Slowed muscle oxygen uptake kinetics with raised metabolism are not dependent on blood flow or recruitment dynamics

Journal of Physiology

Volumn 592, Issue 8, 2014, Pages 1857-1871

  Wüst, Rob C I ^a,b   Mcdonald, James R ^c   Sun, Yi ^c,d   Ferguson, Brian S ^c   Rogatzki, Matthew J ^c   Spires, Jessica ^e   Kowalchuk, John M ^f   Gladden, L Bruce ^c   Rossiter, Harry B ^a,g  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c AUBURN UNIVERSITY   (United States)

^d EAST CHINA NORMAL UNIVERSITY   (China)

^e Case Western Reserve University   (United States)

^f UNIVERSITY OF WESTERN ONTARIO   (Canada)

^g LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ADULT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; GASTROCNEMIUS MUSCLE; MALE; METABOLIC RATE; MUSCLE BLOOD FLOW; MUSCLE EXCITATION; MUSCLE ISOMETRIC CONTRACTION; MUSCLE METABOLISM; MUSCLE TETANIC CONTRACTION; NONHUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; SCIATIC NERVE; SKELETAL MUSCLE OXYGEN UPTAKE; ANIMAL; BLOOD FLOW; EXERCISE; HEMODYNAMICS; INNERVATION; METABOLISM; MUSCLE CONTRACTION; NEUROPHYSIOLOGICAL RECRUITMENT; OXYGEN CONSUMPTION; PHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION;

ANIMALS; DOGS; FEMALE; HEMODYNAMICS; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL EXERTION; RECRUITMENT, NEUROPHYSIOLOGICAL; REGIONAL BLOOD FLOW; SCIATIC NERVE;

EID: 84898548062     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.267476     Document Type: Article

References (51)

