-
1
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou TC (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58: 621-681.
-
(2006)
Pharmacol Rev
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
-
2
-
-
77950831001
-
Cancer therapy reform
-
Levinson AD (2010) Cancer therapy reform. Science 328: 137.
-
(2010)
Science
, vol.328
, pp. 137
-
-
Levinson, A.D.1
-
3
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics
-
DOI 10.1073/pnas.1337088100
-
Borisy AA, Elliott PJ, Hurst NW, Lee MS, Lehar J, et al. (2003) Systematic discovery of multicomponent therapeutics. Proc Natl Acad Sci U S A 100: 7977-7982. (Pubitemid 36760080)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.13
, pp. 7977-7982
-
-
Borisy, A.A.1
Elliott, P.J.2
Hurst, N.W.3
Lee, M.S.4
Lehar, J.5
Price, E.R.6
Serbedzija, G.7
Zimmermann, G.R.8
Foley, M.A.9
Stockwellt, B.R.10
Keith, C.T.11
-
4
-
-
33845762340
-
Multi-target therapeutics: When the whole is greater than the sum of the parts
-
DOI 10.1016/j.drudis.2006.11.008, PII S1359644606004697
-
Zimmermann GR, Lehar J, Keith CT (2007) Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 12: 34-42. (Pubitemid 46014485)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.1-2
, pp. 34-42
-
-
Zimmermann, G.R.1
Lehar, J.2
Keith, C.T.3
-
5
-
-
76149110146
-
Synergy: An old wisdom, a new paradigm for pharmacotherapy
-
Biavatti MW (2009) Synergy: an old wisdom, a new paradigm for pharmacotherapy. Brazilian Journal of Pharmaceutical Sciences 45: 371-378.
-
(2009)
Brazilian Journal of Pharmaceutical Sciences
, vol.45
, pp. 371-378
-
-
Biavatti, M.W.1
-
6
-
-
33747620519
-
Systems biology and combination therapy in the quest for clinical efficacy
-
DOI 10.1038/nchembio817, PII NCHEMBIO817
-
Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK (2006) Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol 2: 458-466. (Pubitemid 44266307)
-
(2006)
Nature Chemical Biology
, vol.2
, Issue.9
, pp. 458-466
-
-
Fitzgerald, J.B.1
Schoeberl, B.2
Nielsen, U.B.3
Sorger, P.K.4
-
7
-
-
10944272743
-
Antibacterial resistance worldwide: Causes, challenges and responses
-
DOI 10.1038/nm1145
-
Levy SB, Marshall B (2004) Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 10: S122-129. (Pubitemid 40018235)
-
(2004)
Nature Medicine
, vol.10
, Issue.12 SUPPL.
-
-
Levy, S.B.1
Marshall, B.2
-
8
-
-
84946384873
-
The toxicity of poisons applied jointly
-
Bliss CI (1939) The toxicity of poisons applied jointly. Annals of Applied Biology 26: 585-615.
-
(1939)
Annals of Applied Biology
, vol.26
, pp. 585-615
-
-
Bliss, C.I.1
-
9
-
-
0035830860
-
Principles for the buffering of genetic variation
-
Hartman JLt, Garvik B, Hartwell L (2001) Principles for the buffering of genetic variation. Science 291: 1001-1004.
-
(2001)
Science
, vol.291
, pp. 1001-1004
-
-
Hartman, J.Lt.1
Garvik, B.2
Hartwell, L.3
-
10
-
-
0001663843
-
The problem of synergism and antagonism of combined drugs
-
Loewe S (1953) The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3: 285-290.
-
(1953)
Arzneimittelforschung
, vol.3
, pp. 285-290
-
-
Loewe, S.1
-
11
-
-
27744536258
-
Synergism, antagonism, or additivity of dietary supplements: Application of theory to case studies
-
discussion 145-151
-
Borgert CJ, Borgert SA, Findley KC (2005) Synergism, antagonism, or additivity of dietary supplements: application of theory to case studies. Thromb Res 117: 123-132; discussion 145-151.
-
(2005)
Thromb Res
, vol.117
, pp. 123-132
-
-
Borgert, C.J.1
Borgert, S.A.2
Findley, K.C.3
-
12
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco WR, Bravo G, Parsons JC (1995) The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 47: 331-385.
