-
1
-
-
79958717571
-
The global health burden of hepatitis c virus infection
-
Negro F, Alberti A. 2011. The global health burden of hepatitis C virus infection. Liver Int. 31(Suppl 2):1-3. http://dx.doi.org/10.1111/j.1478-3231. 2011.02537.x.
-
(2011)
Liver Int.
, vol.31
, Issue.SUPPL. 2
, pp. 1-3
-
-
Negro, F.1
Alberti, A.2
-
2
-
-
78751621217
-
Evolving epidemiology of hepatitis c virus
-
Lavanchy D. 2011. Evolving epidemiology of hepatitis C virus. Clin. Microbiol. Infect. 17:107-115. http://dx.doi.org/10.1111/j.1469-0691.2010.03432. x.
-
(2011)
Clin. Microbiol. Infect.
, vol.17
, pp. 107-115
-
-
Lavanchy, D.1
-
3
-
-
65449136656
-
Diagnosis, management, and treatment of hepatitis c: An update
-
Ghany MG, Strader DB, Thomas DL, Seeff LB. 2009. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 49:1335-1374. http://dx.doi.org/10.1002/hep.22759.
-
(2009)
Hepatology
, vol.49
, pp. 1335-1374
-
-
Ghany, M.G.1
Strader, D.B.2
Thomas, D.L.3
Seeff, L.B.4
-
4
-
-
84862330427
-
Update on the management and treatment of hepatitis c virus infection: Recommendations from the department of veterans affairs hepatitis c resource center program and the national hepatitis c program office
-
Yee HS, Chang MF, Pocha C, Lim J, Ross D, Morgan TR, Monto A. 2012. Update on the management and treatment of hepatitis C virus infection: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office. Am. J. Gastroenterol. 107:669-689. http://dx.doi.org/10.1038/ajg.2012.48.
-
(2012)
Am. J. Gastroenterol.
, vol.107
, pp. 669-689
-
-
Yee, H.S.1
Chang, M.F.2
Pocha, C.3
Lim, J.4
Ross, D.5
Morgan, T.R.6
Monto, A.7
-
5
-
-
61549118827
-
Nomenclature and numbering of the hepatitis c virus
-
Kuiken C, Simmonds P. 2009. Nomenclature and numbering of the hepatitis C virus. Methods Mol. Biol. 510:33-53. http://dx.doi.org/10.1007/978-1-59745-394- 3-4.
-
(2009)
Methods Mol. Biol.
, vol.510
, pp. 33-53
-
-
Kuiken, C.1
Simmonds, P.2
-
6
-
-
79958748633
-
A systematic review of hepatitis c virus epidemiology in europe, canada and israel
-
Cornberg M, Razavi HA, Alberti A, Bernasconi E, Buti M, Cooper C, Dalgard O, Dillion JF, Flisiak R, Forns X, Frankova S, Goldis A, Goulis I, Halota W, Hunyady B, Lagging M, Largen A, Makara M, Manolakopoulos S, Marcellin P, Marinho RT, Pol S, Poynard T, Puoti M, Sagalova O, Sibbel S, Simon K, Wallace C, Young K, Yurdaydin C, Zuckerman E, Negro F, Zeuzem S. 2011. A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel. Liver Int. 31(Suppl 2):30-60. http://dx.doi.org/10.1111/j.1478-3231.2011.02539.x.
-
(2011)
Liver Int.
, vol.31
, Issue.SUPPL. 2
, pp. 30-60
-
-
Cornberg, M.1
Razavi, H.A.2
Alberti, A.3
Bernasconi, E.4
Buti, M.5
Cooper, C.6
Dalgard, O.7
Dillion, J.F.8
Flisiak, R.9
Forns, X.10
Frankova, S.11
Goldis, A.12
Goulis, I.13
Halota, W.14
Hunyady, B.15
Lagging, M.16
Largen, A.17
Makara, M.18
Manolakopoulos, S.19
Marcellin, P.20
Marinho, R.T.21
Pol, S.22
Poynard, T.23
Puoti, M.24
Sagalova, O.25
Sibbel, S.26
Simon, K.27
Wallace, C.28
Young, K.29
Yurdaydin, C.30
Zuckerman, E.31
Negro, F.32
Zeuzem, S.33
more..
