Toxicological evaluations of methanolic extract of moringa oleifera leaves in liver and kidney of male wistar rats

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 24, Issue 4, 2013, Pages 307-312

  Oyagbemi, Ademola A ^a   Omobowale, Temitayo O ^a   Azeez, Ibraheem O ^a   Abiola, John O ^a   Adedokun, Rahamon A M ^a   Nottidge, Helen O ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Kidney; Liver; Moringa oleifera; Toxicity assessment

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CORN OIL; CREATININE; GLOBULIN; METHANOL; MORINGA OLEIFERA EXTRACT; PROTEIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BEVERAGE; BODY WEIGHT; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; FOOD INTAKE; LIVER TOXICITY; LONG TERM EXPOSURE; MALE; MORINGA OLEIFERA; NEPHROTOXICITY; NONHUMAN; PLANT LEAF; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RAT; TOXICITY TESTING; UREA BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; WEIGHT GAIN; WISTAR RAT;

ANIMALS; KIDNEY; KIDNEY FUNCTION TESTS; LIVER; LIVER FUNCTION TESTS; MALE; METHANOL; MORINGA OLEIFERA; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; TOXICITY TESTS, SUBCHRONIC;

EID: 84898641669     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/jbcpp-2012-0061     Document Type: Article

References (44)