-
(1995)
Pharmacol Rev
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
13
-
-
77049158324
-
Antibiotic synergism and antagonism; an assessment of the problem
-
Jawetz E, Gunnison JB (1953) Antibiotic synergism and antagonism; an assessment of the problem. Pharmacol Rev 5: 175-192.
-
(1953)
Pharmacol Rev
, vol.5
, pp. 175-192
-
-
Jawetz, E.1
Gunnison, J.B.2
-
16
-
-
57049155922
-
Preclinical versus clinical drug combination studies
-
Chou TC (2008) Preclinical versus clinical drug combination studies. Leuk Lymphoma 49: 2059-2080.
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 2059-2080
-
-
Chou, T.C.1
-
17
-
-
37049002657
-
The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action
-
DOI 10.1158/0008-5472.CAN-07-2235
-
Lee MS, Johansen L, Zhang YZ, Wilson A, Keegan M, et al. (2007) The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action. Cancer Res 67: 11359-11367. (Pubitemid 350248563)
-
(2007)
Cancer Research
, vol.67
, Issue.23
, pp. 11359-11367
-
-
Lee, M.S.1
Johansen, L.2
Zhang, Y.3
Wilson, A.4
Keegan, M.5
Avery, W.6
Elliott, P.7
Borisy, A.A.8
Keith, C.T.9
-
18
-
-
78649893706
-
Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy
-
Biran A, Brownstein M, Haklai R, Kloog Y (2011) Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. Int J Cancer 128: 691-701.
-
(2011)
Int J Cancer
, vol.128
, pp. 691-701
-
-
Biran, A.1
Brownstein, M.2
Haklai, R.3
Kloog, Y.4
-
19
-
-
77954978118
-
NECT is next: Implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness
-
Yun O, Priotto G, Tong J, Flevaud L, Chappuis F (2010) NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness. PLoS Negl Trop Dis 4: e720.
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Yun, O.1
Priotto, G.2
Tong, J.3
Flevaud, L.4
Chappuis, F.5
-
20
-
-
77949639846
-
Triple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro
-
Nguyen JT, Hoopes JD, Le MH, Smee DF, Patick AK, et al. (2010) Triple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro. PLoS One 5.
-
(2010)
PLoS One
, vol.5
-
-
Nguyen, J.T.1
Hoopes, J.D.2
Le, M.H.3
Smee, D.F.4
Patick, A.K.5
-
21
-
-
77953552589
-
Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells
-
Cusimano A, Azzolina A, Iovanna JL, Bachvarov D, McCubrey JA, et al. (2010) Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells. Cell Cycle 9: 1399-1410.
-
(2010)
Cell Cycle
, vol.9
, pp. 1399-1410
-
-
Cusimano, A.1
Azzolina, A.2
Iovanna, J.L.3
Bachvarov, D.4
McCubrey, J.A.5
-
22
-
-
80051787355
-
Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist
-
Parameswaran R, Yu M, Lim M, Groffen J, Heisterkamp N (2011) Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist. Leukemia 25: 1314-1323.
-
(2011)
Leukemia
, vol.25
, pp. 1314-1323
-
-
Parameswaran, R.1
Yu, M.2
Lim, M.3
Groffen, J.4
Heisterkamp, N.5
-
23
-
-
77955101158
-
The Combination of a Histone Deacetylase Inhibitor with the Bcl-2 Homology Domain-3 Mimetic GX15-070 Has Synergistic Antileukemia Activity by Activating Both Apoptosis and Autophagy
-
Wei Y, Kadia T, Tong WG, Zhang M, Jia Y, et al. (2010) The Combination of a Histone Deacetylase Inhibitor with the Bcl-2 Homology Domain-3 Mimetic GX15-070 Has Synergistic Antileukemia Activity by Activating Both Apoptosis and Autophagy. Clinical Cancer Research 16: 3923-3932.