-
7
-
-
79960969718
-
Hepatitis c virus genotypes in clinical specimens tested at a national reference testing laboratory in the united states
-
Germer JJ, Mandrekar JN, Bendel JL, Mitchell PS, Yao JD. 2011. Hepatitis C virus genotypes in clinical specimens tested at a national reference testing laboratory in the United States. J. Clin. Microbiol. 49:3040-3043. http://dx.doi.org/10.1128/JCM.00457-11.
-
(2011)
J. Clin. Microbiol.
, vol.49
, pp. 3040-3043
-
-
Germer, J.J.1
Mandrekar, J.N.2
Bendel, J.L.3
Mitchell, P.S.4
Yao, J.D.5
-
8
-
-
79958698124
-
A systematic review of hepatitis c virus epidemiology in asia, australia and egypt
-
Sievert W, Altraif I, Razavi HA, Abdo A, Ahmed EA, Alomair A, Amarapurkar D, Chen CH, Dou X, El Khayat H, Elshazly M, Esmat G, Guan R, Han KH, Koike K, Largen A, McCaughan G, Mogawer S, Monis A, Nawaz A, Piratvisuth T, Sanai FM, Sharara AI, Sibbel S, Sood A, Suh DJ, Wallace C, Young K, Negro F. 2011. A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. Liver Int. 31(Suppl 2):61-80. http://dx.doi.org/10.1111/j.1478-3231.2011. 02540.x.
-
(2011)
Liver Int.
, vol.31
, Issue.SUPPL. 2
, pp. 61-80
-
-
Sievert, W.1
Altraif, I.2
Razavi, H.A.3
Abdo, A.4
Ahmed, E.A.5
Alomair, A.6
Amarapurkar, D.7
Chen, C.H.8
Dou, X.9
El Khayat, H.10
Elshazly, M.11
Esmat, G.12
Guan, R.13
Han, K.H.14
Koike, K.15
Largen, A.16
McCaughan, G.17
Mogawer, S.18
Monis, A.19
Nawaz, A.20
Piratvisuth, T.21
Sanai, F.M.22
Sharara, A.I.23
Sibbel, S.24
Sood, A.25
Suh, D.J.26
Wallace, C.27
Young, K.28
Negro, F.29
more..
-
9
-
-
77955509605
-
Risk factors, genotype 6 prevalence, and clinical characteristics of chronic hepatitis c in southeast asian americans
-
Nguyen NH, Vutien P, Trinh HN, Garcia RT, Nguyen LH, Nguyen HA, Nguyen KK, Nguyen MH. 2010. Risk factors, genotype 6 prevalence, and clinical characteristics of chronic hepatitis C in Southeast Asian Americans. Hepatol. Int. 4:523-529. http://dx.doi.org/10.1007/s12072-010-9181-7.
-
(2010)
Hepatol. Int.
, vol.4
, pp. 523-529
-
-
Nguyen, N.H.1
Vutien, P.2
Trinh, H.N.3
Garcia, R.T.4
Nguyen, L.H.5
Nguyen, H.A.6
Nguyen, K.K.7
Nguyen, M.H.8
-
10
-
-
79959981725
-
Systematic review: Epidemiology of hepatitis c genotype 6 and its management
-
Chao DT, Abe K, Nguyen MH. 2011. Systematic review: epidemiology of hepatitis C genotype 6 and its management. Aliment. Pharmacol. Ther. 34: 286-296. http://dx.doi.org/10.1111/j.1365-2036.2011.04714.x.
-
(2011)
Aliment. Pharmacol. Ther.
, vol.34
, pp. 286-296
-
-
Chao, D.T.1
Abe, K.2
Nguyen, M.H.3
-
11
-
-
51749084677
-
Chronic hepatitis c virus genotype 6 infection: Response to pegylated interferon and ribavirin
-
Fung J, Lai CL, Hung I, Young J, Cheng C, Wong D, Yuen MF. 2008. Chronic hepatitis C virus genotype 6 infection: response to pegylated interferon and ribavirin. J. Infect. Dis. 198:808-812. http://dx.doi.org/10.1086/591252.
