Study of complement activation, C3 and interleukin-6 levels in burn patients and their role as prognostic markers

Indian Journal of Medical Microbiology

Volumn 32, Issue 2, 2014, Pages 137-142

  Modi, S ^a   Rashid, M ^b   Malik, A ^c   Shahid, M ^c  

^a Dr B C Roy Hospital   (India)

^b SHARDA UNIVERSITY   (India)

^c ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

C3; Complement activation; crossed electrophoresis; interleukin 6; single radial immunodiffusion

Indexed keywords

ANTISERUM; COMPLEMENT COMPONENT C3; INTERLEUKIN 6; BIOLOGICAL MARKER;

ADULT; AGAR GEL ELECTROPHORESIS; AGED; ARTICLE; BACTERIAL INFECTION; BACTERIUM ISOLATE; BLOOD CULTURE; BODY SURFACE; BURN INFECTION; BURN PATIENT; COMPLEMENT ACTIVATION; CONTROLLED STUDY; COUNTER IMMUNOELECTROPHORESIS; CROSSED ELECTROPHORESIS; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROPHORESIS; ELISA KIT; ENTEROCOCCUS FAECALIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMAN; IMMUNODIFFUSION; INJURY SEVERITY; MAJOR CLINICAL STUDY; MORTALITY; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PROGNOSIS; PSEUDOMONAS; SEPTICEMIA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; SURVIVOR; BLOOD; BURN; FEMALE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BURNS; COMPLEMENT ACTIVATION; COMPLEMENT C3; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; PROGNOSIS;

EID: 84898476895     PISSN: 02550857     EISSN: 19983646     Source Type: Journal    
DOI: 10.4103/0255-0857.129793     Document Type: Article

References (28)

1. Hietbrink F, Koenderman L, Rijkers G, Leenen L. Trauma: The role of the innate immune system. World J Emerg Surg 2006;1:15.
2. Sharma DK, Sarda AK, Bhalla SA, Goyal A, Kulshreshta VN. The effect of recent trauma on serum complement activation and serum C3 levels correlated with the injury severity score. Indian J Med Microbiol 2004;22:147-52.
3. Kang HJ, Kim JH, Lee EH, Lee YK, Hur M, Lee KM. Change of complement system predicts the outcome of patients with severe thermal injury. J Burn Care Rehabil 2003;24:148-53.
4. Huber-Lang MS, Younkin EM, Sarma JV, McGuire SR, Lu KT, Guo RF, et al. Complement-induced impairment of innate immunity during sepsis. J Immunol 2002;169:3223-31.
5. Catania RA, Chaudry IH. Immunological consequences of trauma and shock. Ann Acad Med Singapore 1999;28:120-32.
6. Hecke F, Schmidt U, Kola A, Bautsch W, Klos A, Köhl J. Circulating complement proteins in multiple trauma patients - Correlation with injury severity, development of sepsis, and outcome. Crit Care Med 1997;25:2015-24.
7. Heideman M, Kaijser B, Gelin LE. Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury. J Trauma 1978;18:696-700.
8. Peakman M, Senaldi G, Vergani D. Review: Assessment of complement activation in clinical immunology laboratories: Time for reappraisal? J Clin Pathol 1989;42:1018-25.
9. Heideman M, Saravis C, Clowes GH Jr. Effect of nonviable tissue and abscesses on complement depletion and the development of bacteremia. J Trauma 1982;22:527-32.
10. Bjornson AB, Altemeier WA, Bjornson HS. Reduction in C3 conversion in patients with severe thermal injury. J Trauma 1976;16:905-11.
11. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 1997;25:1813-9.
12. Fey GH, Gauldie J. The acute phase response of liver in inflammation. In: Popper H, Schaffner F, editors. Progress in Liver Disease. Philadelphia: WB Saunders; 1990. p. 89.
13. Coleman DJ. Assessment of the burn area. In: Russel RC, Williams NS, Bulstrode CJ, editors. Bailey and Love's Short Practice of Surgery. UK: Arnold Publishers; 2004. p. 188-9.
14. Rojas-Espinosa O, Estrada-Parra S, Serrano-Miranda E, Saul A, Latapi F. Antimycobacterial antibodies in diffuse lepromatous leprosy detected by counterimmunoelectrophoresis. Int J Lepr Other Mycobact Dis 1976;44:448-52.
15. Laurell CB. Antigen-antibody crossed electrophoresis. Anal Biochem 1965;10:358-61.
16. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965;2:235-54.
17. Fischer MB, Prodeus AP, Nicholson-Weller A, Ma M, Murrow J, Reid RR, et al. Increased susceptibility to endotoxin shock in complement C3-and C4-deficient mice is corrected by C1 inhibitor replacement. J Immunol 1997;159:976-82.
18. Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, et al. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci U S A 2002;99:16969-74.
19. Younger JG, Sasaki N, Waite MD, Murray HN, Saleh EF, Ravage ZB, et al. Detrimental effects of complement activation in hemorrhagic shock. J Appl Physiol (1985) 2001;90:441-6.
20. Weiser MR, Williams JP, Moore FD Jr, Kobzik L, Ma M, Hechtman HB, et al. Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J Exp Med 1996;183:2343-8.
21. Nast-Kolb D, Waydhas C, Gippner-Steppert C, Schneider I, Trupka A, Ruchholtz S, et al. Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma 1997;42:446-54.
22. Kowal-Vern A, Walenga JM, Hoppensteadt D, Sharp-Pucci M, Gamelli RL. Interleukin-2 and interleukin-6 in relation to burn wound size in the acute phase of thermal injury. J Am Coll Surg 1994;178:357-62.
23. Nijsten MW, Hack CE, Helle M, ten Duis HJ, Klasen HJ, Aarden LA. Interleukin-6 and its relation to the humoral immune response and clinical parameters in burned patients. Surgery 1991;109:761-7.
24. Gaïni S, Koldkjaer OG, Pedersen C, Pedersen SS. Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: A prospective study. Crit Care 2006;10:R53.
25. Selberg O, Hecker H, Martin M, Klos A, Bautsch W, Köhl J. Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6. Crit Care Med 2000;28:2793-8.
26. Biffl WL, Moore EE, Moore FA, Peterson VM. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg 1996;224:647-64.
27. Gebhard F, Pfetsch H, Steinbach G, Strecker W, Kinzl L, Brückner UB. Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg 2000;135:291-5.
28. Yagmur Y, Ozturk H, Unaldi M, Gedik E. Relation between severity of injury and the early activation of interleukins in multiple-injured patients. Eur Surg Res 2005;37:360-4.