Persistent sepsis-induced hypotension without hyperlactatemia: A distinct clinical and physiological profile within the spectrum of septic shock

Critical Care Research and Practice

Volumn 2012, Issue , 2012, Pages

  Hernandez, Glenn ^a,b   Bruhn, Alejandro ^b   Castro, Ricardo ^b   Pedreros, Cesar ^b   Rovegno, Maximiliano ^b   Kattan, Eduardo ^b   Veas, Enrique ^b   Fuentealba, Andrea ^b   Regueira, Tomas ^b   Ruiz, Carolina ^b   Ince, Can ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84866248598     PISSN: 20901305     EISSN: 20901313     Source Type: Journal    
DOI: 10.1155/2012/536852     Document Type: Article

References (32)

1. De Backer D., Lactic acidosis. Intensive Care Medicine 2003 29 5 699 702 2-s2.0-0038293075 (Pubitemid 36609559)
2. Philp A., Macdonald A. L., Watt P. W., Lactatea signal coordinating cell and systemic function. Journal of Experimental Biology 2005 208 24 4561 4575 2-s2.0-31044433796 10.1242/jeb.01961 (Pubitemid 43120002)
3. + ATPase activity and raised lactate concentrations in septic shock: a prospective study. The Lancet 2005 365 9462 871 875 2-s2.0-14744301896 10.1016/S0140-6736(05)71045-X (Pubitemid 40332165)
4. Shapiro N. I., Howell M. D., Talmor D., Nathanson L. A., Lisbon A., Wolfe R. E., Weiss J. W., Serum lactate as a predictor of mortality in emergency department patients with infection. Annals of Emergency Medicine 2005 45 5 524 528 2-s2.0-17844398255 10.1016/j.annemergmed.2004.12.006 (Pubitemid 40591784)
5. Arnold R. C., Shapiro N. I., Jones A. E., Schorr C., Pope J., Casner E., Parrillo J. E., Dellinger R. P., Trzeciak S., Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2009 32 1 35 39 2-s2.0-67749096073 10.1097/SHK.0b013e3181971d47
6. Nichol A. D., Egi M., Pettila V., Bellomo R., French C., Hart G., Davies A., Stachowski E., Reade M. C., Bailey M., Cooper D. J., Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study. Critical Care 2010 14 1, article R25 2-s2.0-77953000739 10.1186/cc8888
7. Levy M. M., Fink M. P., Marshall J. C., Abraham E., Angus D., Cook D., Cohen J., Opal S. M., Vincent J. L., Ramsay G., 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Critical Care Medicine 2003 31 4 1250 1256 2-s2.0-0037389094 10.1097/01.CCM.0000050454.01978.3B (Pubitemid 36444440)
8. Marchick M. R., Kline J. A., Jones A. E., The significance of non-sustained hypotension in emergency department patients with sepsis. Intensive Care Medicine 2009 35 7 1261 1264 2-s2.0-67649322442 10.1007/s00134-009-1448-x
9. Hernandez G., Castro R., Romero C., de la Hoz C., Angulo D., Aranguiz I., Larrondo J., Bujes A., Bruhn A., Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock? Journal of Critical Care 2011 26 4 435.e9 435.e14 2-s2.0-79960698424 10.1016/j.jcrc.2010.09.007
10. Dellinger R. P., Levy M. M., Carlet J. M., Bion J., Parker M. M., Jaeschke R., Reinhart K., Angus D. C., Brun-Buisson C., Beale R., Calandra T., Dhainaut J. F., Gerlach H., Harvey M., Marini J. J., Marshall J., Ranieri M., Ramsay G., Sevransky J., Thompson B. T., Townsend S., Vender J. S., Zimmerman J. L., Vincent J. L., Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Medicine 2008 34 1 17 60 2-s2.0-38349058657 10.1007/s00134-007-0934-2
11. Hernandez G., Bruhn A., Romero C., Javier Larrondo F., De La Fuente R., Castillo L., Bugedo G., Management of septic shock with a norepinephrine-based haemodynamic algorithm. Resuscitation 2005 66 1 63 69 2-s2.0-21544459904 10.1016/j.resuscitation.2005.01.009 (Pubitemid 40922761)
12. Hernandez G., Bruhn A., Romero C., Larrondo F. J., De La Fuente R., Cornejo R., Castillo L., Bugedo G., Implementation of a norepinephrine-based protocol for management of septic shock: a pilot feasibility study. The Journal of Trauma 2006 60 1 77 81 2-s2.0-33644938419
13. Cornejo R., Downey P., Castro R., Romero C., Regueira T., Vega J., Castillo L., Andresen M., Dougnac A., Bugedo G., Hernandez G., High-volume hemofiltration as salvage therapy in severe hyperdynamic septic shock. Intensive Care Medicine 2006 32 5 713 722 2-s2.0-33646416536 10.1007/s00134-006-0118-5
14. Castro R., Regueira T., Aguirre M. L., Llanos O. P., Bruhn A., Bugedo G., Dougnac A., Castillo L., Andresen M., Hernández G., An evidence-based resuscitation algorithm applied from the emergency room to the ICU improves survival of severe septic shock. Minerva Anestesiologica 2008 74 6 223 231 2-s2.0-47849093761 (Pubitemid 352037782)