-
(2008)
J. Infect. Dis.
, vol.198
, pp. 808-812
-
-
Fung, J.1
Lai, C.L.2
Hung, I.3
Young, J.4
Cheng, C.5
Wong, D.6
Yuen, M.F.7
-
12
-
-
84867402089
-
Once daily gs-7977 plus ribavirin inhcvgenotypes 1-3: The electron trial, poster 1113
-
Gane E, Stedman C, Hyland R, Sorensen R, Symonds W, Hindes R, Berrey M. 2012. Once daily GS-7977 plus ribavirin inHCVgenotypes 1-3: the ELECTRON Trial, poster 1113. 47th Annu. Meet. Eur. Assoc. Study Liver.
-
(2012)
47th Annu. Meet. Eur. Assoc. Study Liver.
-
-
Gane, E.1
Stedman, C.2
Hyland, R.3
Sorensen, R.4
Symonds, W.5
Hindes, R.6
Berrey, M.7
-
13
-
-
84898625200
-
Psi-7977 with peg/rbv elicits rapid declines in hcv rna in patients with hcv gt-4 and gt-6, abstr 50
-
Hassanein T, Nelson DR, Lawitz E, Dieterich D, Jacobson I, Baker C. 2011. PSI-7977 with PEG/RBV elicits rapid declines in HCV RNA in patients with HCV GT-4 and GT-6, abstr 50. HEPDart.
-
HEPDart
, pp. 2011
-
-
Hassanein, T.1
Nelson, D.R.2
Lawitz, E.3
Dieterich, D.4
Jacobson, I.5
Baker, C..6
-
14
-
-
84865050313
-
Hepatitis c virus in vietnam: High prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants
-
Dunford L, Carr MJ, Dean J, Waters A, Nguyen LT, Ta Thi TH, Thi LA, Do HD, Thi TT, Nguyen HT, Diem Do TT, Luu QP, Connell J, Coughlan S, Hall WW, Nguyen Thi LA. 2012. Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants. PLoS One 7:e41266. http://dx.doi.org/10.1371/journal.pone.0041266.
-
(2012)
PLoS One
, vol.7
-
-
Dunford, L.1
Carr, M.J.2
Dean, J.3
Waters, A.4
Nguyen, L.T.5
Ta Thi, T.H.6
Thi, L.A.7
Do, H.D.8
Thi, T.T.9
Nguyen, H.T.10
Diem Do, T.T.11
Luu, Q.P.12
Connell, J.13
Coughlan, S.14
Hall, W.W.15
Nguyen Thi, L.A.16
-
15
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis c: A randomised trial
-
Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK. 2001. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358:958-965. http://dx.doi.org/10.1016/S0140-6736(01)06102-5.
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
Rustgi, V.K.4
Shiffman, M.5
Reindollar, R.6
Goodman, Z.D.7
Koury, K.8
Ling, M.9
Albrecht, J.K.10
-
16
-
-
84887427894
-
Mk-5172, the 1st hcv protease inhibitor with potent activity against resistance mutations in vitro, abstr 39
-
Liverton N. 2010. MK-5172, the 1st HCV protease inhibitor with potent activity against resistance mutations in vitro, abstr 39. 45th Annu. Meet. Eur. Assoc. Study Liver.
-
(2010)
45th Annu. Meet. Eur. Assoc. Study Liver.
-
-
Liverton, N.1
-
17
-
-
79952296871
-
Recombinant hcv variants with ns5a from genotypes 1-7 have different sensitivities to an ns5a inhibitor but not interferon-Alpha
-
Scheel TK, Gottwein JM, Mikkelsen LS, Jensen TB, Bukh J. 2011. Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-Alpha. Gastroenterology 140:1032-1042. http://dx.doi.org/10.1053/j.gastro.2010.11.036.
-
(2011)
Gastroenterology
, vol.140
, pp. 1032-1042
-
-
Scheel, T.K.1
Gottwein, J.M.2
Mikkelsen, L.S.3
Jensen, T.B.4
Bukh, J.5
-
18
-
-
21844453965
-
The hepatitis c virus replicon system: From basic research to clinical application
-
Bartenschlager R. 2005. The hepatitis C virus replicon system: from basic research to clinical application. J. Hepatol. 43:210-216. http://dx.doi.org/10. 1016/j.jhep.2005.05.013.
