Altered biomarkers of mucosal immunity and reduced vaginal lactobacillus concentrations in sexually active female adolescents

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Madan, Rebecca Pellett ^a   Carpenter, Colleen ^a   Fiedler, Tina ^b   Kalyoussef, Sabah ^a   McAndrew, Thomas C ^a   Viswanathan, Shankar ^a   Kim, Mimi ^a   Keller, Marla J ^a   Fredricks, David N ^b   Herold, Betsy C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTERFERON; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES;

ADOLESCENT; ADULT; ANTIMICROBIAL ACTIVITY; ARTICLE; ESCHERICHIA COLI; FEMALE; HUMAN; LACTOBACILLUS; LACTOBACILLUS CRISPATUS; LACTOBACILLUS JENSENII; MUCOSAL IMMUNITY; NONHUMAN; POLYMERASE CHAIN REACTION; PREMENOPAUSE; SEXUAL BEHAVIOR; VAGINA FLORA; VAGINAL LAVAGE;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; BIOLOGICAL MARKERS; CHEMOKINES; ESCHERICHIA COLI; FEMALE; HUMANS; IMMUNITY, MUCOSAL; LACTOBACILLUS; LINEAR MODELS; MULTIVARIATE ANALYSIS; POLYMERASE CHAIN REACTION; SEXUAL BEHAVIOR; SIMPLEXVIRUS; SOLUBILITY; STATISTICS, NONPARAMETRIC; VAGINA; VAGINAL DOUCHING;

ESCHERICHIA COLI; LACTOBACILLUS; LACTOBACILLUS CRISPATUS; LACTOBACILLUS JENSENII; SIMPLEXVIRUS;

EID: 84863713414     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040415     Document Type: Article

References (44)

