Reclassifying the spectrum of septic patients using lactate: Severe sepsis, cryptic shock, vasoplegic shock and dysoxic shock;Reclassifcando o espectro de pacientes sépticos com o uso do lactato: Sepse grave, choque críptico, choque vasoplégico e choque disóxico

Revista Brasileira de Terapia Intensiva

Volumn 25, Issue 4, 2013, Pages 270-278

  Ranzani, Otavio Tavares ^a,b   Monteiro, Mariana Barbosa ^a   Ferreira, Elaine Maria ^c   Santos, Sergio Ricardo ^a   Machado, Flavia Ribeiro ^c,d   Noritomi, Danilo Teixeira ^a  

^a Services of Radiology of Hospital Nove de Julho   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Latin American Sepsis Institute   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Infection; Lactic acid; Sepsis; Shock

Indexed keywords

LACTIC ACID;

ADULT; AGED; BLOOD; BRAZIL; CLASSIFICATION; CLINICAL TRIAL; COHORT ANALYSIS; FEMALE; HOSPITAL; HUMAN; HYPERLACTATEMIA; HYPOTENSION; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; SEPSIS; SHOCK, SEPTIC; SURVIVAL RATE; VASOPLEGIA; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BRAZIL; COHORT STUDIES; FEMALE; HOSPITALS; HUMANS; HYPERLACTATEMIA; HYPOTENSION; LACTIC ACID; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; SEPSIS; SHOCK, SEPTIC; SURVIVAL RATE; VASOPLEGIA;

EID: 84898611861     PISSN: 0103507X     EISSN: 19824335     Source Type: Journal    
DOI: 10.5935/0103-507X.20130047     Document Type: Article

References (35)

