Suppressing N-Myc downstream regulated gene 1 reactivates senescence signaling and inhibits tumor growth in hepatocellular carcinoma

Carcinogenesis

Volumn 35, Issue 4, 2014, Pages 915-922

  Lu, Wen Jing ^a   Chua, Mei Sze ^a   So, Samuel K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOGEN SYNTHASE KINASE 3BETA P53; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; SENESCENCE; TUMOR GROWTH; UPREGULATION;

BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL AGING; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; G1 PHASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84898626521     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt401     Document Type: Article

References (26)

1. El-Serag, H.B. (2011) Hepatocellular carcinoma. N. Engl. J. Med., 365, 1118-1127.
2. Altekruse, S.F. et al. (2009) Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J. Clin. Oncol., 27, 1485-1491.
3. Majno, P.E. et al. (2000) Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcome-oriented decision analysis. Hepatology, 31, 899-906.
4. Chen, X. et al. (2002) Gene expression patterns in human liver cancers. Mol. Biol. Cell, 13, 1929-1939.
5. Chua, M.S. et al. (2007) Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod. Pathol., 20, 76-83.
6. Cheng, J. et al. (2011) NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma. Cancer Lett., 310, 35-45.
7. Qu, X. et al. (2002) Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. Mol. Cell. Biochem., 229, 35-44.
8. Shaw, E. et al. (2002) Identification of a novel class in the alpha/beta hydrolase fold superfamily: the N-myc differentiation-related proteins. Proteins, 47, 163-168.
9. Melotte, V. et al. (2010) The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB J., 24, 4153-4166.
10. Salnikow, K. et al. (2002) The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol. Cell. Biol., 22, 1734-1741.
11. Sibold, S. et al. (2007) Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS Lett., 581, 989-994.
12. He, J. et al. (2003) Correlation of NDRG1 gene with liver tissue differentiation and hepatocarcinogenesis. Beijing Da Xue Xue Bao., 35, 471-475.
13. Northcott, P.A. et al. (2012) Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature, 488, 49-56.
14. Wang, D. et al. (2012) NDRG1/Cap43 overexpression in tumor tissues and serum from lung cancer patients. J. Cancer Res. Clin. Oncol., 138, 1813-1820.
15. Kawahara, A. et al. (2011) Nuclear expression of N-myc downstream regulated gene 1/Ca(2+)-associated protein 43 is closely correlated with tumor angiogenesis and poor survival in patients with gastric cancer. Exp. Ther. Med., 2, 471-479.
16. Ahn, J. et al. (2004) Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. J. Biochem. Mol. Biol., 37, 741-748.
17. Murray, J.T. et al. (2004) Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem. J., 384(Pt 3), 477-488.
18. Box, A.H. et al. (2004) Cell cycle kinase inhibitor expression and hypoxiainduced cell cycle arrest in human cancer cell lines. Carcinogenesis, 25, 2325-2335.
19. Kang, T.W. et al. (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature, 479, 547-551.
20. Hanahan, D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
21. Pineau, P. et al. (2008) Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure. Mutat. Res., 653, 6-13.
22. Lu, W.J. et al. (2011) Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin. Int. J. Cancer, 129, 1806-1814.
23. Lu, W.J. et al. (2011) Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differ., 18, 1046-1056.
24. Hussain, S.P. et al. (2007) TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene, 26, 2166-2176.
25. Kovacevic, Z. et al. (2011) The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms. Carcinogenesis, 32, 732-740.
26. Kobayashi, A. et al. (2011) Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J. Exp. Med., 208, 2641-2655.