메뉴 건너뛰기




Volumn 25, Issue 4, 2014, Pages 530-542

Proteasome inhibitors evoke latent tumor suppression programs in Pro-B MLL Leukemias through MLL-AF4

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CARFILZOMIB; CASPASE 8; HYBRID PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; MLL AF4 PROTEIN; PROTEASOME; PROTEIN BID; PROTEIN P27; UNCLASSIFIED DRUG;

EID: 84898467113     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2014.03.008     Document Type: Article
Times cited : (39)

References (62)
  • 1
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: a suitable antineoplastic target
    • Adams J. The proteasome: a suitable antineoplastic target. Nat. Rev. Cancer 2004, 4:349-360.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 349-360
    • Adams, J.1
  • 2
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton P.M., Cleary M.L. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 2001, 20:5695-5707.
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 4
    • 74049088297 scopus 로고    scopus 로고
    • High-risk childhood acute lymphoblastic leukemia
    • Bhojwani D., Howard S.C., Pui C.H. High-risk childhood acute lymphoblastic leukemia. Clin. Lymphoma Myeloma 2009, 9(Suppl 3):S222-S230.
    • (2009) Clin. Lymphoma Myeloma , vol.9 , Issue.SUPPL 3
    • Bhojwani, D.1    Howard, S.C.2    Pui, C.H.3
  • 5
    • 2542442633 scopus 로고    scopus 로고
    • Transcriptional control of early B cell development
    • Busslinger M. Transcriptional control of early B cell development. Annu. Rev. Immunol. 2004, 22:55-79.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 55-79
    • Busslinger, M.1
  • 6
    • 0034646247 scopus 로고    scopus 로고
    • The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation
    • Caslini C., Shilatifard A., Yang L., Hess J.L. The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. Proc. Natl. Acad. Sci. USA 2000, 97:2797-2802.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2797-2802
    • Caslini, C.1    Shilatifard, A.2    Yang, L.3    Hess, J.L.4
  • 8
    • 0034786019 scopus 로고    scopus 로고
    • BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • Cheng E.H., Wei M.C., Weiler S., Flavell R.A., Mak T.W., Lindsten T., Korsmeyer S.J. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 2001, 8:705-711.
    • (2001) Mol. Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1    Wei, M.C.2    Weiler, S.3    Flavell, R.A.4    Mak, T.W.5    Lindsten, T.6    Korsmeyer, S.J.7
  • 9
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
    • Chu I.M., Hengst L., Slingerland J.M. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat. Rev. Cancer 2008, 8:253-267.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 253-267
    • Chu, I.M.1    Hengst, L.2    Slingerland, J.M.3
  • 10
    • 84856283240 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system (UPS) and the mechanism of action of bortezomib
    • Cvek B., Dvorak Z. The ubiquitin-proteasome system (UPS) and the mechanism of action of bortezomib. Curr. Pharm. Des. 2011, 17:1483-1499.
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 1483-1499
    • Cvek, B.1    Dvorak, Z.2
  • 11
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: critical control points
    • Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 12
    • 84865736998 scopus 로고    scopus 로고
    • Targeting the B-cell lymphoma/leukemia 2 family in cancer
    • Davids M.S., Letai A. Targeting the B-cell lymphoma/leukemia 2 family in cancer. J.Clin. Oncol. 2012, 30:3127-3135.
    • (2012) J.Clin. Oncol. , vol.30 , pp. 3127-3135
    • Davids, M.S.1    Letai, A.2
  • 15
    • 1342305488 scopus 로고    scopus 로고
    • Malignant hematopoietic cell lines: invitro models for the study of MLL gene alterations
