Design of nanodrugs for miRNA targeting in tumor cells

Journal of Biomedical Nanotechnology

Volumn 10, Issue 6, 2014, Pages 1114-1122

  Yoo, Byunghee ^a   Ghosh, Subrata K ^a   Kumar, Mohanraja ^a,b   Moore, Anna ^a   Yigit, Mehmet V ^a,c   Medarova, Zdravka ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Delivery vehicle; Gene silencing; Integrin specific peptide; Iron oxide nanoparticles; Locked nucleic acids; Microrna

Indexed keywords

CELLS; CYTOLOGY; DESIGN; ESTERIFICATION; ESTERS; LOCKS (FASTENERS); METAL NANOPARTICLES; OLIGONUCLEOTIDES; PEPTIDES; TUMORS;

DELIVERY VEHICLE; GENE SILENCING; INTEGRINS; IRON OXIDE NANOPARTICLE; LOCKED NUCLEIC ACID; MICRORNAS;

RNA;

ANTISENSE OLIGONUCLEOTIDE; DEXTRAN; DRUG; IRON OXIDE; LOCKED NUCLEIC ACID; MAGNETIC NANOPARTICLE; MICRORNA; N (GAMMA MALEIMIDOBUTYRYLOXY)SUCCINIMIDE ESTER); N SUCCINIMIDYL 3 (2 PYRIDYLDITHIO) PROPIONATE); NANODRUG; OLIGONUCLEOTIDE; PEPTIDE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONJUGATION; CONTROLLED STUDY; CYTOSOL; DRUG DESIGN; DRUG STABILITY; INCUBATION TIME; INTRACELLULAR SPACE; PEPTIDE SYNTHESIS; PHENOTYPE; TREATMENT RESPONSE; TUMOR CELL;

CELL LINE, TUMOR; DRUG DESIGN; GENETIC THERAPY; HUMANS; MICRORNAS; MOLECULAR TARGETED THERAPY; NANOCAPSULES; NEOPLASMS, EXPERIMENTAL; PARTICLE SIZE;

EID: 84898460995     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1795     Document Type: Article

References (27)

