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Volumn 66, Issue 1, 2014, Pages 65-73

Antiviral activity of genital tract secretions after oral or topical tenofovir pre-exposure prophylaxis for HIV-1

Author keywords

HIV; HSV 2; mucosal immune mediators; pre exposure prophylaxis; tenofovir

Indexed keywords

DEFENSIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LACTOFERRIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PROTEIN; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; TENOFOVIR;

EID: 84898544900     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000110     Document Type: Article
Times cited : (22)

References (37)
  • 1
    • 84864505868 scopus 로고    scopus 로고
    • Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    • Baeten JM, Donnell D, Ndase P, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367: 399-410.
    • (2012) N Engl J Med , vol.367 , pp. 399-410
    • Baeten, J.M.1    Donnell, D.2    Ndase, P.3
  • 2
    • 84864527306 scopus 로고    scopus 로고
    • Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana
    • Thigpen MC, Kebaabetswe PM, Paxton LA, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med. 2012;367:423-434.
    • (2012) N Engl J Med , vol.367 , pp. 423-434
    • Thigpen, M.C.1    Kebaabetswe, P.M.2    Paxton, L.A.3
  • 3
    • 84878958898 scopus 로고    scopus 로고
    • Pre-exposure prophylaxis for HIV in women: Daily oral tenofovir, oral Tenofovir/Emtricitabine, or vaginal tenofovir gel in the VOICE study (MTN 003)
    • March 4 Atlanta, GA
    • Marrazzo JM, Ramjee G, Nair G, et al. Pre-exposure prophylaxis for HIV in women: daily oral tenofovir, oral Tenofovir/Emtricitabine, or vaginal tenofovir gel in the VOICE study (MTN 003). Paper presented at: 20th Conference on Retroviruses and Opportunistic Infections, March 4, 2013; Atlanta, GA.
    • (2013) 20th Conference on Retroviruses and Opportunistic Infections
    • Marrazzo, J.M.1    Ramjee, G.2    Nair, G.3
  • 4
    • 84864507852 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV infection among African women
    • Van Damme L, Corneli A, Ahmed K, et al. Preexposure prophylaxis for HIV infection among African women. N Engl J Med. 2012;367: 411-422.
    • (2012) N Engl J Med , vol.367 , pp. 411-422
    • Van Damme, L.1    Corneli, A.2    Ahmed, K.3
  • 5
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-1174.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3
  • 6
    • 84868474359 scopus 로고    scopus 로고
    • RMP-02/MTN-006: A phase 1 Rectal safety, Acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate
    • Anton PA, Cranston RD, Kashuba A, et al. RMP-02/MTN-006: a phase 1 Rectal safety, Acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate. AIDS Res Hum Retroviruses. 2012.
    • (2012) AIDS Res Hum Retroviruses
    • Anton, P.A.1    Cranston, R.D.2    Kashuba, A.3
  • 7
    • 28244467481 scopus 로고    scopus 로고
    • Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid
    • Venkataraman N, Cole AL, Svoboda P, et al. Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. J Immunol. 2005;175:7560-7567.
    • (2005) J Immunol , vol.175 , pp. 7560-7567
    • Venkataraman, N.1    Cole, A.L.2    Svoboda, P.3
  • 8
    • 79551565205 scopus 로고    scopus 로고
    • A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel
    • Keller MJ, Madan RP, Torres NM, et al. A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel. PLoS One. 2011; 6:e16475.
    • (2011) PLoS One , vol.6
    • Keller, M.J.1    Madan, R.P.2    Torres, N.M.3
  • 9
    • 27744561668 scopus 로고    scopus 로고
    • Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection
    • John M, Keller MJ, Fam EH, et al. Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. J Infect Dis. 2005; 192:1731-1740.
    • (2005) J Infect Dis , vol.192 , pp. 1731-1740
    • John, M.1    Keller, M.J.2    Fam, E.H.3
  • 10
    • 77956222058 scopus 로고    scopus 로고
    • Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies
    • Ghosh M, Fahey JV, Shen Z, et al. Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies. PLoS One. 2010;5:e11366.
    • (2010) PLoS One , vol.5
    • Ghosh, M.1    Fahey, J.V.2    Shen, Z.3
  • 11
    • 78651417113 scopus 로고    scopus 로고
    • Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection
    • Anderson PL, Kiser JJ, Gardner EM, et al. Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection. J Antimicrob Chemother. 2011;66:240-250.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 240-250
    • Anderson, P.L.1    Kiser, J.J.2    Gardner, E.M.3
  • 12
    • 84873858944 scopus 로고    scopus 로고
    • MTN-001: Randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments
