Parathyroid hormone-related peptide plasma concentrations in patients on hemodialysis

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 74, Issue 3, 2014, Pages 206-212

  Nordholm, Anders ^a   Rix, Marianne ^a   Olgaard, Klaus ^a   Lewin, Ewa ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Hemodialysis; Hyperplasia; Parathyroid gland; PTHrP; Secondary hyperparathyroidism; Uremia

Indexed keywords

CALCIMIMETIC AGENT; CALCIUM ANTAGONIST; CALCIUM ION; COLECALCIFEROL; ERGOCALCIFEROL; MINERAL; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATE BINDING AGENT; VITAMIN D DERIVATIVE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HOMEOSTASIS; HORMONE BLOOD LEVEL; HUMAN; HYPOCALCEMIA; MAJOR CLINICAL STUDY; MALE; PARATHYROIDECTOMY; PRIORITY JOURNAL; BLOOD; CASE CONTROL STUDY; CROSS-SECTIONAL STUDY; METABOLISM; MIDDLE AGED; PARATHYROID GLAND; PATHOPHYSIOLOGY; RENAL REPLACEMENT THERAPY; UREMIA; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PARATHYROID GLANDS; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; RENAL DIALYSIS; UREMIA;

EID: 84898466083     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2013.876656     Document Type: Article

References (40)