1. J. Winter, S. Jung, S. Keller, R. I. Gregory, and S. Diederichs, Many roads to maturity: MicroRNA biogenesis pathways and their regulation. Nat. Cell Biol. 11, 228 (2009).
2. D. P. Bartel, MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281 (2004).
3. A. Eulalio, E. Huntzinger, and E. Izaurralde, Getting to the root of miRNA-mediated gene silencing. Cell 132, 9 (2008).
4. W. Filipowicz, S. N. Bhattacharyya, and N. Sonenberg, Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat. Rev. Genet. 9, 102 (2008).
5. M. V. Iorio and C. M. Croce, MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics, a comprehensive review. EMBO Mol. Med. 4, 143 (2012).
6. M. S. Nicoloso, R. Spizzo, M. Shimizu, S. Rossi, and G. A. Calin, MicroRNAs - The micro steering wheel of tumour metastases. Nat. Rev. Cancer 9, 293 (2009).
7. L. Ma, J. Teruya-Feldstein, and R. A. Weinberg, Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449, 682 (2007).
8. D. R. Hurst, M. D. Edmonds, and D. R. Welch, Metastamir: The field of metastasis-regulatory microRNA is spreading. Cancer Res. 69, 7495 (2009).
9. G. Gabriely, M. Yi, R. S. Narayan, J. M. Niers, T. Wurdinger, J. Imitola, K. L. Ligon, S. Kesari, C. Esau, and R. M. Stephens, Human glioma growth is controlled by microRNA-10b. Cancer Res. 71, 3563 (2011).
10. K. A. Lennox and M. A. Behlke, A direct comparison of anti-microRNA oligonucleotide potency. Pharm. Res. 27, 1788 (2010).
11. M. Yigit, S. Ghosh, M. Kumar, V. Petkova, A. Kavishwar, A. Moore, and Z. Medarova, Context-dependent differences in miR-10b breast oncogenesis can be targeted for the prevention and arrest of lymph node metastasis. Oncogene 32, 1530 (2012).
12. Z. Medarova, W. Pham, C. Farrar, V. Petkova, and A. Moore, In vivo imaging of siRNA delivery and silencing in tumors. Nat. Med. 13, 372 (2007).
13. A. M. Derfus, A. A. Chen, D. H-. Min, E. Ruoslahti, and S. N. Bhatia, Targeted quantum dot conjugates for siRNA delivery. Bioconjugate Chem. 18, 1391 (2007).
14. N. Singh, A. Agrawal, A. K. Leung, P. A. Sharp, and S. N. Bhatia, Effect of nanoparticle conjugation on gene silencing by RNA interference. J. Am. Chem. Soc. 132, 8241 (2010).
15. A. M. Derfus, G. von Maltzahn, T. J. Harris, T. Duza, K. S. Vecchio, E. Ruoslahti, and S. N. Bhatia, Remotely triggered release from magnetic nanoparticles. Adv. Mater. 19, 3932 (2007).
16. O. Veiseh, F. M. Kievit, C. Fang, N. Mu, S. Jana, M. C. Leung, H. Mok, R. G. Ellenbogen, J. O. Park, and M. Zhang, Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Biomaterials 31, 8032 (2010).
17. L. X. Tiefenauer, G. Kuehne, and R. Y. Andres, Antibody-magnetite nanoparticles: In vitro characterization of a potential tumor-specific contrast agent for magnetic resonance imaging. Bioconjugate Chem. 4, 347 (1993).
18. J.-H. Lee, Y.-M. Huh, Y.-W. Jun, J.-W. Seo, J.-T. Jang, H.-T. Song, S. Kim, E.-J. Cho, H.-G. Yoon, and J.-S. Suh, Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat. Med. 13, 95 (2006).
19. J.-H. Park, G. Von Maltzahn, M. J. Xu, V. Fogal, V. R. Kotamraju, E. Ruoslahti, S. N. Bhatia, and M. J. Sailor, Cooperative nanomaterial system to sensitize, target, and treat tumors. Proc. Natl. Acad. Sci. USA 107, 981 (2010).
20. M. Canete, J. Soriano, A. Villanueva, A. G. Roca, S. Veintemillas, C. J. Serna, R. Miranda, and M. Del Puerto Morales, The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: a morphological approach. Int. J. Mol. Med. 26, 533 (2010).
21. S. D. Perrault, C. Walkey, T. Jennings, H. C. Fischer, and W. C. Chan, Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett. 9, 1909 (2009).
22. E. Song, S. K. Lee, D. M. Dykxhoorn, C. Novina, D. Zhang, K. Crawford, J. Cerny, P. A. Sharp, J. Lieberman, N. Manjunath, and P. Shankar, Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J. Virol. 77, 7174 (2003).
23. F. Sonvico, S. P. Mornet, S. B. Vasseur, C. Dubernet, D. Jaillard, J. Degrouard, J. Hoebeke, E. Duguet, P. Colombo, and P. Couvreur, Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: Synthesis, physicochemical characterization, and in vitro experiments. Bioconjugate Chem. 16, 1181 (2005).
24. D. B. Kirpotin, D. C. Drummond, Y. Shao, M. R. Shalaby, K. Hong, U. B. Nielsen, J. D. Marks, C. C. Benz, and J. W. Park, Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res. 66, 6732 (2006).
25. X. Huang, X. Peng, Y. Wang, Y. Wang, D. M. Shin, M. A. El-Sayed, and S. Nie, A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands. ACS Nano 4, 5887 (2010).
26. D. W. Bartlett, H. Su, I. J. Hildebrandt, W. A. Weber, and M. E. Davis, Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc. Natl. Acad. Sci. USA 104, 15549 (2007).
27. M. Kumar, M. Yigit, G. Dai, A. Moore, and Z. Medarova, Image-guided breast tumor therapy using a small interfering RNA nanodrug. Cancer Res. 70, 7553 (2010).