A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children

Current Medical Research and Opinion

Volumn 22, Issue 11, 2006, Pages 2131-2136

  Cañete, Roberte ^a,b   Escobedo, Angel A ^c   González, Maria Elena ^a   Almirall, Pedro ^d   Cantelar, Nereyda ^e  

^a INSTITUTO DE GASTROENTEROLOGÍA   (Cuba)

^b INSTITUTO NACIONAL DE HIGIENE   (Cuba)

^c Academic Pediatric Hospital 'Pedro Borras'   (Cuba)

^d Carlos J Finlay Hospital   (Cuba)

^e INSTITUTO DE MEDICINA TROPICAL PEDRO KOURÍ   (Cuba)

Author keywords

Benzimidazoles; Children; Giardia duodenalis; Mebendazole; Tinidazole

Indexed keywords

MEBENDAZOLE; TINIDAZOLE;

ABDOMINAL PAIN; ADOLESCENT; ANOREXIA; ARTICLE; BITTER TASTE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYST; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FECES ANALYSIS; FEMALE; GIARDIA DUODENALIS; GIARDIASIS; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; TREATMENT RESPONSE; TROPHOZOITE; VOMITING;

ADOLESCENT; ANTIPROTOZOAL AGENTS; CHILD; DRUG ADMINISTRATION SCHEDULE; FECES; FEMALE; GIARDIASIS; HUMANS; MALE; MEBENDAZOLE; TINIDAZOLE; TREATMENT OUTCOME;

EID: 33751254729     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079906X132497     Document Type: Article

References (35)

1. Mariante RM, Vancini RG, Melo AL, et al. Giardia lamblia: evaluation of the in vitro effects of nocodazole and colchicines on trophozoites. Exp Parasitol 2005;110:62-72
2. Eckmann L. Mucosal defences against Giardia. Parasite Immunol 2003;25:259-70
3. Cañete R, González ME, Almirall P, et al. Infección por Giardia y Giardiosis. Rev Panam Infectol 2004;6:39-46
4. Upcroft P, Upcroft J. Drug targets and mechanisms of resistance in the anaerobic protozoa. Clin Microbiol Rev 2001;14:150-64
5. Aparicio P, Rodríguez E, Gárate T, et al. Terapéutica antiparasitaria. Enferm Infecc Microbiol Clin 2003;21:579-94
6. Harris JC, Plummer S, Lloyd D. Antigiardial drugs. Appl Microbiol Biotechnol 2001;57:614-9
7. Wright JM, Dunn LA, Upcroft P, et al. Efficacy of antigiardial drugs. Expert Opin Drug Saf 2003;2:529-41
8. Escobedo AA, Núñez FA, Moreira I, et al. Comparison of chloroquine, albendazole and tinidazole in the treatment of children with giardiasis. Ann Trop Med Parasitol 2003;97:367-71
9. Rodríguez-García R, Rodríguez-Guzmán LM, Cruz del Castillo AH. Effectiveness and safety of mebendazole compared to nitazoxanide in the treatment of Giardia lamblia in children. Rev Gastroenterol Mex 1999;64:122-6
10. White, AC Jr. Nitazoxanide: a new broad spectrum antiparasitic agent. Expert Rev Anti-infect Ther 2004;2:43-50
11. Fox LM, Saravolatz LD. Nitazoxanide: a new thiazolide anti-parasitic agent. Clin Infect Dis 2005;40:1173-80
12. Katiyar SK, Gordon VR, McLaughlin GL, et al. Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence. Antimicrob Agents Chemother 1994;38:2086-90
13. Edlind TD, Hang T, Chakraborty P. Activity of the antihelmintic benzimidazoles against Giardia lamblia in vitro. J Infect Dis 1990;162:1408-11
14. Chávez B, Cedillo-Rivera R, Martínez-Palomo A. Giardia lamblia: ultrastructural study of the in-vitro effect of benzimidazoles. J Parasitol 1992;39:510-5
15. Cedillo-Rivera R, Muñoz O. In vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents. J Med Microbiol 1992;37:221-4
16. Morgan UM, Reynoldson JA, Thompson RC. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro. Antimicrob Agents Chemother 1993;37:328-31
17. Katelaris PH, Naeem A, Farthing MJ. Activity of metronidazole, azithromycin and three benzimidazoles on Giardia lamblia growth and attachment to a human intestinal cell line. Aliment Pharmacol Therapeut 1994;8:187-92
18. Gascon J, Moreno A, Valls ME, et al. Failure of mebendazole treatment in Giardia lamblia infection. Trans R Soc Trop Med Hyg 1989;83:647
19. di Martino L, Nocerino A, Pettoello M. Mebendazole in giardial infections: confirmation of the failure of this treatment. Trans R Soc Trop Med Hyg 1991;85:557-8
20. Bulut BU, Gulnar SB, Aysev D. Alternative treatment protocols in giardiasis: a pilot study. Scand J Infect Dis 1996;28:493-5
21. Al-Waili NS, Al-Waili BH, Saloom KY. Therapeutic use of mebendazole in giardial infections. Trans R Soc Trop Med Hyg 1988;82:438
22. Al-Waili NS, Hasan NU. Mebendazole in giardial infections: a comparative study with metronidazole. J Infect Dis 1992;165:1170-1
23. Sadjjadi SM, Alborzi AW, Mostovfi H. Comparative clinical trial of mebendazole and metronidazole in Giardiasis of children. J Trop Pediatr 2001;47:176-8
24. Bethony J, Brooker S, Albonico M, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 2006;367:1521-32
25. García LS, Bruckner DA. Macroscopic and microscopic examination of fecal specimens. In: Diagnostic medical parasitology. Washington, DC: American Society for Microbiology, 1993, pp. 501-40
26. Armitage P, Berry G. Statistical methods in medical research, 2nd edn. Oxford: Blackwell Scientific, 1987
27. Pengsaa K, Limkittikul K, Pojjaroen-anant C, et al. Single-dose therapy for Giardia in school-age children. Southeast Asian J Trop Med Public Health 2002;33:711-7
28. Zani LC, Favre TC, Pieri OS, et al. Impact of antihelminthic treatment on infection by Ascaris lumbricoides, Trichuris trichiura and hookworms in Covas, a rural community of Pernambuco, Brazil. Rev Inst Med Trop Sao Paulo 2004;46:63-71
29. Escobedo AA, Cañete R, Gonzalez ME, et al. A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis. Ann Trop Med Parasitol 2003;97:499-504
30. Cañete R, Escobedo AA, Gonzalez ME, et al. Randomized clinical study of five days therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children. World J Gastroenterol 2006;12(37): in press
31. Pengsaa K, Sirivichayakul C, Pojjaroen-anant C, et al. Albendazole treatment for Giardia intestinalis infections in school children. Southeast Asian J Trop Med Public Health 1999;30:78-83
32. Nigam P, Kapoor KK, Kumar A, et al. Clinical profile of giardiasis and comparison of its therapeutic response to metronidazole and tinidazole. J Assoc Physicians India 1991;39:613-5
33. Mendoza D, Nunez FA, Escobedo AA, et al. Usefulness of 2 coproparasitological methods and their utilization in an antigiardiasis therapeutic trial [in Spanish]. Rev Cubana Med Trop 2003;55:174-8
34. Apte W, Packard RS. Tinidazole in the treatment of trichomoniasis, giardiasis and amoebiasis. Report of a multicentre study. Drugs 1978;15(Suppl 1):43-8
35. Gazder AJ, Banerjee M. Single dose therapy of giardiasis with tinidazole and metronidazole. Drugs 1978;15(Suppl 1):30-2