-
(2005)
J. Hepatol.
, vol.43
, pp. 210-216
-
-
Bartenschlager, R.1
-
19
-
-
0037370622
-
Efficient replication of hepatitis c virus genotype 1a rnas in cell culture
-
Blight KJ, McKeating JA, Marcotrigiano J, Rice CM. 2003. Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture. J. Virol. 77:3181-3190. http://dx.doi.org/10.1128/JVI.77.5.3181-3190.2003.
-
(2003)
J. Virol.
, vol.77
, pp. 3181-3190
-
-
Blight, K.J.1
McKeating, J.A.2
Marcotrigiano, J.3
Rice, C.M.4
-
20
-
-
0345223476
-
Efficient replication of the genotype 2a hepatitis c virus subgenomic replicon
-
Kato T, Date T, Miyamoto M, Furusaka A, Tokushige K, Mizokami M, Wakita T. 2003. Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon. Gastroenterology 125:1808-1817. http://dx.doi.org/10.1053/j.gastro. 2003.09.023.
-
(2003)
Gastroenterology
, vol.125
, Issue.2003
, pp. 1808-1817
-
-
Kato, T.1
Date, T.2
Miyamoto, M.3
Furusaka, A.4
Tokushige, K.5
Mizokami, M.6
Wakita, T.7
-
21
-
-
0037369066
-
Viral and cellular determinants of hepatitis c virus rna replication in cell culture
-
Lohmann V, Hoffmann S, Herian U, Penin F, Bartenschlager R. 2003. Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J. Virol. 77:3007-3019. http://dx.doi.org/10.1128/JVI.77.5.3007-3019.2003.
-
(2003)
J. Virol.
, vol.77
, pp. 3007-3019
-
-
Lohmann, V.1
Hoffmann, S.2
Herian, U.3
Penin, F.4
Bartenschlager, R.5
-
22
-
-
0345188811
-
Replication of subgenomic hepatitis c virus rnas in a hepatoma cell line
-
Lohmann V, Korner F, Koch J, Herian U, Theilmann L, Bartenschlager R. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113. http://dx.doi.org/10.1126/science.285.5424.110.
-
(1999)
Science
, vol.285
, pp. 110-113
-
-
Lohmann, V.1
Korner, F.2
Koch, J.3
Herian, U.4
Theilmann, L.5
Bartenschlager, R.6
-
23
-
-
0034623816
-
Efficient initiation of hcv rna replication in cell culture
-
Blight KJ, Kolykhalov AA, Rice CM. 2000. Efficient initiation of HCV RNA replication in cell culture. Science 290:1972-1974. http://dx.doi.org/10.1126/ science.290.5498.1972.
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
24
-
-
84871270373
-
Development of robust hepatitis c virus genotype 4 subgenomic replicons
-
Peng B, Yu M, Xu S, Lee YJ, Tian Y, Yang H, Chan K, Mo H, McHutchison J, Delaney W, Cheng G. 2013. Development of robust hepatitis C virus genotype 4 subgenomic replicons. Gastroenterology 144: 59-61. http://dx.doi.org/10.1053/j. gastro.2012.09.033.
-
(2013)
Gastroenterology
, vol.144
, pp. 59-61
-
-
Peng, B.1
Yu, M.2
Xu, S.3
Lee, Y.J.4
Tian, Y.5
Yang, H.6
Chan, K.7
Mo, H.8
McHutchison, J.9
Delaney, W.10
Cheng, G.11
-
25
-
-
84871295307
-
Replication of hepatitis c virus genotype 3a in cultured cells
-
Saeed M, Gondeau C, Hmwe S, Yokokawa H, Date T, Suzuki T, Kato T, Maurel P, Wakita T. 2013. Replication of hepatitis C virus genotype 3a in cultured cells. Gastroenterology 144:56-58. http://dx.doi.org/10.1053/j.gastro.2012.09. 017.