    • Drexler H.G., Quentmeier H., MacLeod R.A. Malignant hematopoietic cell lines: invitro models for the study of MLL gene alterations. Leukemia 2004, 18:227-232.
    • (2004) Leukemia , vol.18 , pp. 227-232
    • Drexler, H.G.1    Quentmeier, H.2    MacLeod, R.A.3
  • 17
    • 39749136204 scopus 로고    scopus 로고
    • BCL-2 family regulation by the 20S proteasome inhibitor bortezomib
    • Fennell D.A., Chacko A., Mutti L. BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 2008, 27:1189-1197.
    • (2008) Oncogene , vol.27 , pp. 1189-1197
    • Fennell, D.A.1    Chacko, A.2    Mutti, L.3
  • 20
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 24
    • 0345276803 scopus 로고    scopus 로고
    • Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression
    • Hsieh J.J., Cheng E.H., Korsmeyer S.J. Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 2003, 115:293-303.
    • (2003) Cell , vol.115 , pp. 293-303
    • Hsieh, J.J.1    Cheng, E.H.2    Korsmeyer, S.J.3
  • 28
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov A.V., Armstrong S.A. MLL translocations, histone modifications and leukaemia stem-cell development. Nat. Rev. Cancer 2007, 7:823-833.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 29
    • 67650357912 scopus 로고    scopus 로고
    • Therapeutic targeting of MLL
    • Liedtke M., Cleary M.L. Therapeutic targeting of MLL. Blood 2009, 113:6061-6068.
    • (2009) Blood , vol.113 , pp. 6061-6068
    • Liedtke, M.1    Cleary, M.L.2
  • 30
    • 34948839290 scopus 로고    scopus 로고
    • Bimodal degradation of MLL bySCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions
    • Liu H., Cheng E.H., Hsieh J.J. Bimodal degradation of MLL bySCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. Genes Dev. 2007, 21:2385-2398.
    • (2007) Genes Dev. , vol.21 , pp. 2385-2398
    • Liu, H.1    Cheng, E.H.2    Hsieh, J.J.3
  • 33
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • Lowe S.W., Cepero E., Evan G. Intrinsic tumour suppression. Nature 2004, 432:307-315.
    • (2004) Nature , vol.432 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 35
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: oncogene and non-oncogene addiction
    • Luo J., Solimini N.L., Elledge S.J. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009, 136:823-837.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 36
    • 0037374549 scopus 로고    scopus 로고
    • Selective cyclin-dependent kinase 2/cyclin Aantagonists that differ from ATP site inhibitors block tumor growth
    • Mendoza N., Fong S., Marsters J., Koeppen H., Schwall R., Wickramasinghe D. Selective cyclin-dependent kinase 2/cyclin Aantagonists that differ from ATP site inhibitors block tumor growth. Cancer Res. 2003, 63:1020-1024.
    • (2003) Cancer Res. , vol.63 , pp. 1020-1024
    • Mendoza, N.1    Fong, S.2    Marsters, J.3    Koeppen, H.4    Schwall, R.5    Wickramasinghe, D.6
  • 39
    • 77957128551 scopus 로고    scopus 로고
    • Licensed to elongate: amolecular mechanism for MLL-based leukaemogenesis
    • Mohan M., Lin C., Guest E., Shilatifard A. Licensed to elongate: amolecular mechanism for MLL-based leukaemogenesis. Nat. Rev. Cancer 2010, 10:721-728.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 721-728
    • Mohan, M.1    Lin, C.2    Guest, E.3    Shilatifard, A.4
  • 40
    • 84856916060 scopus 로고    scopus 로고
    • The pathogenesis of mixed-lineage leukemia
    • Muntean A.G., Hess J.L. The pathogenesis of mixed-lineage leukemia. Annu. Rev. Pathol. 2012, 7:283-301.
    • (2012) Annu. Rev. Pathol. , vol.7 , pp. 283-301
    • Muntean, A.G.1    Hess, J.L.2
  • 44
    • 0037013147 scopus 로고    scopus 로고
    • Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    • Pelengaris S., Khan M., Evan G.I. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 2002, 109:321-334.
    • (2002) Cell , vol.109 , pp. 321-334
    • Pelengaris, S.1    Khan, M.2    Evan, G.I.3
