Production of pigs expressing a transgene under the control of a tetracycline-inducible system

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Jin, Yong Xun ^a   Jeon, Yubyeol ^a   Lee, Sung Hyun ^a   Kwon, Mo Sun ^b   Kim, Teoan ^b   Cui, Xiang Shun ^a   Hyun, Sang Hwan ^a   Kim, Nam Hyung ^a  

^a Chungbuk National University   (South Korea)

^b Catholic University of Daegu   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; ENHANCED GREEN FLUORESCENT PROTEIN; MITOCHONDRIAL DNA; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; CELL COUNT; CELL NUCLEUS TRANSPLANTATION; CLONING; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FIBROBLAST; GENE EXPRESSION SYSTEM; GENE INSERTION; GENE TARGETING; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; REPORTER GENE; SOMATIC CELL; TET GENE; TRANSGENE; TRANSGENIC PIG;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELLS, CULTURED; CLONING, MOLECULAR; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; GENE EXPRESSION; GENES, REPORTER; GENETIC ENGINEERING; GREEN FLUORESCENT PROTEINS; NUCLEAR TRANSFER TECHNIQUES; ORGANISMS, GENETICALLY MODIFIED; SUS SCROFA; TETRACYCLINE; TRANSCRIPTIONAL ACTIVATION; TRANSGENES;

EID: 84898619066     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086146     Document Type: Article

References (34)