-
(2013)
Gastroenterology
, vol.144
, pp. 56-58
-
-
Saeed, M.1
Gondeau, C.2
Hmwe, S.3
Yokokawa, H.4
Date, T.5
Suzuki, T.6
Kato, T.7
Maurel, P.8
Wakita, T.9
-
26
-
-
84866342634
-
Efficient replication of genotype 3a and 4a hepatitis c virus replicons in human hepatoma cells
-
Saeed M, Scheel TK, Gottwein JM, Marukian S, Dustin LB, Bukh J, Rice CM. 2012. Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells. Antimicrob. Agents Chemother. 56: 5365-5373. http://dx.doi.org/10.1128/AAC.01256-12.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5365-5373
-
-
Saeed, M.1
Scheel, T.K.2
Gottwein, J.M.3
Marukian, S.4
Dustin, L.B.5
Bukh, J.6
Rice, C.M.7
-
27
-
-
10644226734
-
Kissing-loop interaction in the 3= end of the hepatitis c virus genome essential for rna replication
-
Friebe P, Boudet J, Simorre JP, Bartenschlager R. 2005. Kissing-loop interaction in the 3= end of the hepatitis C virus genome essential for RNA replication. J. Virol. 79:380-392. http://dx.doi.org/10.1128/JVI.79.1.380-392. 2005.
-
(2005)
J. Virol.
, vol.79
, pp. 380-392
-
-
Friebe, P.1
Boudet, J.2
Simorre, J.P.3
Bartenschlager, R.4
-
28
-
-
77955368278
-
Novel hepatitis c virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a
-
Robinson M, Yang H, Sun SC, Peng B, Tian Y, Pagratis N, Greenstein AE, Delaney WE. 2010. Novel hepatitis C virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a. Antimicrob. Agents Chemother. 54:3099-3106. http://dx.doi.org/10.1128/AAC.00289-10.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 3099-3106
-
-
Robinson, M.1
Yang, H.2
Sun, S.C.3
Peng, B.4
Tian, Y.5
Pagratis, N.6
Greenstein, A.E.7
Delaney, W.E.8
-
29
-
-
79955532741
-
Selection of clinically relevant protease inhibitor-resistant viruses using the genotype 2a hepatitis c virus infection system
-
Cheng G, Chan K, Yang H, Corsa A, Pokrovskii M, Paulson M, Bahador G, Zhong W, Delaney W. 2011. Selection of clinically relevant protease inhibitor-resistant viruses using the genotype 2a hepatitis C virus infection system. Antimicrob. Agents Chemother. 55:2197-2205. http://dx.doi.org/10.1128/ AAC.01382-10.
-
(2011)
Antimicrob. Agents Chemother.
, Issue.55
, pp. 2197-2205
-
-
Cheng, G.1
Chan, K.2
Yang, H.3
Corsa, A.4
Pokrovskii, M.5
Paulson, M.6
Bahador, G.7
Zhong, W.8
Delaney, W.9
-
30
-
-
84896295869
-
Discovery of ledipasvir (gs-5885): A potent, once-daily oral ns5a inhibitor for the treatment of hepatitis c virus infection
-
11 December 2013
-
Link JO, Taylor JG, Xu L, Mitchell M, Guo H, Liu H, Kato D, Kirschberg T, Sun J, Squires N, Parrish J, Keller T, Yang ZY, Yang C, Matles M, Wang Y, Wang K, Cheng G, Tian Y, Mogalian E, Mondou E, Cornpropst M, Perry J, Desai MC. 11 December 2013. Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J. Med. Chem. http://dx.doi.org/10.1021/jm401499g.
-
J. Med. Chem
-
-
Link, J.O.1
Taylor, J.G.2
Xu, L.3
Mitchell, M.4
Guo, H.5
Liu, H.6
Kato, D.7
Kirschberg, T.8
Sun, J.9
Squires, N.10
Parrish, J.11
Keller, T.12
Yang, Z.Y.13
Yang, C.14
Matles, M.15
Wang, Y.16
Wang, K.17
Cheng, G.18
Tian, Y.19
Mogalian, E.20
Mondou, E.21
Cornpropst, M.22
Perry, J.23
Desai, M.C.24
more..