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 3923-3932
-
-
Wei, Y.1
Kadia, T.2
Tong, W.G.3
Zhang, M.4
Jia, Y.5
-
24
-
-
79551698205
-
A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer
-
Kelly RJ, Draper D, Chen CC, Robey RW, Figg WD, et al. (2011) A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer. Clin Cancer Res 17: 569-580.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 569-580
-
-
Kelly, R.J.1
Draper, D.2
Chen, C.C.3
Robey, R.W.4
Figg, W.D.5
-
25
-
-
84872730960
-
Combination Drug Therapy for Pain following Chronic Spinal Cord Injury
-
Hama A, Sagen J (2012) Combination Drug Therapy for Pain following Chronic Spinal Cord Injury. Pain Research and Treatment 2012.
-
(2012)
Pain Research and Treatment 2012
-
-
Hama, A.1
Sagen, J.2
-
26
-
-
73849123558
-
Interactions between traditional Chinese medicines and Western therapeutics
-
Chan E, Tan M, Xin JN, Sudarsanam S, Johnson DE (2010) Interactions between traditional Chinese medicines and Western therapeutics. Current Opinion in Drug Discovery Development 13: 50-65.
-
(2010)
Current Opinion in Drug Discovery Development
, vol.13
, pp. 50-65
-
-
Chan, E.1
Tan, M.2
Xin, J.N.3
Sudarsanam, S.4
Johnson, D.E.5
-
27
-
-
33845618105
-
Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation
-
DOI 10.1038/sj.bjp.0706945, PII 0706945
-
Chen X, Zhou H, Liu YB, Wang JF, Li H, et al. (2006) Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation. Br J Pharmacol 149: 1092-1103. (Pubitemid 44950812)
-
(2006)
British Journal of Pharmacology
, vol.149
, Issue.8
, pp. 1092-1103
-
-
Chen, X.1
Zhou, H.2
Liu, Y.B.3
Wang, J.F.4
Li, H.5
Ung, C.Y.6
Han, L.Y.7
Cao, Z.W.8
Chen, Y.Z.9
-
28
-
-
54349085371
-
Chinese medicine and biomodulation in cancer patients - Part one
-
Sagar SM, Wong RK (2008) Chinese medicine and biomodulation in cancer patients - Part one. Curr Oncol 15: 42-48.
-
(2008)
Curr Oncol
, vol.15
, pp. 42-48
-
-
Sagar, S.M.1
Wong, R.K.2
-
30
-
-
33750069402
-
Advances in chemotherapy of non-small cell lung cancer
-
DOI 10.1378/chest.130.4.1211
-
Molina JR, Adjei AA, Jett JR (2006) Advances in chemotherapy of non-small cell lung cancer. Chest 130: 1211-1219. (Pubitemid 44583755)
-
(2006)
Chest
, vol.130
, Issue.4
, pp. 1211-1219
-
-
Molina, J.R.1
Adjei, A.A.2
Jett, J.R.3
-
31
-
-
33646691223
-
New developments in chemotherapy for advanced non-small cell lung cancer
-
DOI 10.1097/01.cco.0000208789.37689.6b, PII 0000162220060300000010
-
Raez LE, Lilenbaum R (2006) New developments in chemotherapy for advanced non-small cell lung cancer. Curr Opin Oncol 18: 156-161. (Pubitemid 43740436)
-
(2006)
Current Opinion in Oncology
, vol.18
, Issue.2
, pp. 156-161
-
-
Raez, L.E.1
Lilenbaum, R.2
-
32
-
-
33947285105
-
Docetaxel/anthracycline combinations for breast cancer treatment
-
von Minckwitz G (2007) Docetaxel/anthracycline combinations for breast cancer treatment. Expert Opin Pharmacother 8: 485-495.
-
(2007)
Expert Opin Pharmacother
, vol.8
, pp. 485-495
-
-
Von Minckwitz, G.1
-
34
-
-
67650488269
-
Synergistic drug combinations tend to improve therapeutically relevant selectivity
-
Lehar J, Krueger AS, Avery W, Heilbut AM, Johansen LM, et al. (2009) Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nature Biotechnology 27: 659-666.
