Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

Journal of Molecular Medicine

Volumn 92, Issue 3, 2014, Pages 267-276

  Manu, Kanjoormana A ^a   Shanmugam, Muthu K ^a   Li, Feng ^a   Chen, Luxi ^a,b   Siveen, Kodappully Sivaraman ^a   Ahn, Kwang Seok ^c   Kumar, Alan Prem ^a,b,d,e   Sethi, Gautam ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Kyung Hee University   (South Korea)

^d CURTIN UNIVERSITY   (Australia)

^e UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

Apoptosis; Chemoresistance; Gastric cancer; NF B; Simvastatin

Indexed keywords

CAPECITABINE; CHEMOKINE RECEPTOR; CXC MOTIF RECEPTOR 4; CYCLIN D1; CYCLOOXYGENASE 2; GELATINASE B; I KAPPA B; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN BCL 2; PROTEIN BCL XL; RECEPTOR PROTEIN; SIMVASTATIN; SURVIVIN; TUMOR MARKER; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING ASSAY; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; COMPARATIVE STUDY; DNA BINDING; DRUG EFFICACY; DRUG SENSITIZATION; ENZYME REPRESSION; FEMALE; FLOW CYTOMETRY; GENE CONTROL; GENE PRODUCT; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA ISOLATION; STOMACH CANCER; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYCYTIDINE; DISEASE MODELS, ANIMAL; DNA; FEMALE; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PROTEIN BINDING; SIMVASTATIN; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898461040     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-1095-0     Document Type: Article

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