1. Berl T, Henrich W. Kidney-heart interactions: Epidemiology, pathogenesis, and treatment. Clin J Am Soc Nephrol 2006;1:8-18
2. Go AS, Chertow G M, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. NEngl J Med 2004;351:1296-305
3. Levin A, Bakris G L, Molitch M, Smulders M, Tian J, Williams LA, Andress DL. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease. Kidney Int 2007;71:31-8
4. Drueke T B. Cell biology of parathyroid gland hyperplasia in chronic renal failure. JAm Soc Nephrol 2000;11:1141-52
5. Rodriguez M, Canalejo A, Garfi a B, Aguilera E, Almaden Y. Pathogenesis of refractory secondary hyperparathyroidism. Kidney Int Suppl 2002;155-60
6. Valimaki S, Farnebo F, Forsberg L, Larsson C, Farnebo LO. Heterogeneous expression of receptor mRNAs in parathyroid glands of secondary hyperparathyroidism. Kidney Int 2001;60:1666-75
7. Kifor O, Moore F D J r, Wang P, Goldstein M, Vassilev P, Kifor I, Hebert SC, Brown EM. Reduced immunostaining for the extracellular Ca2 -sensing receptor in primary and uremic secondary hyperparathyroidism. JClin Endocrinol Metab 1996;81:1598-606
8. de Francisco AM, Ellis H A, Owen J P, Cassidy MJ, Farndon JR, Ward MK, Kerr DN. Parathyroidectomy in chronic renal failure. Q J Med 1985;55:289-315
9. Matsushita H, Hara M, Endo Y, Shishiba Y, Hara S, Ubara Y, Nakazawa H, Suzuki N, Kawaminami K, Kido T, Li Q, Grimelius L. Proliferation of parathyroid cells negatively correlates with expression of parathyroid hormone-related protein in secondary parathyroid hyperplasia. Kidney Int 1999;55:130-8
10. Lewin E, Almaden Y, Rodriguez M, Olgaard K. PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid glands. Kidney Int 2000;58:71-81
11. Mannstadt M, Juppner H, Gardella TJ. Receptors for PTH and PTHrP: Their biological importance and functional properties. Am J Physiol 1999;277:F665-75
12. Suva L J, Winslow G A, Wettenhall R E, Hammonds R G, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodriguez H, Chen EY. Aparathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression. Science 1987;237:893-6
13. Martin TJ, Moseley J M, Williams E D. Parathyroid hormone-related protein: Hormone and cytokine. JEndocrinol 1997;154(Suppl .): S23-37
14. Karaplis AC, Vautour L. Parathyroid hormonerelated peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development. Curr Opin Nephrol Hypertens 1997;6:308-13
15. Orloff J J, Reddy D, d e Papp AE, Yang K H, Soifer N E, Stewart AF. Parathyroid hormone-related protein as a prohormone: Posttranslational processing and receptor interactions. Endocr Rev 1994;15:40-60
16. Care A D, Caple I W, Abbas S K, Pickard DW. The effect of fetal thyroparathyroidectomy on the transport of calcium across the ovine placenta to the fetus. Placenta 1986;7:417-24
17. Massfelder T, Fiaschi-Taesch N, Stewart AF, Helwig JJ. Parathyroid hormone-related peptide-A smooth muscle tone and proliferation regulatory protein. Curr Opin Nephrol Hypertens 1998;7:27-32
18. Karaplis A C, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 1994;8:277-89
19. Ikeda K, Weir EC, Mangin M, Dannies P S, Kinder B, Deftos LJ, Brown EM, Broadus AE. Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas. Mol Endocrinol 1988;2:1230-6
20. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specifi c ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 2013;154:3031-42
21. Moseley J M, Hayman J A, Danks J A, Alcorn D, Grill V, Southby J, Horton MA. Immunohistochemical detection of parathyroid hormone-related protein in human fetal epithelia. JClin Endocrinol Metab 1991;73:478-84
22. MacIsaac RJ, Heath JA, Rodda CP, Moseley JM, Care AD, Martin TJ, Caple IW. Role of the fetal parathyroid glands and parathyroid hormone-related protein in the regulation of placental transport of calcium, magnesium and inorganic phosphate. Reprod Fertil Dev 1991;3:447-57
23. Rodda C P, Kubota M, Heath J A, Ebeling P R, Moseley JM, Care AD, Caple IW, Martin TJ. Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: Comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy. J Endocrinol 1988;117:261-71
24. Tucci J, Russell A, Senior PV, Fernley R, Ferraro T, Beck F. The expression of parathyroid hormone and parathyroid hormone-related protein in developing rat parathyroid glands. JMol Endocrinol 1996;17:149-57
25. Connor C, Drees B, Hamilton J. Parathyroid hormonelike peptide and parathyroid hormone are secreted from bovine parathyroid via different pathways. Biochim Biophys Acta 1993;1178:81-6
26. Danks J A, Ebeling P R, Hayman J A, Diefenbach-Jagger H, Collier FM, Grill V, Southby J, Moseley JM, Chou ST, Martin TJ. Immunohistochemical localization of parathyroid hormone-related protein in parathyroid adenoma and hyperplasia. JPathol 1990;161:27-33
27. Docherty HM, Ratcliffe WA, Heath DA, Docherty K. Expression of parathyroid hormone-related protein in abnormal human parathyroids. JEndocrinol 1991;129:431-8
28. Matsushita H, Usui M, Hara M, Shishiba Y, Nakazawa H, Honda K, Torigoe K, Kohno K, Kurimoto M. Co-secretion of parathyroid hormone and parathyroidhormone-related protein via a regulated pathway in human parathyroid adenoma cells. Am J Pathol 1997;150:861-71
29. Ritter C S, Haughey B H, Miller B, Brown AJ. Differential gene expression by oxyphil and chief cells of human parathyroid glands. JClin Endocrinol Metab 2012;97:E1499-505
30. Kronenberg HM. PTHrP and skeletal development. Ann NY Acad Sci 2006;1068:1-13
31. de Miguel F, Motellon JL, Hurtado J, Jimenez FJ, Esbrit P. Comparison of two immunoradiometric assays for parathyroid hormone-related protein in the evaluation of cancer patients with and without hypercalcemia. Clin Chim Acta 1998;277:171-80
32. Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defi ning the roles of parathyroid hormonerelated protein in normal physiology. Physiol Rev 1996;76:127-73
33. Mangin M, Webb AC, Dreyer B E, Posillico J T, Ikeda K, Weir EC, Stewart AF, Bander NH, Milstone L, Barton DE. Identifi cation of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 1988;85:597-601
34. Takahashi S, Hakuta M, Aiba K, Ito Y, Horikoshi N, Miura M, Hatake K, Ogata E. Elevation of circulating plasma cytokines in cancer patients with high plasma parathyroid hormone-related protein levels. Endocr Relat Cancer 2003;10:403-7
35. Grill V, Hillary J, H o PM, Law FM, MacIsaac RJ, MacIsaac IA, Moseley JM, Martin TJ. Parathyroid hormonerelated protein: A possible endocrine function in lactation. Clin Endocrinol (Oxf) 1992;37:405-10
36. Bucht E, Rong H, Bremme K, Granberg B, Rian E, Torring O. Midmolecular parathyroid hormone-related peptide in serum during pregnancy, lactation and in umbilical cord blood. Eur J Endocrinol 1995;132:438-43
37. Power D M, Ingleton PM, Flanagan J, Canario A V, Danks J, Elgar G, Clark MS. Genomic structure and expression of parathyroid hormone-related protein gene (PTHrP) in a teleost, Fugu rubripes. Gene 2000;250:67-76
38. de Francisco A L, Izquierdo M, Cunningham J, Pinera C, Palomar R, Fresnedo GF, Amado JA, Unzueta MG, Arias M. Calcium-mediated parathyroid hormone release changes in patients treated with the calcimimetic agent cinacalcet. Nephrol Dial Transplant 2008;23:2895-901
39. Basile C, Lomonte C, Vernaglione L, Casucci F, Chimienti D, Bruno A, Cocola S, Verrelli EA, Cazzato F. Ahigh body mass index and female gender are associated with an increased risk of nodular hyperplasia of parathyroid glands in chronic uraemia. Nephrol Dial Transplant 2006;21:968-74
40. Lewin E, Garfi a B, Almaden Y, Rodriguez M, Olgaard K. Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic rats. Kidney Int 2003;64:63-70