A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages

  Reddy, Elizabeth A ^a,b   Njau, Boniface N ^b   Morpeth, Susan C ^d   Lancaster, Kathryn E ^e   Tribble, Alison C ^f   Maro, Venance P ^b,c   Msuya, Levina J ^b,c   Morrissey, Anne B ^a   Kibiki, Gibson S ^b,c   Thielman, Nathan M ^a,g   Cunningham, Coleen K ^a   Schimana, Werner ^h   Shao, John F ^b,c   Chow, Shein Chung ⁱ   Stout, Jason E ^a   Crump, John A ^a,c,f   Bartlett, John A ^a,c,f   Hamilton, Carol D ^a,j  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b KILIMANJARO CHRISTIAN MEDICAL CENTRE   (Tanzania)

^c KILIMANJARO CHRISTIAN MEDICAL UNIVERSITY COLLEGE   (Tanzania)

^d KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^e University of North Carolina at Chapel Hill   (United States)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^g DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION   (United States)

ⁱ DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^j FAMILY HEALTH INTERNATIONAL   (United States)

more..

Author keywords

Adult; Child; Diagnosis; Health resources; HIV; Mycobacterium tuberculosis; Sputum microbiology

Indexed keywords

TUBERCULOSTATIC AGENT;

ACID FAST BACTERIUM; ADULT; ARTICLE; BACTERIUM CULTURE; CHILD; CONTROLLED STUDY; DIAGNOSTIC KIT; DIAGNOSTIC TEST ACCURACY STUDY; DNA PROBE; FEMALE; FOLLOW UP; GASTRIC SUCTION; HUMAN; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MORTALITY; MYCOBACTERIUM TUBERCULOSIS; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SPUTUM ANALYSIS; SPUTUM SMEAR; TANZANIA; TUBERCULIN TEST; COMPLICATION; DECISION MAKING; DIAGNOSTIC TEST; HEALTH CARE QUALITY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; MICROBIOLOGICAL EXAMINATION; MIDDLE AGED; TREATMENT OUTCOME; TUBERCULOSIS; TUBERCULOSIS, PULMONARY;

ADULT; ANTITUBERCULAR AGENTS; BACTERIOLOGICAL TECHNIQUES; CHILD, PRESCHOOL; DECISION MAKING; DIAGNOSTIC TESTS, ROUTINE; FEMALE; HIV INFECTIONS; HUMANS; INFANT; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; STANDARD OF CARE; TANZANIA; TREATMENT OUTCOME; TUBERCULOSIS; TUBERCULOSIS, PULMONARY;

EID: 84898602179     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-14-89     Document Type: Article

References (32)

