Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels

Journal of Ethnopharmacology

Volumn 139, Issue 1, 2012, Pages 265-272

  Asare, George Awuku ^a   Gyan, Ben ^b   Bugyei, Kwasi ^a   Adjei, Samuel ^b   Mahama, Razak ^a   Addo, Phyllis ^b   Otu Nyarko, Lydia ^a   Wiredu, Edwin Kwame ^a   Nyarko, Alexander ^b  

^a UNIVERSITY OF GHANA   (Ghana)

^b University of Ghana   (Ghana)

Author keywords

Acute toxicity; Cytotoxicity; Genotoxicity; Moringa oleifera

Indexed keywords

HEMOGLOBIN; LACTATE DEHYDROGENASE; MORINGA OLEIFERA EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW BIOPSY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SAFETY; GENOTOXICITY; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; IN VIVO STUDY; LD 50; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MORINGA OLEIFERA; NONHUMAN; RAT; RISK ASSESSMENT; TREATMENT OUTCOME;

ANIMALS; BONE MARROW; CHLORIDES; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOLOGIC TESTS; L-LACTATE DEHYDROGENASE; LEUKOCYTES, MONONUCLEAR; MALE; MICRONUCLEUS TESTS; MORINGA OLEIFERA; MUTAGENS; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN; SODIUM; TOXICITY TESTS, ACUTE; UREA;

MORINGA; MORINGA OLEIFERA; MORINGACEAE; RATTUS;

EID: 83555174660     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.11.009     Document Type: Article

References (43)