    • Hendrix CW, Chen BA, Guddera V, et al. MTN-001: randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments. PLoS One. 2013; 8:e55013.
    • (2013) PLoS One , vol.8
    • Hendrix, C.W.1    Chen, B.A.2    Guddera, V.3
  • 13
    • 84870298088 scopus 로고    scopus 로고
    • Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation
    • Blish CA, McClelland RS, Richardson BA, et al. Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation. J Acquir Immune Defic Syndr. 2012;61: 436-440.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 436-440
    • Blish, C.A.1    McClelland, R.S.2    Richardson, B.A.3
  • 14
    • 84555189209 scopus 로고    scopus 로고
    • Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women
    • Roberts L, Passmore JA, Mlisana K, et al. Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women. J Infect Dis. 2012;205:194-203.
    • (2012) J Infect Dis , vol.205 , pp. 194-203
    • Roberts, L.1    Passmore, J.A.2    Mlisana, K.3
  • 15
    • 33750541721 scopus 로고    scopus 로고
    • Impact of microbicides and sexually transmitted infections on mucosal immunity in the female genital tract
    • Keller MJ, Herold BC. Impact of microbicides and sexually transmitted infections on mucosal immunity in the female genital tract. Am J Reprod Immunol. 2006;56:356-363.
    • (2006) Am J Reprod Immunol , vol.56 , pp. 356-363
    • Keller, M.J.1    Herold, B.C.2
  • 16
    • 0020665888 scopus 로고
    • Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations
    • Amsel R, Totten PA, Spiegel CA, et al. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. 1983; 74:14-22.
    • (1983) Am J Med , vol.74 , pp. 14-22
    • Amsel, R.1    Totten, P.A.2    Spiegel, C.A.3
  • 17
    • 33847018110 scopus 로고    scopus 로고
    • PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity
    • Keller MJ, Guzman E, Hazrati E, et al. PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity. AIDS. 2007;21:467-476.
    • (2007) AIDS , vol.21 , pp. 467-476
    • Keller, M.J.1    Guzman, E.2    Hazrati, E.3
  • 18
    • 84862678558 scopus 로고    scopus 로고
    • Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection
    • Mesquita PM, Rastogi R, Segarra TJ, et al. Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection. J Antimicrob Chemother. 2012.
    • (2012) J Antimicrob Chemother
    • Mesquita, P.M.1    Rastogi, R.2    Segarra, T.J.3
  • 19
    • 84866137168 scopus 로고    scopus 로고
    • Innate immune activation enhances HIV acquisition in women, Diminishing the effectiveness of tenofovir microbicide gel
    • Naranbhai V, Abdool Karim SS, AltfeldM, et al. Innate immune activation enhances HIV acquisition in women, Diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis. 2012;206:993-1001.
    • (2012) J Infect Dis , vol.206 , pp. 993-1001
    • Naranbhai, V.1    Abdool Karim, S.S.2    Altfeld, M.3
  • 20
    • 80054786208 scopus 로고    scopus 로고
    • A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel
    • Schwartz JL, Rountree W, Kashuba AD, et al. A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel. PLoS One. 2011;6:e25974.
    • (2011) PLoS One , vol.6
    • Schwartz, J.L.1    Rountree, W.2    Kashuba, A.D.3
  • 21
    • 84863622625 scopus 로고    scopus 로고
    • TGF-beta mediates proinflammatory seminal fluid Signaling in human cervical epithelial cells
    • Sharkey DJ, Macpherson AM, Tremellen KP, et al. TGF-beta mediates proinflammatory seminal fluid Signaling in human cervical epithelial cells. J Immunol. 2012;189:1024-1035.
    • (2012) J Immunol , vol.189 , pp. 1024-1035
    • Sharkey, D.J.1    Macpherson, A.M.2    Tremellen, K.P.3
  • 22
    • 34447320193 scopus 로고    scopus 로고
    • Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells
    • Sharkey DJ, Macpherson AM, Tremellen KP, et al. Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol Hum Reprod. 2007; 13:491-501.
    • (2007) Mol Hum Reprod , vol.13 , pp. 491-501
    • Sharkey, D.J.1    Macpherson, A.M.2    Tremellen, K.P.3
  • 23
    • 84857483300 scopus 로고    scopus 로고
    • Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus
    • Sharkey DJ, Tremellen KP, Jasper MJ, et al. Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus. J Immunol. 2012;188:2445-2454.
    • (2012) J Immunol , vol.188 , pp. 2445-2454
    • Sharkey, D.J.1    Tremellen, K.P.2    Jasper, M.J.3
  • 24
    • 84898538906 scopus 로고    scopus 로고
    • CAPRISA 004 Two Years on: Ten Key Lessons & Their Implications
    • April 15, 2012, Sydney, Australia
    • Karim SA. CAPRISA 004 Two Years on: Ten Key Lessons & Their Implications. Presented at Microbicides 2012, April 15, 2012; Sydney, Australia.
    • (2012) Microbicides
    • Karim, S.A.1
  • 25