-
31
-
-
80051820156
-
Mechanistic characterization of gs-9190 (tegobuvir), a novel nonnucleoside inhibitor of hepatitis c virus ns5b polymerase
-
Shih IH, Vliegen I, Peng B, Yang H, Hebner C, Paeshuyse J, Purstinger G, Fenaux M, Tian Y, Mabery E, Qi X, Bahador G, Paulson M, Lehman LS, Bondy S, Tse W, Reiser H, Lee WA, Schmitz U, Neyts J, Zhong W. 2011. Mechanistic characterization of GS-9190 (tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase. Antimicrob. Agents Chemother. 55:4196-4203. http://dx.doi.org/10.1128/AAC.00307-11.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 4196-4203
-
-
Shih, I.H.1
Vliegen, I.2
Peng, B.3
Yang, H.4
Hebner, C.5
Paeshuyse, J.6
Purstinger, G.7
Fenaux, M.8
Tian, Y.9
Mabery, E.10
Qi, X.11
Bahador, G.12
Paulson, M.13
Lehman, L.S.14
Bondy, S.15
Tse, W.16
Reiser, H.17
Lee, W.A.18
Schmitz, U.19
Neyts, J.20
Zhong, W.21
more..
-
32
-
-
84862798044
-
Discovery of gs-9451: An acid inhibitor of the hepatitis c virus ns3/4a protease
-
Sheng XC, Appleby T, Butler T, Cai R, Chen X, Cho A, Clarke MO, Cottell J, Delaney WE, Doerffler E, Link J, Ji M, Pakdaman R, Pyun HJ, Wu Q, Xu J, Kim CU. 2012. Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease. Bioorg. Med. Chem. Lett. 22: 2629-2634. http://dx.doi.org/10. 1016/j.bmcl.2012.01.017.
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 2629-2634
-
-
Sheng, X.C.1
Appleby, T.2
Butler, T.3
Cai, R.4
Chen, X.5
Cho, A.6
Clarke, M.O.7
Cottell, J.8
Delaney, W.E.9
Doerffler, E.10
Link, J.11
Ji, M.12
Pakdaman, R.13
Pyun, H.J.14
Wu, Q.15
Xu, J.16
Kim, C.U.17
-
33
-
-
84872848108
-
Preclinical characterization of gs-9669, a thumb site ii inhibitor of the hepatitis c virus ns5b polymerase
-
Fenaux M, Eng Leavitt SSA, Lee YJ, Mabery EM, Tian Y, Byun D, Canales E, Clarke MO, Doerffler E, Lazerwith SE, Lew W, Liu Q, Mertzman M, Morganelli P, Xu L, Ye H, Zhang J, Matles M, Murray BP, Mwangi J, Hashash A, Krawczyk SH, Bidgood AM, Appleby TC, Watkins WJ. 2013. Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase. Antimicrob. Agents Chemother. 57:804-810. http://dx.doi.org/10.1128/AAC.02052- 12.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 804-810
-
-
Fenaux, M.1
Eng Leavitt, S.S.A.2
Lee, Y.J.3
Mabery, E.M.4
Tian, Y.5
Byun, D.6
Canales, E.7
Clarke, M.O.8
Doerffler, E.9
Lazerwith, S.E.10
Lew, W.11
Liu, Q.12
Mertzman, M.13
Morganelli, P.14
Xu, L.15
Ye, H.16
Zhang, J.17
Matles, M.18
Murray, B.P.19
Mwangi, J.20
Hashash, A.21
Krawczyk, S.H.22
Bidgood, A.M.23
Appleby, T.C.24
Watkins, W.J.25
more..