1. 2 and fatigue during repetitive isometric contractions in situ. J Appl Physiol (1985) 84, 1909-1916.
2. Benson AP, Grassi B & Rossiter HB (2013). A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans. J Appl Physiol (1985) 115, 743-755.
3. 2 uptake kinetics on transition to moderate-intensity exercise in humans independently of work rate. Exp Physiol 96, 1049-1061.
4. 2 uptake kinetics during very heavy intensity exercise in boys and men. Respir Physiol Neurobiol 180, 223-229.
5. Brittain CJ, Rossiter HB, Kowalchuk JM & Whipp BJ (2001). Effect of prior metabolic rate on the kinetics of oxygen uptake during moderate-intensity exercise. Eur J Appl Physiol 86, 125-134.
6. Chance B & Williams GR (1955). Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 217, 383-393.
7. Chess DJ, Billings E, Covian R, Glancy B, French S, Taylor J, de Bari H, Murphy E & Balaban RS (2013). Optical spectroscopy in turbid media using an integrating sphere: mitochondrial chromophore analysis during metabolic transitions. Anal Biochem 439, 161-172.
8. 2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise. J Appl Physiol (1985) 95, 113-120.
9. 2 debt contracted in submaximal exercise. J Appl Physiol 29, 547-551.
10. 2 uptake kinetics during work-to-work exercise transitions. J Appl Physiol 109, 1148-1154.
11. 2 uptake dynamics during 'work-to-work' knee-extension exercise. Respir Physiol Neurobiol 172, 15-23.
12. 2 uptake kinetics during transitions to high-intensity exercise from an elevated baseline. Respir Physiol Neurobiol 169, 16-23.
13. 2 uptake kinetics during supine 'work-to-work' high-intensity cycle exercise. J Appl Physiol 108, 283-292.
14. 2 uptake kinetics during transitions to high-intensity exercise from an elevated baseline. J Appl Physiol 105, 538-546.
15. 2+ in the regulation of cellular energetics. Biochemistry 51, 2959-2973.
16. Glancy B, Barstow T & Willis WT (2008). Linear relation between time constant of oxygen uptake kinetics, total creatine, and mitochondrial content in vitro. Am J Physiol Cell Physiol 294, C79-C87.
17. 2 delivery. J Appl Physiol 112, 9-19.
18. 2 utilization? New insights into an old issue. Med Sci Sports Exerc 32, 108-116.
19. 2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 85, 1394-1403.
20. Grassi B, Pogliaghi S, Rampichini S, Quaresima V, Ferrari M, Marconi C & Cerretelli P (2003). Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humans. J Appl Physiol (1985) 95, 149-158.
21. 2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80, 988-998.
22. 2 uptake kinetics during subsequent moderate-intensity exercise in healthy young adults. J Physiol 577, 985-996.
23. 2 and computer-controlled pump perfusion as novel techniques to study skeletal muscle metabolism in situ. J Appl Physiol 108, 705-712.
24. Hodson-Tole EF & Wakeling JM (2009). Motor unit recruitment for dynamic tasks: current understanding and future directions. J Comp Physiol 179, 57-66.
25. 2 in regulating tissue respiration in dog muscle working in situ. J Appl Physiol 73, 728-736.
26. Hughson RL & Morrissey M (1982). Delayed kinetics of respiratory gas exchange in the transition from prior exercise. J Appl Physiol 52, 921-929.
27. Jeneson JA, Schmitz JP, van den Broek NM, van Riel NA, Hilbers PA, Nicolay K & Prompers JJ (2009). Magnitude and control of mitochondrial sensitivity to ADP. Am J Physiol Endocrinol Metab 297, E774-E784.
28. Jeneson JA, Wiseman RW, Westerhoff HV & Kushmerick MJ (1996). The signal transduction function for oxidative phosphorylation is at least second order in ADP. J Biol Chem 271, 27995-27998.
29. Jones AM, Fulford J & Wilkerson DP (2008a). Influence of prior exercise on muscle [phosphorylcreatine] and deoxygenation kinetics during high-intensity exercise in men. Exp Physiol 93, 468-478.
30. Jones AM, Wilkerson DP & Fulford J (2008b). Muscle [phosphocreatine] dynamics following the onset of exercise in humans: the influence of baseline work-rate. J Physiol 586, 889-898.
31. 2max. Med Sci Sports Exerc 28, 367.
32. Koga S, Poole DC, Ferreira LF, Whipp BJ, Kondo N, Saitoh T, Ohmae E & Barstow TJ (2007). Spatial heterogeneity of quadriceps muscle deoxygenation kinetics during cycle exercise. J Appl Physiol (1985) 103, 2049-2056.
33. Korzeniewski B (2007). Regulation of oxidative phosphorylation through parallel activation. Biophys Chem 129, 93-110.
34. Kushmerick MJ, Meyer RA & Brown TR (1992). Regulation of oxygen consumption in fast- and slow-twitch muscle. Am J Physiol Cell Physiol 263, C598-C606.
35. 2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain. J Appl Physiol 99, 1822-1834.
36. Maxwell LC, Barclay JK, Mohrman DE & Faulkner JA (1977). Physiological characteristics of skeletal muscles of dogs and cats. Am J Physiol Cell Physiol 233, C14-C18.
37. Meyer R & Foley J (1996). Cellular processes integrating the metabolic response to exercise. Handbook of Physiology - Exercise: Regulation and Integration of Multiple Systems 12, 841-869.
38. Meyer RA (1988). A linear model of muscle respiration explains monoexponential phosphocreatine changes. Am J Physiol Cell Physiol 254, C548-C553.
39. Meyer RA (1989). Linear dependence of muscle phosphocreatine kinetics on total creatine content. Am J Physiol Cell Physiol 257, C1149-C1157.
40. Poole DC & Jones AM (2012). Oxygen uptake kinetics. Compr Physiol 2, 933-996.
41. Rossiter H (2011). Exercise: Kinetic considerations for gas exchange. Compr Physiol 1, 203-244.
42. Rossiter HB, Ward SA, Kowalchuk JM, Howe FA, Griffiths JR & Whipp BJ (2001). Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans. J Physiol 537, 291-303.
43. Schmitz JP, Jeneson JA, van Oorschot JW, Prompers JJ, Nicolay K, Hilbers PA & van Riel NA (2012). Prediction of muscle energy states at low metabolic rates requires feedback control of mitochondrial respiratory chain activity by inorganic phosphate. PLoS ONE 7, e34118.
44. Schuder S, Wittenberg JB, Haseltine B & Wittenberg BA (1979). Spectrophotometric determination of myoglobin in cardiac and skeletal muscle: separation from hemoglobin by subunit-exchange chromatography. Anal Biochem 92, 473-481.
45. Stainsby WN & Otis AB (1964). Blood flow, blood oxygen tension, oxygen uptake, and oxygen transport in skeletal muscle. Am J Physiol 206, 858-866.
46. Whipp BJ & Rossiter HB (2005). The kinetics of oxygen uptake. Physiological inferences from the parameters. In Oxygen Uptake Kinetics in Sport, Exercise and Medicine, ed. Jones AM & Poole DC, pp. 62-94. Routledge, Oxon.
47. 2 uptake on-kinetics during severe intensity exercise. Respir Physiol Neurobiol 152, 204-219.
48. 2 uptake, but not muscle deoxygenation, during moderate-intensity exercise transitions initiated from low and elevated baseline metabolic rates. J Appl Physiol (1985) 114, 1550-1562.
49. Wüst RCI, Grassi B, Hogan MC, Howlett RA, Gladden LB & Rossiter HB (2011). Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle. J Physiol 589, 3995-4009.
50. Wüst RCI, Jaspers RT, van Heijst AF, Hopman MT, Hoofd LJ, van der Laarse WJ & Degens H (2009). Region-specific adaptations in determinants of rat skeletal muscle oxygenation to chronic hypoxia. Am J Physiol Heart Circ Physiol 297, H364-H374.
51. Wüst RCI, van der Laarse WJ & Rossiter HB (2013). On-off asymmetries in oxygen consumption kinetics of single Xenopus laevis skeletal muscle fibres suggest higher-order control. J Physiol 591, 731-744.