1. Silva E, Pedro Mde A, Sogayar AC, Mohovic T, Silva CL, Janiszewski M, Cal RG, de Sousa E F, Abe T P, de Andrade J, de Matos JD, Rezende E, Assunção M, Avezum A, Rocha PC, de Matos G F, Bento AM, Corrêa AD, Vieira PC, Knobel E; Brazilian Sepsis Epidemiological Study. Brazilian Sepsis Epidemiological Study (BASES study). Crit Care. 2004;8(4):R251-60.
2. Silva E, Akamine N, Salomao R, Townsend SR, Dellinger R P, Levy M. Surviving sepsis campaign: a project to change sepsis trajectory. Endocr Metab Immune Disord Drug Targets. 2006;6(2):217-22.
3. Dellinger R.P., Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165-228.
4. Phua J, Koh Y, Du B, Tang YQ, Divatia JV, Tan CC, Gomersall CD, Faruq MO, Shrestha BR, Gia Binh N, Arabi YM, Salahuddin N, Wahyuprajitno B, Tu ML, Wahab AY, Hameed AA, Nishimura M, Procyshyn M, Chan YH; MOSAICS Study Group. Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ. 2011;342:d3245.
5. Sogayar AM, Machado FR, Rea-Neto A, Dornas A, Grion CM, Lobo SM, Tura BR, Silva CL, Cal RG, Beer I, Michels V, Safi J, Kayath M, Silva E; Costs Study Group - Latin American Sepsis Institute. A multicentre, prospective study to evaluate costs of septic patients in Brazilian intensive care units. Pharmacoeconomics. 2008;26(5):425-34.
6. Teles JM, Silva E, Westphal G, Filho RC, Machado FR Surviving sepsis campaign in Brazil. Shock. 2008;30 Suppl 1:47-52. Review.
7. Dellinger R.P., Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165-228.
8. Mikkelsen ME, Miltiades AN, Gaieski D F, Goyal M, Fuchs BD, Shah CV, et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med. 2009;37(5):1670-7.
9. Bakker J, Gris P, Coffernils M, Kahn RJ, Vincent JL Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg. 1996;171(2):221-6.
10. Bakker J, Jansen TC Don't take vitals, take a lactate. Intensive Care Med. 2007;33(11):1863-5.
11. Bakker J, Nijsten MW, Jansen TC Clinical use of lactate monitoring in critically ill patients. Ann Intensive Care. 2013;3(1):12.
12. Machado FR, Salomão R, Rigato O, Ferreira EM, Schettino G, Mohovic T, et al. Late recognition and illness severity are determinants of early death in severe septic patients. Clinics (Sao Paulo). 2013;68(5):586-91.
13. Jansen TC, van Bommel J, Schoonderbeek FJ, Sleeswijk Visser SJ, van der Klooster JM, Lima A P, Willemsen S P, Bakker J; LACTATE study group. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med. 2010;182(6):752-61.
14. Maciel AT, Park M. Unmeasured anions account for most of the metabolic acidosis in patients with hyperlactatemia. Clinics (Sao Paulo). 2007;62(1):55-62.
15. Noritomi D.T., Soriano FG, Kellum JA, Cappi SB, Biselli PJ, Libório AB, et al. Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study. Crit Care Med. 2009;37(10):2733-9.
16. Park M, Taniguchi LU, Noritomi DT, Libório AB, Maciel AT, Cruz-Neto LM. Clinical utility of standard base excess in the diagnosis and interpretation of metabolic acidosis in critically ill patients. Braz J Med Biol Res. 2008;41(3):241-9.
17. Hernandez G, Castro R, Romero C, de la Hoz C, Angulo D, Aranguiz I, et al. Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock? J Crit Care. 2011;26(4):435.e9-14.
18. Hernandez G, Bruhn A, Castro R, Pedreros C, Rovegno M, Kattan E, et al. Persistent Sepsis-Induced Hypotension without Hyperlactatemia: A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock. Crit Care Res Pract. 2012;2012:536852.
19. Puskarich MA, Trzeciak S, Shapiro NI, Heffner AC, Kline JA, Jones AE; Emergency Medicine Shock Research Network (EMSHOCKNET). Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation. 2011;82(10):1289-93.
20. Sterling SA, Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Summers RL, Jones AE; Emergency Medicine Shock Research Network (EMSHOCKNET). Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock. 2013;40(1):11-4.
21. Howell MD, Donnino M, Clardy P, Talmor D, Shapiro NI Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med. 2007;33(11):1892-9.
22. Noritomi DT, Ranzani OT, Monteiro MB, Ferreira EM, Santos SR, Leibel F, et al. Implementation of a multifaceted sepsis education program in an emerging country setting: clinical outcomes and cost-effectiveness in a long-term follow-up study. Intensive Care Med. 2013 Oct 22. [Epub ahead of print].
23. Latin American Sepsis Institute [Internet]. [cited 2012 feb 13]. Available from: http://www.sepsisnet.org/
24. Surviving Sepsis Campaign [Internet]. [cited 2012. Feb 13]. Available from: http://www.survivingsepsis.org.
25. Bone RC, Balk RA, Cerra FB, Dellinger R P, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644-55. Review.
26. Ranzani O.T., Battaini LC, Moraes CE, Prada L F, Pinaffi JV, Giannini F P, et al. Outcomes and organ dysfunctions of critically ill patients with systemic lupus erythematosus and other systemic rheumatic diseases. Braz J Med Biol Res. 2011;44(11):1184-93.
27. R Development Core Team. R: a language and environment for statistical computing. Viena, Austria: R Foundation for Statistical Computing; 2013.
28. Maciel AT, Noritomi DT, Park M. Metabolic acidosis in sepsis. Endocr Metab Immune Disord Drug Targets. 2010;10(3):252-7. Review.
29. Park M, Maciel AT, Noritomi DT, Brunialti MK, Salomão R, Schettino G P, et al. Is persistent hypotension after transient cardiogenic shock associated with an inflammatory response? Braz J Med Biol Res. 2008;41(8):648-56.
30. Wacharasint P, Nakada TA, Boyd JH, Russell JA, Walley KR Normal-range blood lactate concentration in septic shock is prognostic and predictive. Shock. 2012;38(1):4-10.
31. Gladden LB. Lactate metabolism: a new paradigm for the third millennium. J Physiol. 2004;558(Pt 1):5-30.
32. Levraut J, Ciebiera J P, Chave S, Rabary O, Jambou P, Carles M, et al. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med. 1998;157(4 Pt 1):1021-6.
33. Mizock BA, Falk JL Lactic acidosis in critical illness. Crit Care Med. 1992;20(1):80-93.
34. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-77.
35. Song YH, Shin TG, Kang MJ, Sim MS, Jo IJ, Song KJ, et al. Predicting factors associated with clinical deterioration of sepsis patients with intermediate levels of serum lactate. Shock. 2012;38(3):249-54.