A raised metabolic rate slows pulmonary O2 uptake kinetics on transition to moderate-intensity exercise in humans independently of work rate

Experimental Physiology

Volumn 96, Issue 10, 2011, Pages 1049-1061

  Bowen, T Scott ^a   Murgatroyd, Scott R ^a   Cannon, Daniel T ^a   Cuff, Thomas J ^b   Lainey, Allison F ^b   Marjerrison, Andrea D ^b   Spencer, Matthew D ^b   Benson, Alan P ^a   Paterson, Donald H ^b   Kowalchuk, John M ^b   Rossiter, Harry B ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREATHING; COMPUTER MODEL; COMPUTER SIMULATION; DYNAMICS; ERGOMETRY; EXERCISE; HUMAN; IN VIVO STUDY; MALE; MASS SPECTROMETRY; METABOLIC RATE; METABOLISM; MODERATE INTENSITY EXERCISE; NORMAL HUMAN; OXYGEN CONSUMPTION; OXYGENATION; PULMONARY OXYGEN UPTAKE; WORK; WORK RATE;

EID: 80052864398     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2011.058321     Document Type: Article

References (44)

1. Barstow TJ, Buchthal SD, Zanconato S & Cooper DM (1994). Changes in potential controllers of human skeletal muscle respiration during incremental calf exercise. J Appl Physiol 77, 2169-2176.
2. 2 uptakes by circulatory dynamics during exercise. J Appl Physiol 68, 979-989.
3. Beaver WL, Lamarra N & Wasserman K (1981). Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol 51, 1662-1675.
4. Beaver WL, Wasserman K & Whipp BJ (1986). A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60, 2020-2027.
5. Bigland-Ritchie B & Woods JJ (1974). Integrated EMG and oxygen uptake during dynamic contractions of human muscles. J Appl Physiol 36, 475-479.
6. Brittain CJ, Rossiter HB, Kowalchuk JM & Whipp BJ (2001). Effect of prior metabolic rate on the kinetics of oxygen uptake during moderate-intensity exercise. Eur J Appl Physiol 86, 125-134.
7. Cannon DT, White AC, Andriano MF, Kolkhorst FW & Rossiter HB (2011). Skeletal muscle fatigue preceeds the slow component of oxygen uptake kinetics during exercise in humans. J Physiol 589, 727-739.
8. Chance B & Williams GR (1956). The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem 17, 65-134.
9. 2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise. J Appl Physiol 95, 113-120.
10. Diamond LB, Casaburi R, Wasserman K & Whipp BJ (1977). Kinetics of gas exchange and ventilation in transitions from rest or prior exercise. J Appl Physiol 43, 704-708.
11. 2 uptake kinetics during work-to-work exercise transitions. J Appl Physiol 109, 1148-1154.
12. 2 uptake kinetics during transitions to high-intensity exercise from an elevated baseline. J Appl Physiol 105, 538-546.
13. di Prampero PE, Mahler PB, Giezendanner D & Cerretelli P (1989). Effects of priming exercise on VO2 kinetics and O2 deficit at the onset of stepping and cycling. J Appl Physiol 66, 2023-2031.
14. Fukuba Y, Ohe Y, Miura A, Kitano A, Endo M, Sato H, Miyachi M, Koga S & Fukuda O (2004). Dissociation between the time courses of femoral artery blood flow and pulmonary during repeated bouts of heavy knee extension exercise in humans. Exp Physiol 89, 243-253.
15. Glancy B, Barstow T & Willis WT (2008). Linear relation between time constant of oxygen uptake kinetics, total creatine, and mitochondrial content in vitro. Am J Physiol Cell Physiol 294, C79-C87.
16. 2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80, 988-998.
17. Hughson RL & Inman MD (1986). Oxygen uptake kinetics from ramp work tests: variability of single test values. J Appl Physiol 61, 373-376.
18. Hughson RL & Morrissey M (1982). Delayed kinetics of respiratory gas exchange in the transition from prior exercise. J Appl Physiol 52, 921-929.
19. Jones AM, Wilkerson DP & Fulford J (2008). Muscle [phosphocreatine] dynamics following the onset of exercise in humans: the influence of baseline work-rate. J Physiol 586, 889-898.