    • 0031916651 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2- phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA
    • Robbins BL, Srinivas RV, Kim C, et al. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob Agents Chemother. 1998;42:612-617.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 612-617
    • Robbins, B.L.1    Srinivas, R.V.2    Kim, C.3
  • 26
    • 0037045009 scopus 로고    scopus 로고
    • Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells
    • Balzarini J, Van Herrewege Y, Vanham G. Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells. AIDS. 2002;16:2159-2163.
    • (2002) AIDS , vol.16 , pp. 2159-2163
    • Balzarini, J.1    Van Herrewege, Y.2    Vanham, G.3
  • 27
    • 0028300765 scopus 로고
    • Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 29,39-dideoxynucleoside analogs in resting and activated human cells
    • Gao WY, Agbaria R, Driscoll JS, et al. Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 29,39-dideoxynucleoside analogs in resting and activated human cells. J Biol Chem. 1994;269: 12633-12638.
    • (1994) J Biol Chem , vol.269 , pp. 12633-12638
    • Gao, W.Y.1    Agbaria, R.2    Driscoll, J.S.3
  • 28
    • 80052070000 scopus 로고    scopus 로고
    • Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors
    • Garcia-Lerma JG, Aung W, Cong ME, et al. Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors. J Virol. 2011;85:6610-6617.
    • (2011) J Virol , vol.85 , pp. 6610-6617
    • Garcia-Lerma, J.G.1    Aung, W.2    Cong, M.E.3
  • 29
    • 0034852408 scopus 로고    scopus 로고
    • Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs
    • Cihlar T, Ho ES, Lin DC, et al. Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids. 2001;20:641-648.
    • (2001) Nucleosides Nucleotides Nucleic Acids , vol.20 , pp. 641-648
    • Cihlar, T.1    Ho, E.S.2    Lin, D.C.3
  • 30
    • 78650915162 scopus 로고    scopus 로고
    • No impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in HIV-infected adults
    • Tan DH, Kaul R, Raboud JM, et al. No impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in HIV-infected adults. AIDS. 2011;25:207-210.
    • (2011) AIDS , vol.25 , pp. 207-210
    • Tan, D.H.1    Kaul, R.2    Raboud, J.M.3
  • 31
    • 84866994975 scopus 로고    scopus 로고
    • Changes in the soluble mucosal immune environment during genital herpes outbreaks
    • Keller MJ, Madan RP, Shust G, et al. Changes in the soluble mucosal immune environment during genital herpes outbreaks. J Acquir Immune Defic Syndr. 2012;61:194-202.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 194-202
    • Keller, M.J.1    Madan, R.P.2    Shust, G.3
  • 32
    • 73949143582 scopus 로고    scopus 로고
    • Female genital tract secretions inhibit herpes simplex virus infection: Correlation with soluble mucosal immune mediators and impact of hormonal contraception
    • Shust GF, Cho S, Kim M, et al. Female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception. Am J Reprod Immunol. 2010;63:110-119.
    • (2010) Am J Reprod Immunol , vol.63 , pp. 110-119
    • Shust, G.F.1    Cho, S.2    Kim, M.3
  • 33
    • 84863713414 scopus 로고    scopus 로고
    • Altered biomarkers of mucosal immunity and reduced vaginal Lactobacillus concentrations in sexually active female adolescents
    • Madan RP, Carpenter C, Fiedler T, et al. Altered biomarkers of mucosal immunity and reduced vaginal Lactobacillus concentrations in sexually active female adolescents. PLoS One. 2012;7:e40415.
    • (2012) PLoS One , vol.7
    • Madan, R.P.1    Carpenter, C.2    Fiedler, T.3
  • 34
    • 84864385142 scopus 로고    scopus 로고
    • Reformulated tenofovir gel for use as a dual compartment microbicide
    • Dezzutti CS, Rohan LC, Wang L, et al. Reformulated tenofovir gel for use as a dual compartment microbicide. J Antimicrob Chemother. 2012; 67:2139-2142.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 2139-2142
    • Dezzutti, C.S.1    Rohan, L.C.2    Wang, L.3
  • 35
    • 77949532283 scopus 로고    scopus 로고
    • In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As An HIV-1 Microbicide
    • Rohan LC, Moncla BJ, Kunjara Na Ayudhya RP, et al. In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide. PLoS One. 2010;5:e9310.
    • (2010) PLoS One , vol.5
    • Rohan, L.C.1    Moncla, B.J.2    Kunjara Na Ayudhya, R.P.3
  • 36
    • 73949111462 scopus 로고    scopus 로고
    • Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: A continuum or distinct underlying mechanisms?
    • Maagaard A, Kvale D. Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms? J Antimicrob Chemother. 2009;64: 901-909.
    • (2009) J Antimicrob Chemother , vol.64 , pp. 901-909
    • Maagaard, A.1    Kvale, D.2
  • 37


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