Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Fan, Yue Mei ^a   Hernesniemi, Jussi ^a   Oksala, Niku ^a   Levula, Mari ^a   Raitoharju, Emma ^a   Collings, Auni ^a   Hutri Kähönen, Nina ^b   Juonala, Markus ^c   Marniemi, Jukka ^d   Lyytikäinen, Leo Pekka ^a   Seppälä, Ilkka ^a   Mennander, Ari ^a   Tarkka, Matti ^a   Kangas, Antti J ^e,f   Soininen, Pasi ^e,f   Salenius, Juha Pekka ^a   Klopp, Norman ^h   Illig, Thomas ^h   Laitinen, Tomi ^f   Ala Korpela, Mika ^e,f,g,i   Laaksonen, Reijo ^a   Viikari, Jorma ^j   Kähönen, Mika ^b   Raitakari, Olli T ^c   Lehtimäki, Terho ^a   more..

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e UNIVERSITY OF OULU   (Finland)

^f UNIVERSITY OF EASTERN FINLAND   (Finland)

^g OULU UNIVERSITY HOSPITAL   (Finland)

^h INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁱ UNIVERSITY OF BRISTOL   (United Kingdom)

^j UNIVERSITY OF TURKU   (Finland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UPSTREAM STIMULATORY FACTOR; USF1 PROTEIN, HUMAN;

ADULT; ALLELE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD; FEMALE; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; LIPID METABOLISM; MALE; PATHOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; RISK FACTOR; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; APOLIPOPROTEINS B; ATHEROSCLEROSIS; CHOLESTEROL, LDL; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; LIPID METABOLISM; MALE; PLAQUE, ATHEROSCLEROTIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; UPSTREAM STIMULATORY FACTORS;

EID: 84898621322     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04650     Document Type: Article

References (49)