1. Geisler WM, (2011) Diagnosis and management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: summary of evidence reviewed for the 2010 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. Clin Infect Dis 53: S92-98.
2. Workowski KA, Berman S, (2010) Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 59: 1-110.
3. Moss GB, Clemetson D, D'Costa L, Plummer FA, Ndinya-Achola JO, et al. (1991) Association of cervical ectopy with heterosexual transmission of human immunodeficiency virus: results of a study of couples in Nairobi, Kenya. J Infect Dis 164: 588-591.
4. Mansfield MJ, Emans SJ, (1984) Adolescent menstrual irregularity. J Reprod Med 29: 399-410.
5. (1986) World Health Organization multicenter study on menstrual and ovulatory patterns in adolescent girls. I. A multicenter cross-sectional study of menarche. World Health Organization Task Force on Adolescent Reproductive Health. J Adolesc Health Care 7: 229-235.
6. Hwang LY, Scott ME, Ma Y, Moscicki AB, (2011) Higher levels of cervicovaginal inflammatory and regulatory cytokines and chemokines in healthy young women with immature cervical epithelium. J Reprod Immunol 88: 66-71.
7. Levinson P, Kaul R, Kimani J, Ngugi E, Moses S, et al. (2009) Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. AIDS 23: 309-317.
8. Marrazzo JM, (2006) A persistent(ly) enigmatic ecological mystery: bacterial vaginosis. J Infect Dis 193: 1475-1477.
9. John M, Keller MJ, Fam EH, Cheshenko N, Hogarty K, et al. (2005) Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. J Infect Dis 192: 1731-1740.
10. Shust GF, Cho S, Kim M, Madan RP, Guzman EM, et al. (2010) Female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception. Am J Reprod Immunol 63: 110-119.
11. Keller MJ, Guzman E, Hazrati E, Kasowitz A, Cheshenko N, et al. (2007) PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity. AIDS 21: 467-476.
12. Valore EV, Wiley DJ, Ganz T, (2006) Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun 74: 5693-5702.
13. Matu MN, Orinda GO, Njagi EN, Cohen CR, Bukusi EA, (2010) In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women. Anaerobe 16: 210-215.
14. Graver MA, Wade JJ, (2011) The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth. Ann Clin Microbiol Antimicrob 10: 8.
15. Aroutcheva A, Gariti D, Simon M, Shott S, Faro J, et al. (2001) Defense factors of vaginal lactobacilli. Am J Obstet Gynecol 185: 375-379.
16. Feierman J, Lieberman D, Schissel A, Diller R, Kim J, Chu Y for the New York Civil Liberties Union Reproductive Rights Project (2002) Teenagers, health care, and the law: A guide to the law on minors' rights in New York State. Available: http://www.nyclu.org/files/thl.pdf. Accessed: 2012 March 13.
17. Keller MJ, Madan RP, Torres NM, Fazzari MJ, Cho S, et al. (2011) A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel. PLoS One 6: e16475.
18. Fredricks DN, Fiedler TL, Thomas KK, Mitchell CM, Marrazzo JM, (2009) Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. J Clin Microbiol 47: 721-726.
19. Khot PD, Ko DL, Hackman RC, Fredricks DN, (2008) Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. BMC Infect Dis 8: 73.
20. Fredricks DN, Fiedler TL, Thomas KK, Oakley BB, Marrazzo JM, (2007) Targeted PCR for detection of vaginal bacteria associated with bacterial vaginosis. J Clin Microbiol 45: 3270-3276.
21. Marrazzo JM, (2011) Interpreting the epidemiology and natural history of bacterial vaginosis: are we still confused? Anaerobe 17: 186-190.
22. Fredricks DN, (2011) Molecular methods to describe the spectrum and dynamics of the vaginal microbiota. Anaerobe 17: 191-195.
23. Cremel M, Hamzeh-Cognasse H, Genin C, Delezay O, (2006) Female genital tract immunization: evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation. Vaccine 24: 5744-5754.
24. Cole AM, (2006) Innate host defense of human vaginal and cervical mucosae. Curr Top Microbiol Immunol 306: 199-230.
25. Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, et al. (2004) Activity of alpha- and theta-defensins against primary isolates of HIV-1. J Immunol 173: 515-520.
26. Hazrati E, Galen B, Lu W, Wang W, Ouyang Y, et al. (2006) Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection. J Immunol 177: 8658-8666.
27. Saidi H, Eslahpazir J, Carbonneil C, Carthagena L, Requena M, et al. (2006) Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies. J Immunol 177: 5540-5549.
28. Valimaa H, Tenovuo J, Waris M, Hukkanen V, (2009) Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread. Virol J 6: 53.
29. Lee-Huang S, Huang PL, Sun Y, Huang PL, Kung HF, et al. (1999) Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin. Proc Natl Acad Sci U S A 96: 2678-2681.
30. Lee-Huang S, Maiorov V, Huang PL, Ng A, Lee HC, et al. (2005) Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity. Biochemistry 44: 4648-4655.
31. Draper DL, Landers DV, Krohn MA, Hillier SL, Wiesenfeld HC, et al. (2000) Levels of vaginal secretory leukocyte protease inhibitor are decreased in women with lower reproductive tract infections. Am J Obstet Gynecol 183: 1243-1248.
32. Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, et al. (2011) Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding. J Infect Dis 204: 1550-1556.
33. Roberts L, Passmore JA, Mlisana K, Williamson C, Little F, et al. (2012) Genital Tract Inflammation During Early HIV-1 Infection Predicts Higher Plasma Viral Load Set Point in Women. J Infect Dis 205: 194-203.
34. Shrier LA, Bowman FP, Lin M, Crowley-Nowick PA, (2003) Mucosal immunity of the adolescent female genital tract. J Adolesc Health 32: 183-186.
35. McComb DE, Nichols RL, Semine DZ, Evrard JR, Alpert S, et al. (1979) Chlamydia trachomatis in women: antibody in cervical secretions as a possible indicator of genital infection. J Infect Dis 139: 628-633.
36. Tuffrey M, Alexander F, Taylor-Robinson D, (1990) Severity of salpingitis in mice after primary and repeated inoculation with a human strain of Chlamydia trachomatis. J Exp Pathol (Oxford) 71: 403-410.
37. Wolner-Hanssen P, Patton DL, Holmes KK, (1991) Protective immunity in pig-tailed macaques after cervical infection with Chlamydia trachomatis. Sex Transm Dis 18: 21-25.
38. Rank RG, Whittum-Hudson JA, (2010) Protective immunity to chlamydial genital infection: evidence from animal studies. J Infect Dis 201: S168-177.
39. Batteiger BE, Tu W, Ofner S, van Der Pol B, Stothard DR, et al. (2010) Repeated Chlamydia trachomatis genital infections in adolescent women. J Infect Dis 201: 42-51.
40. Marrazzo JM, Thomas KK, Fiedler TL, Ringwood K, Fredricks DN, (2008) Relationship of specific vaginal bacteria and bacterial vaginosis treatment failure in women who have sex with women. Ann Intern Med 149: 20-28.
41. Mitchell CM, Balkus J, Agnew KJ, Cohn S, Luque A, et al. (2008) Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines. AIDS Res Hum Retroviruses 24: 667-671.
42. Atashili J, Poole C, Ndumbe PM, Adimora AA, Smith JS, (2008) Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS 22: 1493-1501.
43. Rebbapragada A, Howe K, Wachihi C, Pettengell C, Sunderji S, et al. (2008) Bacterial vaginosis in HIV-infected women induces reversible alterations in the cervical immune environment. J Acquir Immune Defic Syndr 49: 520-522.
44. Cu-Uvin S, Hogan JW, Caliendo AM, Harwell J, Mayer KH, et al. (2001) Association between bacterial vaginosis and expression of human immunodeficiency virus type 1 RNA in the female genital tract. Clin Infect Dis 33: 894-896.