1. D'Souza J, Kulkarni AR. Comparative studies on nutritive values of tender foliage of seedlings and mature plants of Moringa oleifera Lam. J Economic Taxon Botany 1993;17:479-85.
2. Viera GH, Mourao JA, Angelo AM, Costa RA, Vieira RH. Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria. Rev Inst Med Trop Sao Paulo 2010;52:129-32.
3. Promkum C, Kupradinun P, Tuntipopipat S, Butryee C. Nutritive evaluation and effect of Moringa oleifera pod on clastogenic potential in the mouse. Asian Pac J Cancer Prev 2010;11:627-32.
4. Oluduro OA, Aderiye BI, Connolly JD, Akintayo ET, Famurewa O. Characterization and antimicrobial activity of 4-(β-D-glucopyranosyl- 1→4-α-L-rhamnopyranosyloxy)-benzyl thiocarboxamide; a novel bioactive compound from Moringa oleifera seed extract. Folia Microbiol (Praha) 2010;55:422-6.
5. Debnath S, Biswas D, Ray K, Guha D. Moringa oleifera induced potentiation of serotonin release by 5-HT(3) receptors in experimental ulcer model. Phytomedicine 2011;18:91-5.
6. Ogunsina BS, Radha C, Indrani D. Quality characteristics of bread and cookies enriched with debittered Moringa oleifera seed flour. Int J Food Sci Nutr 2011;62:185-94.
7. Ghasi S, Nwobodo E, Ofili JO. Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed Wistar rats. J Ethnopharmacol 2000;69:21-5.
8. Mehta LK, Balaraman R, Amin AH, Bafna PA, Gulati OD. Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. J Ethnopharmacol 2003;86:191-5.
9. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: A food plant with multiple medicinal uses. Phytother Res 2007;21:17-25.
10. Cheenpracha S, Park EJ, Yoshida WY, Barit C, Wall M, Pezzuto JM, et al. Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg Med Chem 2010;18:6598-602.
11. Chumark P, Khunawat P, Sanvarinda Y, Phornchirasilp S, Morales NP, Phivthong-Ngam L, et al. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. J Ethnopharmacol 2008;116:439-46.
12. Nambiar VS, Seshadri S. Bioavailability trials of β-carotene from fresh and dehydrated drumstick leaves (Moringa oleifera) in a rat model. Plant Foods Hum Nutr 2001;56:83-95.
13. Sreelatha S, Padma PR. Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity. Plant Foods Hum Nutr 2009;64:303-11.
14. Singh BN, Singh BR, Singh RL, Prakash D, Dhakarey R, Upadhyay G, et al. Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera. Food Chem Toxicol 2009;47:1109-16.
15. Atawodi SE, Atawodi JC, Idakwo GA, Pfundstein B, Haubner R, Wurtele G, et al. Evaluation of the polyphenol content and antioxidant properties of methanol extracts of the leaves, stem, and root barks of Moringa oleifera Lam. J Med Food 2010;13:710-6.
16. Valerio LG Jr, Arvidson KB, Busta E, Minnier BL, Kruhlak NL, Benz RD. Testing computational toxicology models with phytochemicals. Mol Nutr Food Res 2010;54:186-94.
17. Ambi AA, Abdurahman EM, Umar A, Katsayal UA, Sule MI, Pateh UU, et al. Toxicity evaluation of Moringa oleifera leaves. Int J Pharmaceut Res Innovat 2011;4:22-4.
18. Paul CW, Didia BC. The effect of methanolic extract of Moringa oleifera lam roots on the histology of kidney and liver of guinea pigs. Asian J Med Sci 2012;4:55-60.
19. Kavitha C, Ramesh M, Kumaran SS, Lakshmi SA. Toxicity of Moringa oleifera seed extract on some hematological and biochemical profiles in a freshwater fish, Cyprinus carpio. Exp Toxicol Pathol 2012;64:681-7.
20. Awodele O, Oreagba IA, Odoma S, da Silva JA, Osunkalu VO. Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae). J Ethnopharmacol 2012;139:330-6.
21. Asare GA, Gyan B, Bugyei K, Adjei S, Mahama R, Addo P, et al. Toxicity potentials of the nutraceutical Moringa oleifera at suprasupplementation levels. J Ethnopharmacol 2012;139:265-72.
22. Rolim LA, Macedo MF, Sisenando HA, Napoleao TH, Felzenszwalb I, Aiub CA, et al. Genotoxicity evaluation of Moringa oleifera seed extract and lectin. J Food Sci 2011;76:T53-8.
23. Chivapat S, Sincharoenpokai P, Saktiyasuthorn N, Shuaprom A, Thongsrirak P, Sakpetch A, et al. Acute and chronic toxicity of Moringa oleifera Linn leaves extracts. Thai J Vet Med 2011;41:417-24.
24. Adedapo AA, Mogbojuri OM, Emikpe BO. Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats. J Med Plants Res 2009;8:586-91.
25. Public Health Service (PHS). Public health service policy on humane care and the use of laboratory animals. Washington, DC: US Department of Health and Human services, 1996:99-158.
26. Gornall AG, Bardawill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949;177:751-66.
27. Steven CK. Alanine and aspartate aminotransferase, principle and usage. In: James JT, Jenifer R, editors. Liver function. Clinical chemistry theory, analysis and correlation, 3rd ed. London: M. Mosby, 1996:504-27.
28. Gustafsson JE. Improved specificity of serum albumin determination and estimation of acute phase reactant by the use of bromocresol green reaction. Clin Chem 1976;22:616-22.
29. Marsh WH, Fingerhut B, Miller H. Automated and manual direct methods for the determination of blood urea. Clin Chem 1965;11:624-7.
30. Biod T, Sirota B. In: Watson A, editor. Practical clinical biochemistry. New Delhi: Prentice-Hall of India Private Ltd., 1948:142-5.
31. Fraunfelder FW. Ocular side effects from herbal medicines and nutritional supplements. Am J Ophthalmol 2004;138:639-47.
32. Sudha P, Asdaq SM, Dhamingi SS, Chandrakala GK. Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in animals. Indian J Physiol Pharmacol 2010;54:133-40.
33. Manaheji H, Jafari S, Zaringhalam J, Rezazadeh S, Taghizadfarid R. Analgesic effects of methanolic extracts of the leaf or root of Moringa oleifera on complete Freund's adjuvant-induced arthritis in rats. Zhong Xi Yi Jie He Xue Bao 2011;9:216-22.
34. Gupta A, Gautam MK, Singh RK, Kumar MV, Rao CV, Goel RK, et al. Immunomodulatory effect of Moringa oleifera Lam. extract on cyclophosphamide induced toxicity in mice. Indian J Exp Biol 2010;48:1157-60.
35. Mahajan SG, Mehta AA. Immunosuppressive activity of ethanolic extract of seeds of Moringa oleifera Lam. in experimental immune inflammation. J Ethnopharmacol 2010;130:183-6.
36. Ashok Kumar BS, Lakshman K, Arun Kumar PA, Viswantha GL, Veerapur VP, Thippeswamy BS, et al. Hepatoprotective activity of methanol extract of Amaranthus caudatus Linn against paracetamol-induced hepatic injury in rats. Zhong Xi Yi Jie He Xue Bao 2011;9:194-200.
37. Soumendra D, Abhijit B, Shyamaprasad C. Ameliorative effect of Livina, a polyherbal preparation on Diclofenacinduced liver injury: A comparison with Silymarin. J Pharm Res 2010;3:2794-8.
38. Nkosi CZ, Opoku AR, Terblanche SE. Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low protein feed rats. Phytother Res 2005;19:341-5.
39. Sharma MK, Kumar M, Kumar A. Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol 2002;40:1079-82.
40. Tessari P, Sofia A, Saffioti S, Vettore M, Verzola D, Millioni R, et al. Effects of chronic metabolic acidosis on splanchnic protein turnover and oxygen consumption in human beings. Gastroenterology 2010;138:1557-65.
41. Workeneh BT, Mitch WE. Review of muscle wasting associated with chronic kidney disease. Am J Clin Nutr 2010;91:1128S-32S.
42. Mayne PD. The kidneys and renal calculi. In: Clinical chemistry in diagnosis and treatment, 6th ed. London: Edward Arnold Publications, 1994:2-24.
43. Ali BH, Ben Ismail TH, Basheer AA. Sex related differences in the susceptibility of rat to gentamicin nephrotoxicity: influence of gonadectomy and hormonal replacement therapy. Ind J Pharmacol 2001;33:369-73.
44. Flaoyen A, Hove K, Wilkins AL. Tolerance to nephrotoxic component of Narthecium ossifragum in sheep: The effects of repeated oral doses of plant extracts. Vet Res Commun 2001;25:127-36.