In vivo and in vitro studies of Th17 response to specific immunotherapy in house dust mite-induced allergic rhinitis patients

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Li, Chun Wei ^a   Lu, Han Gui ^b   Chen, De Hua ^b   Lin, Zhi Bin ^b   Wang, De Yun ^a   Li, Tian Ying ^b  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 6; MESSENGER RNA; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR RELATED ORPHAN RECEPTOR C; UNCLASSIFIED DRUG; CYTOKINE;

ADULT; ALLERGEN SPECIFIC IMMUNOTHERAPY; ALLERGIC RHINITIS; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CELL STIMULATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HOUSE DUST ALLERGY; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTOPOIESIS; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; SENSITIZATION; SYMPTOMATOLOGY; TH1 CELL; TH17 CELL; TH2 CELL; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; CLINICAL TRIAL; GENE EXPRESSION REGULATION; GENETICS; IMMUNITY; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM; PARASITOLOGY; PYROGLYPHIDAE; REAL TIME POLYMERASE CHAIN REACTION; VISUAL ANALOG SCALE;

ADULT; ANIMALS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY; IMMUNOTHERAPY; LYMPHOCYTE SUBSETS; MALE; PYROGLYPHIDAE; REAL-TIME POLYMERASE CHAIN REACTION; RHINITIS, ALLERGIC; RNA, MESSENGER; TH17 CELLS; VISUAL ANALOG SCALE;

EID: 84898603189     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091950     Document Type: Article

References (24)

1. Borish L (2003) Allergic rhinitis: systemic inflammation and implications for management. J Allergy Clin Immunol 112: 1021-1031.
2. Hansen I, Klimek L, Mösges R, Hörmann K (2004) Mediators of inflammation in the early and the late phase of allergic rhinitis. Curr Opin Allergy Clin Immunol 4: 159-163. (Pubitemid 38685515)
3. Schmidt-Weber CB, Akdis M, Akdis CA (2007) TH17 cells in the big picture of immunology. J Allergy Clin Immunol 120: 247-254. (Pubitemid 47102403)
4. Dong C (2008) TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 8: 337-348.
5. Crome SQ, Wang AY, Levings MK (2010) Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol 159: 109-119.
6. Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, et al. (2009) Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med 180: 720-730.
7. Ciprandi G, Filaci G, Battaglia F, Fenoglio D (2010) Peripheral Th-17 cells in allergic rhinitis: New evidence. Int Immunopharmacol 10: 226-229.
8. Ciprandi G, De Amici M, Murdaca G, Fenoglio D, Ricciardolo F, et al. (2009) Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. Allergy 64: 1375-1378.
9. Zhou L, Littman DR (2009) Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol 21: 146-152.
10. Pipet A, Botturi K, Pinot D, Vervloet D, Magnan A (2009) Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy. Respir Med 103: 800-812.
11. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, et al. (2008) Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63: 8-160.
12. Qu SH, Li TY, Ou ZY, Lin ZB, Chen YQ, et al. (2005) Expression of T-bet and its relation with IgE and eosinophil cationic protein in patients with allergic rhinitis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 40: 908-911.
13. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
14. Park SJ, Lee YC (2010) Interleukin-17 regulation: an attractive therapeutic approach for asthma. Respir Res 11: 78.
15. Louten J, Boniface K, de Waal Malefyt R (2009) Development and function of TH17 cells in health and disease. J Allergy Clin Immunol 123: 1004-1011.
16. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133. (Pubitemid 44380299)
17. Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, et al. (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8: 967-974. (Pubitemid 47300011)
18. Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, et al. (2009) IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol 183: 2435-2443.
19. Zuberbier T, Bachert C, Bousquet PJ, Passalacqua G, Walter Canonica G, et al. (2010) GA2 LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma. Allergy 65: 1525-1530.
20. Ciprandi G, De Amici M, Negrini S, Marseglia G, Tosca MA (2009) TGF-beta and IL-17 serum levels and specific immunotherapy. Int Immunopharmacol 9: 1247-1249.
21. Nouri-Aria KT, Wachholz PA, Francis JN, Jacobson MR, Walker SM, et al. (2004) Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 172: 3252-3259. (Pubitemid 38263717)
22. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, et al. (2004) Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 199: 1567-1575. (Pubitemid 38780411)
23. Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, et al. (1995) Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J Immunol 154: 4187-4194.
24. Littman DR, Rudensky AY (2010) Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140: 845-858.