20. Kemp G (2008). Physiological implications of linear kinetics of mitochondrial respiration in vitro. Am J Physiol Cell Physiol 295, C844-C848.
21. Koga S, Poole DC, Shiojiri T, Kondo N, Fukuba Y, Miura A & Barstow TJ (2005). Comparison of oxygen uptake kinetics during knee extension and cycle exercise. Am J Physiol Regul Integr Comp Physiol 288, R212-R220.
22. 2 uptake kinetics during moderate- and high-intensity sub-maximal knee-extensor exercise in humans. J Physiol 587, 1843-1856.
23. Lamarra N (1990). Variables, constants, and parameters: clarifying the system structure. Med Sci Sports Exerc 22, 88-95.
24. Lamarra N, Whipp BJ, Ward SA & Wasserman K (1987). Effect of interbreath fluctuations on characterizing exercise gas exchange kinetics. J Appl Physiol 62, 2003-2012.
25. 2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain. J Appl Physiol 99, 1822-1834.
26. Meyer RA (1988). A linear model of muscle respiration explains monoexponential phosphocreatine changes. Am J Physiol Cell Physiol 254, C548-C553.
27. Meyer RA & Foley JM (1996). Cellular processes integrating the metabolic reponse to exercise. In Handbook of Physiology, section 12, Exercise: Regulation and Integration of Multiple systems, ed. Rowell LB & Shepherd JT, pp. 841-869. American Physiological Society, Bethesda, MD, USA.
28. Paterson ND, Kowalchuk JM & Paterson DH (2005). Effects of prior heavy-intensity exercise during single-leg knee extension on kinetics and limb blood flow. J Appl Physiol 99, 1462-1470.
29. Petrofsky JS (1979). Frequency and amplitude analysis of the EMG during exercise on the bicycle ergometer. Eur J Appl Physiol Occup Physiol 41, 1-15.
30. Rossiter HB (2011). Exercise: kinetics considerations. Comprehensive Physiology 1, 203-244.
31. 31P-magnetic resonance spectroscopy and parameter estimation of metabolic responses to exercise in humans. J Physiol 528, 359-369.
32. 2 uptake response to ramp incremental exercise. J Appl Physiol 100, 764-770.
33. 2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans. J Physiol 518, 921-932.
34. Rossiter HB, Ward SA, Kowalchuk JM, Howe FA, Griffiths JR & Whipp BJ (2001). Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans. J Physiol 537, 291-303.
35. Sargeant AJ & Dolan P (1987). Effect of prior exercise on maximal short-term power output in humans. J Appl Physiol 63, 1475-1480.
36. Shinohara M & Moritani T (1992). Increase in neuromuscular activity and oxygen uptake during heavy exercise. Ann Physiol Anthropol 11, 257-262.
37. 2 uptake and muscle deoxygenation kinetics are slowed in the upper compared to the lower region of the moderate-intensity exercise domain in older men. Eur J Appl Physiol; DOI:.
38. Suzuki S, Takasaki S, Ozaki T & Kobayashi Y (1999). A tissue oxygenation monitor using NIR spatially resolved spectroscopy. Proc SPIE 3597, 582-592.
39. Timmons JA, Poucher SM, Constantin-Teodosiu D, Worrall V, Macdonald IA & Greenhaff PL (1996). Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. J Clin Invest 97, 879-883.
40. Whipp BJ & Mahler M (1980). Dynamics of pulmonary gas exchange during exercise. In Pulmonary Gas Exchange, ed. West JB, pp. 33-96. Acedemic Press Inc., New York, NY, USA.
41. Whipp BJ, Ward SA, Lamarra N, Davis JA & Wasserman K (1982). Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 52, 1506-1513.
42. Whipp BJ, Ward SA & Wasserman K (1986). Respiratory markers of the anaerobic threshold. Adv Cardiol 35, 47-64.
43. 2 uptake on-kinetics during severe intensity exercise. Respir Physiol Neurobiol 152, 204-219.
44. 2 uptake on-kinetics during heavy-intensity exercise in humans. Respir Physiol Neurobiol 156, 203-211.