Rohde, John R ^b   Brzovic, Peter S ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY OF WASHINGTON   (United States)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

bacterial effector; E2 Ub conjugating enzyme; kinase; Shigella; ubiquitin

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE; PROTEIN OSPG; UBIQUITIN CONJUGATING ENZYME E2; UNCLASSIFIED DRUG; UBE2D3 PROTEIN, HUMAN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; VIRULENCE FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL STRAIN CACO 2; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STABILITY; FEMALE; HELA CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHIGELLA; SHIGELLOSIS; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SHIGELLA FLEXNERI; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN MULTIMERIZATION; SHIGELLA FLEXNERI; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; VIRULENCE FACTORS;

EID: 84898660353     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201386386     Document Type: Article

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