1. A.A. Adedapo, M.O. Mogbojuri, and B.O. Emikpe Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats Journal of Medicinal Plants Research 3 2009 586 591
2. R. Arora, D. Gupta, R. Chawla, R. Sagar, A. Sharma, R. Kumar, J. Prasad, S. Singh, N. Samanta, and R.K. Sharma Radioprotection by plant products: present status and future prospects Phytotherapy Research 19 2005 1 22 (Pubitemid 40444988)
3. K. Aruna, and V.M. Sivaramakrishnan Plant products as protective agents against cancer Indian Journal of Experimental Biology 28 1990 1008 1011
4. S.E. Atawodi, J.C. Atawodi, G.A. Idakwo, B. Pfundstein, R. Haubner, G. Wurtele, H. Bartsch, and R.W. Owen Evaluation of the polyphenol content and antioxidant properties of methanol extracts of the leaves, stem, and root barks of Moringa oleifera Lam Journal of Medicinal Food 13 2010 710 716
5. A. Cáceres, O. Cabrera, O. Morales, P. Mollinedo, and P. Mendia Pharmacological properties of Moringa oleifera. 1. Preliminary screening for antimicrobial activity Journal of Ethnopharmacology 33 1991 213 216
6. A. Caceres, A. Saravia, S. Rizzo, L. Zabala, E.D. Leon, and F. Nave Pharmacologic properties of Moringa oleifera. 2. Screening for antispasmodic, anti-inflammatory and diuretic activity Journal of Ethnopharmacology 36 1992 233 237
7. K.B. Chinmoy Possible role of Moringa oleifera Lam. root in epithelial ovarian cancer Medscape General Medicine 9 2007 26
8. S.Y. Dangi, C.I. Jolly, and S. Narayanan Antihypertensive activity of the total alkaloids from the leaves of Moringa oleifera Pharmaceutical Biology 40 2002 144 148 (Pubitemid 34765393)
9. B.K. Das, and S.C. Mukherjee Asian fisheries science Journal of Asian Fisheries Society 13 2000 225 233
10. D. Diallo, B. Hveem, M.A. Mahmoud, G. Berge, B.S. Paulsen, and A. Maiga An ethnobotanical survey of herbal drugs of Gourma district, Mali Pharmaceutical Biology 37 1999 80 91 (Pubitemid 29381016)
11. D. Diallo, A. Marston, C. Terreaux, Y. Toure, B.S. Paulsen, and K. Hostettmann Screening of Malian medicinal plants for antifungal, larvicidal, molluscidal, antioxidant and radical scavenging activities Phytotherapy Research 15 2001 401 406 (Pubitemid 32762387)
12. H.O. Edeoga, D.E. Okwu, and B.O. Mbaebie Phytochemical constituents of some Nigerian medicinal plants African Journal of Biotechnology 4 2005 685 688 (Pubitemid 41032246)
13. S. Faizi, B.S. Siddiqui, R. Saleem, K. Aftab, F. Shaheen, and A.H. Gilani Hypotensive constituents from the pods of Moringa oleifera Planta Medica 64 1998 225 228 (Pubitemid 28184009)
14. L.J. Fuglie Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure Journal of Natural Products 57 1999 1256 1261
15. L.J. Fuglie The Miracle Tree. Moringa oleifera: Natural Nutrition for the Tropics 1999 CWS/Dakar p. 68
16. S. Ghasi, E. Nwobodo, and J.O. Ofili Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats Journal of Ethnopharmacology 69 2000 21 25 (Pubitemid 29505288)
17. Gias, U.M.; 1998. Standardization of Herbal Preparation. The Independent, Monday, 30 March, p. 13.
18. G. Haslam, D. Wyatt, and P.A. Kitos Estimating the number of viable animal cells in multi-well cultures based on their lactate dehydrogenase activities Cytotechnology 32 2000 63 75 (Pubitemid 30065116)
19. Health Effect Test Guidelines (HETG), 1998. Mammalian Erythrocyte Micronucleus Test. OPPTS 870, 5395 U.S. Office of Prevention, Pesticides and Toxic Substances Environmental Protection Agency (7101). Available from: www.epa.gov/epahome/research.htm (accessed 12.12.10).
20. D. Helbig, A. Wagner, M. Glei, S. Basu, R. Schubert, and G. Jahreis Blackcurrant seed press residue increases tocopherol concentrations in serum and stool whilst biomarkers in stool and urine indicate increased oxidative stress in human subjects British Journal of Nutrition 102 2009 554 562
21. R. Jabeen, M. Shahid, A. Jamil, and M. Ashraf Microscopic evaluation of the antimicrobial activity of seed extracts of Moringa oleifera Pakistani Journal of Botany 40 2008 1349 1358
22. S.A.A. Jahn Monitored water coagulation with Moringa oleifera seeds in village household Journal of Analytical Sciences 1 1986 40 41
23. R.V. Karadi, N.B. Gadge, K.R. Alagawadi, and R.V. Savadi Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats Journal of Ethnopharmacology 105 2006 306 311
24. K.R. Kirtikar, and K. Basu Indian Medicinal Plants 1984 Lalit Mohan Basu MB Allahabad, India pp. 677-681
25. U.K. Mazumder, M. Gupta, S. Chakrabarti, and D. Pal Evaluation of hematological and hepatorenal functions of methanolic extract of Moringa oleifera Lam. root treated mice Indian Journal of Experiment Biology 37 1999 612 614 (Pubitemid 29264453)
26. N. Mekonnen, P. Houghton, and J. Timbrell The toxicity of extracts of plant parts of Moringa stenopetala in HEPG2 cells in vitro Phytotherapy Research 19 2005 870 875 (Pubitemid 41665955)
27. T.G. Monera, R. Alan, C.C. Maponga, Z.B. Leslie, and J. Guglielmo Moringa oleifera leaf extracts inhibit 6β-hydroxylation of testosterone by CYP3A4 The Journal of Infection in Developing Countries 2 2008 379 383
28. J.F. Morton The horseradish tree, Moringa pterygosperma (Moringaceae) - a boon to arid lands? Economic Botany 45 1991 318 333
29. D. Nath, N. Sethi, R.K. Singh, and A.K. Jain Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats Journal of Ethnopharmacology 36 1992 147 154
30. F. Nikkon, A. Saud, M.H. Rahman, and M.E. Haque In vitro antimicrobial activity of the compound isolated from chloroform extract of Moringa oleifera Lam Pakistani Journal of Biological Sciences 6 2003 1888 1890
31. M.V.S. Pavathy, and A. Umamaheshwari Cytotoxic effect on Moringa oleifera leaf extracts on human multiple myloma cell lines Trends in Medical Research 2 2007 44 50
32. A.O. Prakash Ovarian response to aqueous extract of Moringa oleifera during early pregnancy in rats Fitoterapia 59 1988 89 96
33. C. Ramachandran, K.V. Peter, and P.K. Gopalakrishnan Drumstick (Moringa oleifera): a multipurpose Indian vegetable Economic Botany 34 1980 276 283
34. C.V. Rao, S.K. Ojha, and S. Mehrotra Analgesic effect of Moringa oleifera leaf extract on rats Proceedings of the Second World Congress on Biotechnological Developments of Herbal Medicine Lucknow, India 2003 p. 42
35. V.A. Rao, P.U. Devi, and R. Kamath In vivo radioprotective effect of Moringa oleifera leaves Indian Journal of Experimental Biology 39 2001 858 863 (Pubitemid 32824511)
36. S. Robinson, J.L. Delongeas, E. Donald, D. Dreher, and M. Festag European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development Regulatory Toxicology and Pharmacology 50 2008 345 352
37. K. Ruckmani, S. Kavimani, R. Anandan, and B. Jaykar Effect of Moringa oleifera Lam on paracetamol-induced hepatoxicity Indian Journal of Pharmaceutical Sciences 60 1998 33 35 (Pubitemid 28346194)
38. R.J. Shamberger The genotoxicity of selenium Mutagenesis Research 154 1985 29 48 (Pubitemid 15039543)
39. S. Siddiqui, and M.I. Khan Pharmacological Study of Moringa pterygosperma 1968 Central Laboratories. Pakistani Council of Science and Industrial Research pp. 268-272
40. S. Sreelatha, and P.R. Padma Antioxidant activity and total phenolic content of Moringa oleifera leaves of maturity Plant Foods and Human Nutrition 64 2009 303 311
41. S. Sreelatha, and P.R. Padma Protective mechanisms of Moringa oleifera against CCl(4)-induced oxidative stress in precision-cut liver slices Forschende Komplementärmedizin 17 2010 189 194
42. H.T. Wolterbeek, and A.J.G.M. van der Meer Optimization, application, and interpretation of lactate dehydrogenase measurements in microwell determination of cell number and toxicity Assay and Drug Development Technologies 3 2005 675 682 (Pubitemid 43256958)
43. S. Zaizuhana, J. Puteri, M.B. Noor, Y. Noral'ashikin, H. Muhammad, A.B. Rohana, and I. Zakiah The in vivo rodent micronucleus assay of Kacip Fatimah (Labisia pumila) extract Tropical Biomedicine 23 2006 214 219