15. Marik P. E., Monnet X., Teboul J. L., Hemodynamic parameters to guide fluid therapy. Annals of Intensive Care 2011 1, article 1
16. Malbrain M. L. N. G., Cheatham M. L., Kirkpatrick A., Sugrue M., Parr M., De Waele J., Balogh Z., Leppäniemi A., Olvera C., Ivatury R., D'Amours S., Wendon J., Hillman K., Johansson K., Kolkman K., Wilmer A., Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions. Intensive Care Medicine 2006 32 11 1722 1732 2-s2.0-33750217742 10.1007/s00134-006-0349-5 (Pubitemid 44607359)
17. De Backer D., Hollenberg S., Boerma C., Goedhart P., Büchele G., Ospina-Tascon G., Dobbe I., Ince C., How to evaluate the microcirculation: report of a round table conference. Critical Care 2007 11, article R101 2-s2.0-35148888322 10.1186/cc6118 (Pubitemid 47534913)
18. van der Poll T., De Boer J. D. D., Levi M., The effect of inflammation on coagulation and vice versa. Current Opinion in Infectious Diseases 2011 24 3 273 278 2-s2.0-79955524498 10.1097/QCO.0b013e328344c078
19. Vincent J. L., Microvascular endothelial dysfunction: a renewed appreciation of sepsis pathophysiology. Critical Care 2001 5 supplement 2 S1 S5 2-s2.0-0035229403
20. Hartemink K. J., Hack C. E., Groeneveld A. B. J., Relation between coagulation/fibrinolysis and lactate in the course of human septic shock. Journal of Clinical Pathology 2010 63 11 1021 1026 2-s2.0-78149361055 10.1136/jcp.2010.079707
21. Levi M., Löwenberg E. C., Thrombocytopenia in critically ill patients. Seminars in Thrombosis and Hemostasis 2008 34 5 417 424 2-s2.0-55049123108 10.1055/s-0028-1092871
22. Ince C., The microcirculation is the motor of sepsis. Critical Care 2005 9 4 S13 S19 2-s2.0-27144553471 10.1186/cc3753 (Pubitemid 41498527)
23. Boerma E. C., Kuiper M. A., Kingma W. P., Egbers P. H., Gerritsen R. T., Ince C., Disparity between skin perfusion and sublingual microcirculatory alterations in severe sepsis and septic shock: a prospective observational study. Intensive Care Medicine 2008 34 7 1294 1298 2-s2.0-46149087563 10.1007/s00134-008-1007-x (Pubitemid 351904286)
24. Boerma E. C., van der Voort P. H. J., Spronk P. E., Ince C., Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Critical Care Medicine 2007 35 4 1055 1060 2-s2.0-34247171377 10.1097/01.CCM.0000259527.89927.F9 (Pubitemid 46598955)
25. Trzeciak S., Bajaj J., Guglielmi M., Microcirculatory perfusion in severe sepsis does not correlate with lactate. Critical Care Medicine 2004 32 12, article A156
26. De Backer D., Creteur J., Dubois M. J., Sakr Y., Koch M., Verdant C., Vincent J. L., The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Critical Care Medicine 2006 34 2 403 408 2-s2.0-31344453457 10.1097/01.CCM.0000198107. 61493.5A (Pubitemid 43145619)
27. Ospina-Tascon G., Neves A. P., Occhipinti G., Donadello K., Büchele G., Simion D., Chierego M. L., Silva T. O., Fonseca A., Vincent J. L., De Backer D., Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Medicine 2010 36 6 949 955 2-s2.0-77954456169 10.1007/s00134-010-1843-3
28. Dubin A., Pozo M. O., Casabella C. A., Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Critical Care 2009 13 3, article R92 2-s2.0-67650345732 10.1186/cc7922
29. Ruiz C., Hernandez G., Godoy C., Downey P., Andresen M., Bruhn A., Sublingual microcirculatory changes during high-volume hemofiltration in hyperdynamic septic shock patients. Critical Care 2010 14 5, article 170 2-s2.0-77957158965 10.1186/cc9271
30. Jhanji S., Stirling S., Patel N., Hinds C. J., Pearse R. M., The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Critical Care Medicine 2009 37 6 1961 1966 2-s2.0-66449113461
31. Trzeciak S., Dellinger R. P., Parrillo J. E., Guglielmi M., Bajaj J., Abate N. L., Arnold R. C., Colilla S., Zanotti S., Hollenberg S. M., Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Annals of Emergency Medicine 2007 49 1 88 98.e2 2-s2.0-33845872563 10.1016/j.annemergmed.2006.08.021 (Pubitemid 46019834)
32. Boerma E. C., Koopmans M., Konijn A., Kaiferova K., Bakker A. J., Van Roon E. N., Buter H., Bruins N., Egbers P. H., Gerritsen R. T., Koetsier P. M., Kingma W. P., Kuiper M. A., Ince C., Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. Critical Care Medicine 2010 38 1 93 100 2-s2.0-74049118733 10.1097/CCM.0b013e3181b02fc1