Structural basis for inactivation of Giardia lamblia carbamate Kinase by disulfiram

Journal of Biological Chemistry

Volumn 289, Issue 15, 2014, Pages 10502-10509

  Galkin, Andrey ^a   Kulakova, Liudmila ^a   Lim, Kap ^a   Chen, Catherine Z ^b   Zheng, Wei ^b   Turko, Illarion V ^a,c   Herzberg, Osnat ^a,d  

^a UNIVERSITY OF MARYLAND   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^d University of Maryland   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYME INHIBITION; MASS SPECTROMETRY;

ATP-BINDING SITE; CARBAMOYL PHOSPHATES; CONFORMATIONAL TRANSITIONS; GIARDIA LAMBLIA; IRREVERSIBLE INACTIVATION; RESISTANCE MECHANISMS; STRUCTURAL BASIS; TRYPSIN DIGESTION;

DRUG THERAPY;

ADENINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBAMATE KINASE; DISULFIRAM; METRONIDAZOLE; THIRAM; TRYPSIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CARBAMOYLATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG REPOSITIONING; DRUG TARGETING; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME STRUCTURE; FEMALE; GIARDIA LAMBLIA; GIARDIASIS; IN VIVO STUDY; MASS SPECTROMETRY; MICROBIAL VIABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANIMAL MODELS; CARBAMATE KINASE; CRYSTALLOGRAPHY; DISULFIRAM; DRUG DISCOVERY; ENZYME INHIBITORS; ENZYME STRUCTURE; GIARDIA LAMBLIA; PARASITE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIPROTOZOAL AGENTS; CATALYTIC DOMAIN; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISULFIRAM; DRUG RESISTANCE; ENZYME INHIBITORS; FEMALE; GIARDIA LAMBLIA; GIARDIASIS; MASS SPECTROMETRY; METRONIDAZOLE; MICE; MICE, INBRED C57BL; PHOSPHOTRANSFERASES (CARBOXYL GROUP ACCEPTOR); TROPHOZOITES; TRYPSIN;

EID: 84898655868     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.553123     Document Type: Article

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