1. Hemann M, Shen HG, Beach NM, Meng XJ, Halbur PG, et al. (2012) Expression of human CD46 has no effect on porcine circovirus type 2 infection and shedding in the experimental pig model. Vet Res Commun 36: 187-193.
2. Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, et al. (2003) Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 299: 411-414.
3. Watanabe M, Kurome M, Matsunari H, Nakano K, Umeyema K, et al. (2012) The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer. Transgenic Res 21: 605-618.
4. Yeom HJ, Koo OJ, Yang J, Cho B, Hwang JI, et al. (2012) Generation and characterization of human heme oxygenase-1 transgenic pigs. PLoS One 7: e46646.
5. Giraldo AM, Ball S, Bondioli KR (2012) Production of transgenic and knockout pigs by somatic cell nuclear transfer. Methods Mol Biol 885: 105-123.
6. Furth PA, St Onge L, Boger H, Gruss P, Gossen M, et al. (1994) Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A 91: 9302-9306.
7. Gil GC, Velander WH, Van Cott KE (2008) Analysis of the N-glycans of recombinant human Factor IX purified from transgenic pig milk. Glycobiology 18: 526-539. (Pubitemid 351865833)
8. Katter K, Geurts AM, Hoffmann O, Mates L, Landa V, et al. (2013) Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J 27: 930-941.
9. Tong J, Lillico SG, Bi MJ, Qing T, Liu XF, et al. (2011) Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice. Transgenic Res 20: 933-938.
10. Cho YS, Lee SY, Kim YK, Kim DS, Nam YK (2011) Functional ability of cytoskeletal beta-actin regulator to drive constitutive and ubiquitous expression of a fluorescent reporter throughout the life cycle of transgenic marine medaka Oryzias dancena. Transgenic Res 20: 1333-1355.
11. Weidenfeld-Baranboim K, Hasin T, Darlyuk I, Heinrich R, Elhanani O, et al. (2009) The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3. Nucleic Acids Res 37: 2194-2203.
12. Lee SH, Gupta MK, Han DW, Han SY, Uhm SJ, et al. (2007) Development of transgenic chickens expressing human parathormone under the control of a ubiquitous promoter by using a retrovirus vector system. Poult Sci 86: 2221-2227. (Pubitemid 47580876)
13. Orian JM, Lee CS, Weiss LM, Brandon MR (1989) The expression of a metallothionein-ovine growth hormone fusion gene in transgenic mice does not impair fertility but results in pathological lesions in the liver. Endocrinology 124: 455-463. (Pubitemid 19033681)
14. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, et al. (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268: 1766-1769.
15. Takiguchi M, James C, Josefsson EC, Carmichael CL, Premsrirut PK, et al. (2010) Transgenic, inducible RNAi in megakaryocytes and platelets in mice. J Thromb Haemost 8: 2751-2756.
16. Bockamp E, Sprengel R, Eshkind L, Lehmann T, Braun JM, et al. (2008) Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration. Regen Med 3: 217-235. (Pubitemid 351546461)
17. Jiang BC, Yu DB, Wang LJ, Dong FL, Kaleri HA, et al. (2012) Doxycyclineregulated growth hormone gene expression system for swine. Genet Mol Res 11: 2946-2957.
18. Hong SG, Kim MK, Jang G, Oh HJ, Park JE, et al. (2009) Generation of red fluorescent protein transgenic dogs. Genesis 47: 314-322.
19. Koo BC, Kwon MS, Lee H, Kim M, Kim D, et al. (2010) Tetracyclinedependent expression of the human erythropoietin gene in transgenic chickens. Transgenic Res 19: 437-447.
20. Roth S, Franken P, van Veelen W, Blonden L, Raghoebir L, et al. (2009) Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology. Genesis 47: 7-13.
21. Kim MJ, Oh HJ, Park JE, Kim GA, Hong SG, et al. (2011) Generation of transgenic dogs that conditionally express green fluorescent protein. Genesis 49: 472-478.
22. Kues WA, Schwinzer R, Wirth D, Verhoeyen E, Lemme E, et al. (2006) Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double-transgenic pigs. FASEB J 20: 1200-1202.
23. Klymiuk N, Bocker W, Schonitzer V, Bahr A, Radic T, et al. (2012) First inducible transgene expression in porcine large animal models. FASEB J 26: 1086-1099.
24. Kwak SS, Cheong SA, Jeon Y, Hyun SH (2012) Porcine granulocytemacrophage colony-stimulating factor improves the in vitro development of cloned porcine embryos. J Vet Med Sci 74: 1095-1102.
25. Choi BR, Koo BC, Ahn KS, Kwon MS, Kim JH, et al. (2006) Tetracyclineinducible gene expression in nuclear transfer embryos derived from porcine fetal fibroblasts transformed with retrovirus vectors. Mol Reprod Dev 73: 1221-1229. (Pubitemid 44325231)
26. Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, et al. (2000) Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A 97: 7963-7968. (Pubitemid 30460756)
27. Lamartina S, Silvi L, Roscilli G, Casimiro D, Simon AJ, et al. (2003) Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates. Mol Ther 7: 271-280. (Pubitemid 36395363)
28. Popa I, Harris ME, Donello JE, Hope TJ (2002) CRM1-dependent function of a cis-acting RNA export element. Mol Cell Biol 22: 2057-2067. (Pubitemid 34224614)
29. Zufferey R, Donello JE, Trono D, Hope TJ (1999) Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 73: 2886-2892. (Pubitemid 29135675)
30. Jin YX, Zhao MH, Zheng Z, Kwon JS, Lee SK, et al. (2013) Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro. Reprod Fertil Dev. 2013 Jun 13.
31. Kwak SS, Jeung SH, Biswas D, Jeon YB, Hyun SH (2012) Effects of porcine granulocyte-macrophage colony-stimulating factor on porcine in vitro-fertilized embryos. Theriogenology 77: 1186-1197.
32. Biswas D, Jung EM, Jeung EB, Hyun SH (2011) Effects of vascular endothelial growth factor on porcine preimplantation embryos produced by in vitro fertilization and somatic cell nuclear transfer. Theriogenology 75: 256-267.
33. Song K, Hyun SH, Shin T, Lee E (2009) Post-activation treatment with demecolcine improves development of somatic cell nuclear transfer embryos in pigs by modifying the remodeling of donor nuclei. Mol Reprod Dev 76: 611-619.
34. Jin YX, Cui XS, Han YJ, Kim NH (2009) Leptin accelerates pronuclear formation following intracytoplasmic sperm injection of porcine oocytes: Possible role for MAP kinase inactivation. Anim Reprod Sci 115: 137-148.