-
34
-
-
77957913871
-
Discovery of a beta-d-2=-deoxy-2=-Alpha-fluoro-2=-beta-c-methyluridine nucleotide prodrug (psi-7977) for the treatment of hepatitis c virus
-
Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, Niu C, Otto MJ, Furman PA. 2010. Discovery of a beta-D-2=-deoxy-2=-Alpha-fluoro- 2=-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J. Med. Chem. 53:7202-7218. http://dx.doi.org/10.1021/ jm100863x.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7202-7218
-
-
Sofia, M.J.1
Bao, D.2
Chang, W.3
Du, J.4
Nagarathnam, D.5
Rachakonda, S.6
Reddy, P.G.7
Ross, B.S.8
Wang, P.9
Zhang, H.R.10
Bansal, S.11
Espiritu, C.12
Keilman, M.13
Lam, A.M.14
Steuer, H.M.15
Niu, C.16
Otto, M.J.17
Furman, P.A.18
-
35
-
-
0034747214
-
Sequences in the 5= nontranslated region of hepatitis c virus required for rna replication
-
Friebe P, Lohmann V, Krieger N, Bartenschlager R. 2001. Sequences in the 5= nontranslated region of hepatitis C virus required for RNA replication. J. Virol. 75:12047-12057. http://dx.doi.org/10.1128/JVI.75.24.12047-12057.2001.
-
(2001)
J. Virol.
, vol.75
, pp. 12047-12057
-
-
Friebe, P.1
Lohmann, V.2
Krieger, N.3
Bartenschlager, R.4
-
36
-
-
13944253573
-
Regulating intracellular antiviral defense and permis-siveness to hepatitis c virus rna replication through a cellular rna helicase, rig-i
-
Sumpter R, Jr, Loo YM, Foy E, Li K, Yoneyama M, Fujita T, Lemon SM, Gale M, Jr. 2005. Regulating intracellular antiviral defense and permis-siveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J. Virol. 79:2689-2699. http://dx.doi.org/10.1128/JVI.79.5.2689-2699.2005.
-
(2005)
J. Virol.
, vol.79
, pp. 2689-2699
-
-
Sumpter Jr., R.1
Loo, Y.M.2
Foy, E.3
Li, K.4
Yoneyama, M.5
Fujita, T.6
Lemon, S.M.7
Gale Jr., M.8
-
37
-
-
84885334074
-
In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis c virus subgenomic replicons
-
Yu M, Corsa AC, Xu S, Peng B, Gong R, Lee YJ, Chan K, Mo H, Delaney W, IV, Cheng G. 2013. In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons. Antiviral Res. 100:439-445. http://dx.doi.org/10.1016/j.antiviral.2013.08.018.
-
(2013)
Antiviral Res
, vol.100
, pp. 439-445
-
-
Yu, M.1
Corsa, A.C.2
Xu, S.3
Peng, B.4
Gong, R.5
Lee, Y.J.6
Chan, K.7
Mo, H.8
Delaney IV, W.9
Cheng, G.10
-
38
-
-
0032518490
-
Hepatitis c virus ns3 rna helicase domain with a bound oligonucleotide: The crystal structure provides insights into the mode of unwinding
-
Kim JL, Morgenstern KA, Griffith JP, Dwyer MD, Thomson JA, Murcko MA, Lin C, Caron PR. 1998. Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure 6:89-100. http://dx.doi.org/10.1016/S0969-2126(98)00010-0.
-
(1998)
Structure
, vol.6
, pp. 89-100
-
-
Kim, J.L.1
Morgenstern, K.A.2
Griffith, J.P.3
Dwyer, M.D.4
Thomson, J.A.5
Murcko, M.A.6
Lin, C.7
Caron, P.R.8
-
39
-
-
0033571623
-
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis c virus bifunctional protease-helicase
-
Yao N, Reichert P, Taremi SS, Prosise WW, Weber PC. 1999. Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase. Structure 7:1353-1363. http://dx.doi.org/10.1016/S0969-2126(00)80025-8.
-
(1999)
Structure
, vol.7
, pp. 1353-1363
-
-
Yao, N.1
Reichert, P.2
Taremi, S.S.3
Prosise, W.W.4
Weber, P.C.5
-
40
-
-
54049154350
-
Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis c virus polymerase inhibitors
-
Herlihy KJ, Graham JP, Kumpf R, Patick AK, Duggal R, Shi ST. 2008. Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors. Antimicrob. Agents Chemother. 52:3523-3531. http://dx.doi.org/10.1128/AAC.00533-08.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 3523-3531
-
-
Herlihy, K.J.1
Graham, J.P.2
Kumpf, R.3
Patick, A.K.4
Duggal, R.5
Shi, S.T.6
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