  • 45
    • 84871623647 scopus 로고    scopus 로고
    • Delving deeper: MCL-1's contributions to normal and cancer biology
    • Perciavalle R.M., Opferman J.T. Delving deeper: MCL-1's contributions to normal and cancer biology. Trends Cell Biol. 2013, 23:22-29.
    • (2013) Trends Cell Biol. , vol.23 , pp. 22-29
    • Perciavalle, R.M.1    Opferman, J.T.2
  • 48
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: setting the stage for molecularly targeted cancer therapy
    • Sharma S.V., Settleman J. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev. 2007, 21:3214-3231.
    • (2007) Genes Dev. , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 53
    • 27744524941 scopus 로고    scopus 로고
    • Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells
    • Thomas M., Gessner A., Vornlocher H.P., Hadwiger P., Greil J., Heidenreich O. Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood 2005, 106:3559-3566.
    • (2005) Blood , vol.106 , pp. 3559-3566
    • Thomas, M.1    Gessner, A.2    Vornlocher, H.P.3    Hadwiger, P.4    Greil, J.5    Heidenreich, O.6
  • 55
    • 84856879033 scopus 로고    scopus 로고
    • From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia
    • Walensky L.D. From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia. J.Clin. Oncol. 2012, 30:554-557.
    • (2012) J.Clin. Oncol. , vol.30 , pp. 554-557
    • Walensky, L.D.1
  • 56
    • 55249120170 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
    • Wang Z., Smith K.S., Murphy M., Piloto O., Somervaille T.C., Cleary M.L. Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature 2008, 455:1205-1209.
    • (2008) Nature , vol.455 , pp. 1205-1209
    • Wang, Z.1    Smith, K.S.2    Murphy, M.3    Piloto, O.4    Somervaille, T.C.5    Cleary, M.L.6
  • 57
    • 84856603153 scopus 로고    scopus 로고
    • ECSASB2 mediates MLL degradation during hematopoietic differentiation
    • Wang J., Muntean A.G., Hess J.L. ECSASB2 mediates MLL degradation during hematopoietic differentiation. Blood 2012, 119:1151-1161.
    • (2012) Blood , vol.119 , pp. 1151-1161
    • Wang, J.1    Muntean, A.G.2    Hess, J.L.3
  • 59
    • 84877676204 scopus 로고    scopus 로고
    • Mixed lineage leukemia protein in normal and leukemic stem cells
    • Yip B.H., So C.W. Mixed lineage leukemia protein in normal and leukemic stem cells. Exp. Biol. Med. (Maywood) 2013, 238:315-323.
    • (2013) Exp. Biol. Med. (Maywood) , vol.238 , pp. 315-323
    • Yip, B.H.1    So, C.W.2
  • 60
    • 26844555530 scopus 로고    scopus 로고
    • The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
    • Yokoyama A., Somervaille T.C., Smith K.S., Rozenblatt-Rosen O., Meyerson M., Cleary M.L. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell 2005, 123:207-218.
    • (2005) Cell , vol.123 , pp. 207-218
    • Yokoyama, A.1    Somervaille, T.C.2    Smith, K.S.3    Rozenblatt-Rosen, O.4    Meyerson, M.5    Cleary, M.L.6
  • 61
    • 76349118080 scopus 로고    scopus 로고
    • A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
    • Yokoyama A., Lin M., Naresh A., Kitabayashi I., Cleary M.L. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell 2010, 17:198-212.
    • (2010) Cancer Cell , vol.17 , pp. 198-212
    • Yokoyama, A.1    Lin, M.2    Naresh, A.3    Kitabayashi, I.4    Cleary, M.L.5
  • 62
    • 84888011157 scopus 로고    scopus 로고
    • P27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia
    • Zhang J., Seet C.S., Sun C., Li J., You D., Volk A., Breslin P., Li X., Wei W., Qian Z., et al. p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia. Mol. Oncol. 2013, 7:1069-1082.
    • (2013) Mol. Oncol. , vol.7 , pp. 1069-1082
    • Zhang, J.1    Seet, C.S.2    Sun, C.3    Li, J.4    You, D.5    Volk, A.6    Breslin, P.7    Li, X.8    Wei, W.9    Qian, Z.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.