1. Global Tuberculosis Control: WHO Report 2011. [http://www.who.int/tb/publications/global_report/2011/gtbr11_executive_summary.pdf].
2. Corbett EL, Marston B, Churchyard GJ, De Cock KM. Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment. Lancet 2006, 367(9514):926-937. 10.1016/S0140-6736(06)68383-9, 16546541.
3. Getahun H, Kittikraisak W, Heilig CM, Corbett EL, Ayles H, Cain KP, Grant AD, Churchyard GJ, Kimerling M, Shah S, et al. Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies. PLoS Med 2011, 8(1):e1000391. 10.1371/journal.pmed.1000391, 3022524, 21267059.
4. WHO Report: Global Tuberculosis Control 2008. [http://www.stoptb.org/assets/documents/countries/acsm/United%20Republic%20of%20Tanzania.pdf].
5. Getahun H, Harrington M, O'Brien R, Nunn P. Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes. Lancet 2007, 369(9578):2042-2049. 10.1016/S0140-6736(07)60284-0, 17574096.
6. Holtz TH, Kabera G, Mthiyane T, Zingoni T, Nadesan S, Ross D, Allen J, Chideya S, Sunpath H, Rustomjee R. Use of a WHO-recommended algorithm to reduce mortality in seriously ill patients with HIV infection and smear-negative pulmonary tuberculosis in South Africa: an observational cohort study. Lancet Infect Dis 2011, 11(7):533-540. 10.1016/S1473-3099(11)70057-3, 21514234.
7. Kufa T, Mngomezulu V, Charalambous S, Hanifa Y, Fielding K, Grant AD, Wada N, Chaisson RE, Churchyard GJ, Gounder CR. Undiagnosed tuberculosis among HIV clinic attendees: association with antiretroviral therapy and implications for intensified case finding, isoniazid preventive therapy, and infection control. J Acquir Immune Defic Syndr 2012, 60(2):e22-e28. 10.1097/QAI.0b013e318251ae0b, 22627184.
8. Monkongdee P, McCarthy KD, Cain KP, Tasaneeyapan T, Nguyen HD, Nguyen TN, Nguyen TB, Teeratakulpisarn N, Udomsantisuk N, Heilig C, et al. Yield of acid-fast smear and mycobacterial culture for tuberculosis diagnosis in people with human immunodeficiency virus. Am J Respir Crit Care Med 2009, 180(9):903-908. 10.1164/rccm.200905-0692OC, 19628775.
9. Siddiqi K, Lambert ML, Walley J. Clinical diagnosis of smear-negative pulmonary tuberculosis in low-income countries: the current evidence. Lancet Infect Dis 2003, 3(5):288-296. 10.1016/S1473-3099(03)00609-1, 12726978.
10. Swai HF, Mugusi FM, Mbwambo JK. Sputum smear negative pulmonary tuberculosis: sensitivity and specificity of diagnostic algorithm. BMC Res Notes 2011, 4:475. 10.1186/1756-0500-4-475, 3216301, 22044882.
11. Minion J, Leung E, Menzies D, Pai M. Microscopic-observation drug susceptibility and thin layer agar assays for the detection of drug resistant tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2010, 10(10):688-698. 10.1016/S1473-3099(10)70165-1, 20813587.
12. Dowdy DW, Chaisson RE, Maartens G, Corbett EL, Dorman SE. Impact of enhanced tuberculosis diagnosis in South Africa: a mathematical model of expanded culture and drug susceptibility testing. Proc Natl Acad Sci USA 2008, 105(32):11293-11298. 10.1073/pnas.0800965105, 2516234, 18695217.
13. Paglia MG, Bevilacqua N, Haji HS, Vairo F, Girardi E, Nicastri E, Muhsin J, Racalbuto V, Jiddawi MS, Ippolito G. Improvement of tuberculosis laboratory capacity on pemba island, zanzibar: a health cooperation project. PLoS One 2012, 7(8):e44109. 10.1371/journal.pone.0044109, 3428332, 22952891.
14. Nansera D, Bajunirwe F, Elyanu P, Asiimwe C, Amanyire G, Graziano FM. Mortality and loss to follow-up among tuberculosis and HIV co-infected patients in rural southwestern Uganda. Int J Tuberc Lung Dis 2012
15. Henegar C, Behets F, Vanden Driessche K, Tabala M, Bahati E, Bola V, Van Rie A. Mortality among tuberculosis patients in the Democratic Republic of Congo. Int J Tuberc Lung Dis 2012, 16(9):1199-1204. 10.5588/ijtld.11.0613, 22871326.
16. Macpherson P, Dimairo M, Bandason T, Zezai A, Munyati SS, Butterworth AE, Mungofa S, Rusakaniko S, Fielding K, Mason PR, et al. Risk factors for mortality in smear-negative tuberculosis suspects: a cohort study in Harare, Zimbabwe. Int J Tuberc Lung Dis 2011, 15(10):1390-1396. 10.5588/ijtld.11.0056, 3272461, 22283900.