1. Pajukanta, P. et al. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet 36, 371-6 (2004). (Pubitemid 38437259)
2. Sirito, M. et al.Members of the USF family of helix-loop-helix proteins bind DNA as homo-as well as heterodimers. Gene Expr 2, 231-40 (1992).
3. Plaisier, C. L. et al. A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia. PLoS Genet 5, e1000642 (2009).
4. Pajukanta, P. et al. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat Genet 18, 369-73 (1998). (Pubitemid 28158167)
5. Huertas-Vazquez, A. et al. Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1. Arterioscler Thromb Vasc Biol 25, 1985-91 (2005). (Pubitemid 41243473)
6. Holzapfel, C. et al. Genetic variants in the USF1 gene are associated with lowdensity lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Eur J Endocrinol 159, 407-16 (2008).
7. Meex, S. J. et al. Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians. Mol Genet Metab 94, 352-5 (2008).
8. Auro, K. et al. USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study. Diabetologia 51, 464-72 (2008).
9. Kristiansson, K. et al. Association analysis of allelic variants of USF1 in coronary atherosclerosis. Arterioscler Thromb Vasc Biol 28, 983-9 (2008). (Pubitemid 351544117)
10. Collings, A. et al. Allelic variants of upstream transcription factor 1 associate with carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns study. Circ J 72, 1158-64 (2008). (Pubitemid 351957085)
11. Komulainen, K. et al. Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies. PLoS Genet 2, e69 (2006).
12. Wu, S. et al.Upstream transcription factor 1 influences plasma lipid andmetabolic traits in mice. Hum Mol Genet 19, 597-608 (2010).
13. Lee, J. C. et al. USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease. Arterioscler Thromb Vasc Biol 27, 2222-7 (2007). (Pubitemid 350287253)
14. Coon, H. et al. Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides. Hum Genet 117, 444-51 (2005). (Pubitemid 41236365)
15. Blacher, J. et al. Carotid arterial stiffness as a predictor of cardiovascular and allcause mortality in end-stage renal disease. Hypertension 32, 570-4 (1998). (Pubitemid 28429151)
16. Bonetti, P. O., Lerman, L. O. & Lerman, A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23, 168-75 (2003). (Pubitemid 36231924)
17. Lorenz, M. W., von Kegler, S., Steinmetz, H., Markus, H. S. & Sitzer, M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke 37, 87-92 (2006). (Pubitemid 43732053)
18. O'Leary, D. H. et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340, 14-22 (1999). (Pubitemid 29024679)
19. Schroeder, S. et al. Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging. Am Heart J 138, 731-9 (1999). (Pubitemid 29471049)
20. Simons, P. C., Algra, A., Bots, M. L., Grobbee, D. E. & van der Graaf, Y. Common carotid intima-media thickness and arterial stiffness: indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of ARTerial disease). Circulation 100, 951-7 (1999). (Pubitemid 29407176)
21. Oksala, N. et al. ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries-Tampere vascular study. Ann Med 41, 279-90 (2009).
22. Raitakari, O. T. et al. Cohort profile: the cardiovascular risk in Young Finns Study. Int J Epidemiol 37, 1220-6 (2008).
23. Raitoharju, E. et al.miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis 219, 211-7 (2011).
24. Naukkarinen, J. et al. USF1 and dyslipidemias: converging evidence for a functional intronic variant. Hum Mol Genet 14, 2595-605 (2005). (Pubitemid 41236071)
25. Naukkarinen, J. et al. Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias. Circ Cardiovasc Genet 2, 522-9 (2009).
26. Ng, M. C. et al. The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. Diabetologia 48, 2018-24 (2005). (Pubitemid 41416912)
27. Hoffstedt, J., Rydén, M.,Wahrenberg, H., van Harmelen, V. & Arner, P. Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis. J Clin Endocrinol Metab 90, 5356-60 (2005). (Pubitemid 41262301)
28. Laurila, P. P. et al. Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis. Arterioscler Thromb Vasc Biol 30, 346-52 (2010).
29. Zeggini, E. et al. Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes 55, 2541-8 (2006). (Pubitemid 44871154)
30. Silander, K. et al. Gender differences in genetic risk profiles for cardiovascular disease. PLoS One 3, e3615 (2008).
31. Damas, J. K. et al. Myocardial expression of CC-and CXC-chemokines and their receptors in human end-stage heart failure. Cardiovasc Res 47, 778-87 (2000).
32. Misra, P. et al. Quantitation of CXCR4 expression in myocardial infarction using 99mTc-labeled SDF-1alpha. J Nucl Med 49, 963-9 (2008). (Pubitemid 351793437)
33. Chonchol, M. & Nielson, C. Hemoglobin levels and coronary artery disease. Am Heart J 155, 494-8 (2008).
34. Go,A. S. et al.Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study. Circulation 113, 2713-23 (2006).
35. Friedewald,W. T., Levy, R. I. & Fredrickson, D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499-502 (1972).
36. Raiko, J. R. et al. Follow-ups of the Cardiovascular Risk in Young Finns Study in 2001 and 2007: levels and 6-year changes in risk factors. J Intern Med 267, 370-84 (2010).
37. Raitakari, O. T. et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 290, 2277-83 (2003). (Pubitemid 37430560)
38. Juonala, M. et al. Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study. Circulation 110, 2918-23 (2004). (Pubitemid 39473618)
39. Juonala, M. et al. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 112, 1486-93 (2005). (Pubitemid 41291774)
40. Soininen, P. et al. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst 134, 1781-5 (2009).
41. Stanciáková, A. et al. Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men. Diabetes 60, 1608-1616 (2011).
42. Chambers, J. C. et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 43, 1131-8 (2011).
43. International Consortium for Blood Pressure Genome-Wide Association Studies et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478, 103-9 (2011).
44. Tukiainen, T. et al. Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci. Hum Mol Genet 21, 1444-55 (2012).
45. Levula, M. et al. ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study. Ann Med 41, 497-507 (2009).
46. Oksala, N. et al. Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study. Ann Med 42, 360-70 (2010).
47. Niinisalo, P. et al. Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study. Ann Med 42, 55-63 (2010).
48. Stary, H. C. et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92, 1355-74 (1995).
49. Stephens, M. & Donnelly, P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73, 1162-9 (2003). (Pubitemid 37414228)