-
(2009)
Nature Biotechnology
, vol.27
, pp. 659-666
-
-
Lehar, J.1
Krueger, A.S.2
Avery, W.3
Heilbut, A.M.4
Johansen, L.M.5
-
35
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
DOI 10.1021/np068054v
-
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. Journal of natural products 70: 461-477. (Pubitemid 46595760)
-
(2007)
Journal of Natural Products
, vol.70
, Issue.3
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
36
-
-
34248361999
-
High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections
-
DOI 10.1073/pnas.0609370104
-
Zhang LX, Yan KZ, Zhang Y, Huang R, Bian J, et al. (2007) High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc Natl Acad Sci U S A 104: 4606-4611. (Pubitemid 47186272)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.11
, pp. 4606-4611
-
-
Zhang, L.1
Yan, K.2
Zhang, Y.3
Huang, R.4
Bian, J.5
Zheng, C.6
Sun, H.7
Chen, Z.8
Sun, N.9
An, R.10
Min, F.11
Zhao, W.12
Zhuo, Y.13
You, J.14
Song, Y.15
Yu, Z.16
Liu, Z.17
Yang, K.18
Gao, H.19
Dai, H.20
Zhang, X.21
Wang, J.22
Fu, C.23
Pei, G.24
Liu, J.25
Zhang, S.26
Goodfellow, M.27
Jiang, Y.28
Kuai, J.29
Zhou, G.30
Chen, X.31
more..
-
37
-
-
38549151817
-
DrugBank: A knowledgebase for drugs, drug actions and drug targets
-
DOI 10.1093/nar/gkm958
-
Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, et al. (2008) DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 36: D901-906. (Pubitemid 351149842)
-
(2008)
Nucleic Acids Research
, vol.36
, Issue.SUPPL. 1
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Cheng, D.4
Shrivastava, S.5
Tzur, D.6
Gautam, B.7
Hassanali, M.8
-
38
-
-
33644874819
-
From genomics to chemical genomics: New developments in KEGG
-
Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, et al. (2006) From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res 34: D354-357.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Kanehisa, M.1
Goto, S.2
Hattori, M.3
Aoki-Kinoshita, K.F.4
Itoh, M.5
-
39
-
-
38549182474
-
SuperTarget and Matador: Resources for exploring drug-target relationships
-
DOI 10.1093/nar/gkm862
-
Gunther S, Kuhn M, Dunkel M, Campillos M, Senger C, et al. (2008) SuperTarget and Matador: resources for exploring drug-target relationships. Nucleic Acids Res 36: D919-922. (Pubitemid 351149845)
-
(2008)
Nucleic Acids Research
, vol.36
, Issue.SUPPL. 1
-
-
Gunther, S.1
Kuhn, M.2
Dunkel, M.3
Campillos, M.4
Senger, C.5
Petsalaki, E.6
Ahmed, J.7
Urdiales, E.G.8
Gewiess, A.9
Jensen, L.J.10
Schneider, R.11
Skoblo, R.12
Russell, R.B.13
Bourne, P.E.14
Bork, P.15
Preissner, R.16
-
40
-
-
0018663921
-
A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptococcal meningitis
-
Bennett JE, Dismukes WE, Duma RJ, Medoff G, Sande MA, et al. (1979) A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptoccal meningitis. New England Journal of Medicine 301: 126-131. (Pubitemid 10225854)
-
(1979)
New England Journal of Medicine
, vol.301
, Issue.3
, pp. 126-131
-
-
Bennett, J.E.1
Dismukes, W.E.2
Duma, R.J.3
-
41
-
-
12844258859
-
Combination treatment of invasive fungal infections
-
DOI 10.1128/CMR.18.1.163-194.2005
-
Mukherjee PK, Sheehan DJ, Hitchcock CA, Ghannoum MA (2005) Combination treatment of invasive fungal infections. Clinical microbiology reviews 18: 163-194. (Pubitemid 40170667)
-
(2005)
Clinical Microbiology Reviews
, vol.18
, Issue.1
, pp. 163-194
-
-
Mukherjee, P.K.1
Sheehan, D.J.2
Hitchcock, C.A.3
Ghannoum, M.A.4
-
43
-
-
70449412365
-
Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: Endogenous ROS augmentation
-
Xu Y, Wang Y, Yan L, Liang RM, Dai BD, et al. (2009) Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: endogenous ROS augmentation. J Proteome Res 8: 5296-5304.
-
(2009)
J Proteome Res
, vol.8
, pp. 5296-5304
-
-
Xu, Y.1
Wang, Y.2
Yan, L.3
Liang, R.M.4
Dai, B.D.5
|