17. Nissen TN, Rose MV, Kimaro G, Bygbjerg IC, Mfinanga SG, Ravn P. Challenges of loss to follow-up in tuberculosis research. PLoS One 2012, 7(7):e40183. 10.1371/journal.pone.0040183, 3395690, 22808114.
18. Lee CH, Kim WJ, Yoo CG, Kim YW, Han SK, Shim YS, Yim JJ. Response to empirical anti-tuberculosis treatment in patients with sputum smear-negative presumptive pulmonary tuberculosis. Respiration 2005, 72(4):369-374. 10.1159/000086250, 16088279.
19. National Bureau of Statistics Tanzania Demographic and Health Survey 2005, 381. Dar es Salaam: http://www.nbs.go.tz/, National Bureau of Statistics.
20. Apers L, Wijarajah C, Mutsvangwa J, Chigara N, Mason P, van der Stuyft P. Accuracy of routine diagnosis of pulmonary tuberculosis in an area of high HIV prevalence. Int J Tuberc Lung Dis 2004, 8(8):945-951.
21. Scott B, Schmid M, Nettleman MD. Early identification and isolation of inpatients at high risk for tuberculosis. Arch Intern Med 1994, 154(3):326-330. 10.1001/archinte.1994.00420030136014, 8297200.
22. Cohen R, Muzaffar S, Capellan J, Azar H, Chinikamwala M. The validity of classic symptoms and chest radiographic configuration in predicting pulmonary tuberculosis. Chest 1996, 109(2):420-423. 10.1378/chest.109.2.420, 8620716.
23. El-Solh A, Mylotte J, Sherif S, Serghani J, Grant BJ. Validity of a decision tree for predicting active pulmonary tuberculosis. Am J Respir Crit Care Med 1997, 155(5):1711-1716. 10.1164/ajrccm.155.5.9154881, 9154881.
24. Wisnivesky JP, Kaplan J, Henschke C, McGinn TG, Crystal RG. Evaluation of clinical parameters to predict Mycobacterium tuberculosis in inpatients. Arch Intern Med 2000, 160(16):2471-2476. 10.1001/archinte.160.16.2471, 10979058.
25. Miller LG, Asch SM, Yu EI, Knowles L, Gelberg L, Davidson P. A population-based survey of tuberculosis symptoms: how atypical are atypical presentations?. Clin Infect Dis 2000, 30(2):293-299. 10.1086/313651, 10671331.
26. Tattevin P, Casalino E, Fleury L, Egmann G, Ruel M, Bouvet E. The validity of medical history, classic symptoms, and chest radiographs in predicting pulmonary tuberculosis: derivation of a pulmonary tuberculosis prediction model. Chest 1999, 115(5):1248-1253. 10.1378/chest.115.5.1248, 10334135.
27. Bock NN, McGowan JE, Ahn J, Tapia J, Blumberg HM. Clinical predictors of tuberculosis as a guide for a respiratory isolation policy. Am J Respir Crit Care Med 1996, 154(5):1468-1472. 10.1164/ajrccm.154.5.8912766, 8912766.
28. Mtei L, Matee M, Herfort O, Bakari M, Horsburgh CR, Waddell R, Cole BF, Vuola JM, Tvaroha S, Kreiswirth B, et al. High rates of clinical and subclinical tuberculosis among HIV-infected ambulatory subjects in Tanzania. Clin Infect Dis 2005, 40(10):1500-1507. 10.1086/429825, 15844073.
29. Ole-Nguyaine S, Crump JA, Kibiki GS, Kiang K, Taylor J, Schimana W, Bartlett JA, Shao JF, Hamilton JD, Thielman NM. HIV-associated morbidity, mortality and diagnostic testing opportunities among inpatients at a referral hospital in northern Tanzania. Ann Trop Med Parasitol 2004, 98(2):171-179. 10.1179/000349804225003163, 15035727.
30. Kassa A, Teka A, Shewaamare A, Jerene D. Incidence of tuberculosis and early mortality in a large cohort of HIV infected patients receiving antiretroviral therapy in a tertiary hospital in Addis Ababa, Ethiopia. Trans R Soc Trop Med Hyg 2012, 106(6):363-370. 10.1016/j.trstmh.2012.03.002, 22521216.
31. Lofgren SM, Kirsch EJ, Maro VP, Morrissey AB, Msuya LJ, Kinabo GD, Saganda W, Diefenthal HC, Ramadhani HO, Wheat LJ, et al. Histoplasmosis among hospitalized febrile patients in northern Tanzania. Trans R Soc Trop Med Hyg 2012, 106(8):504-507. 10.1016/j.trstmh.2012.05.009, 3392419, 22742942.
32. Tostmann A, Boeree MJ, Aarnoutse RE, de Lange WC, van der Ven AJ, Dekhuijzen R. Antituberculosis drug-induced hepatotoxicity: concise up-to-date review. J Gastroenterol Hepatol 2008, 23(2):192-202. 10.1111/j.1440-1746.2007.05207.x, 17995946.