Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: Synthesis, physicochemical characterization, and in vitro experiments

Bioconjugate Chemistry

Volumn 16, Issue 5, 2005, Pages 1181-1188

  Sonvico, Fabio ^a,b,d   Mornet, Stéphane ^c   Vasseur, Sébastien ^c   Dubernet, Catherine ^a   Jaillard, Danielle ^e   Degrouard, Jeril ^e   Hoebeke, Johan ^f   Duguet, Etienne ^c   Colombo, Paolo ^b   Couvreur, Patrick ^a,g  

^a UNIV PARIS SUD   (France)

^b UNIVERSITY OF PARMA   (Italy)

^c INST CHIM MATIERE COND BORDEAUX   (France)

^d INFM   (Italy)

^e CNRS   (France)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; HYPERTHERMIA THERAPY; IRON OXIDES; NANOMAGNETICS; NANOSYSTEMS; ORGANIC ACIDS; SURFACE PLASMON RESONANCE; SURFACE TREATMENT; SYNTHESIS (CHEMICAL); TUMORS;

CELL LINES; FOLATE RECEPTOR; FOLATES; FOLIC ACIDS; IN-VITRO; MAGHEMITE NANOPARTICLE; MAGNETIC HYPERTHERMIA; PHYSICO-CHEMICAL CHARACTERIZATION; SOLID TUMORS; TUMOR-TARGETING;

NANOPARTICLES;

FERRIC OXIDE; FOLATE RECEPTOR; FOLIC ACID; NANOPARTICLE; SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; BINDING COMPETITION; COLLOID; CONJUGATION; DRUG CYTOTOXICITY; DRUG TARGETING; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERTHERMIA; IN VITRO STUDY; INTERNALIZATION; IONIC STRENGTH; ISOTOPE LABELING; MAGNETIC FIELD; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SOLID TUMOR; SURFACE PLASMON RESONANCE; SURFACE PROPERTY; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL;

EID: 25444482796     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc050050z     Document Type: Article

References (39)

1. Davis, S. S. (1997) Biomedical applications of nanotechnology- implications for drug targeting and gene therapy. Trends Biotechnol. 15, 217-224.
2. Brigger, I., Dubernet, C., and Couvreur, P. (2002) Nanoparticles in cancer therapy and diagnosis. Adv. Drug Del. Rev. 54, 631-651.
3. Sonvico, F., Dubernet, C., Colombo, P., and Couvreur, P. Metallic based nanotechnology, applications in diagnosis and therapeutics. Curr. Pharm. Des. 11, 2091-2105.
4. Mornet, S., Vasseur, S., Grasset, F., and Duguet, E. (2004) Magnetic nanoparticles for medical diagnosis and therapy. J. Mater. Chem. 14, 2161-2175.
5. Weissleder, R., and Papisov, M. (1992) Pharmaceutical iron oxides for MR imaging. Rev. Magn. Reson. Med. 4, 1-20.
6. Weissleder, R., Bogdanov, A., Neuwelt, E. A., and Papisov, M. (1995) Long circulating iron oxides for MR imaging. Adv. Drug Del. Rev. 16, 321-334.
7. Gilchrist, R. K., Medal, R., Shorey, W. D., Hanselman, R. C., Parott, J. C., and Taylor, C. B. (1957) Selective inductive heating of lymph nodes. Ann. Surg. 146, 596-606.
8. van der Zee, J. (2002) Heating the patient: a promising approach? Ann. Oncol. 13, 1173-1184.
9. Hildebrandt, B., Wust, P., Ahlers, O., Dieing, A., Sreenivasa, G., Kerner, T., Felix, R., and Riess, H. (2002) The cellular and molecular basis of hyperthermia. Crit. Rev. Oncol. Hematol. 43, 33-56.
10. Engin, K. (1996) Biological rationale and clinical experience with hyperthermia. Control. Clin. Trials 17, 316-342.
11. Gordon, R. T., Hines, J. R., and Gordon, D. (1979) Intracellular Hyperthermia - A biophysical approach to cancer treatment via intracellular temperature and biphysical alteration. Med. Hypotheses 5, 83-102.
12. Moroz, P., Jones, S. K., and Gray, B. N. (2002) Magnetically mediated hyperthermia: current status and future directions. Int. J. Hyperthermia 18, 267-284.
13. Jordan, A., Scholz, R., Maier-Hauff, K., Johannsen, M., Wust, P., Nadobny, J., Schirra, H., Schmidt, H., Deger, S., Loening, S., Lanksch, W., and Felix, R. (2001) Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia. J. Magn. Magn. Mater. 225, 118-126.
14. Bacri, J. C., Da Silva, M. F., Perzynski, R., Pons, J. N., Roger, J., Sabolovic, D., and Halbreich, A. (1997) Use of magnetic nanoparticles for thermolysis of cells in a ferrofluid. Scientific and clinical applications of magnetic carriers. Häfeli, U., Schutt, W., Teller, J., and Zborowski, M., Eds. pp 597-606, Plenum Press, New York.
15. Jordan, A., Scholz, R., Wust, P., Schirra, H., Schiestel, T., Schmidt, H., and Felix, R. (1999) Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro. J. Magn. Magn. Mater. 194, 185-196.
16. Pitsillides, C. M., Joe, E. K., Wei, X., Anderson, R. R., and Lin, C. P. (2003) Selective cell targeting with light-absorbing microparticles and nanoparticles. Biophys. J. 84, 4023-4032.
17. Mornet, S., Portier, J., and Duguet, E. (2003) Ferrofluides stables en milieu neutre et ferrofluides modifiés obtenus par modification de la surface des particules de ces ferrofluides. French Patent 0306279.
18. Mornet, S., Portier, J., and Duguet, E. (2005) A method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran. J. Magn. Magn. Mater. 293, 127-134.
19. Massart, R. (1982) Magnetic fluids and process for obtaining them. U.S. Patent 4,329,241.
20. Lee, R. J., and Low, P. S. (1994) Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J. Biol. Chem. 295, 3198-3204.
21. Lemarchand, C., Couvreur, P., Besnard, M., Costantini, D., and Gref, R. (2003) Novel polyester-polysaccharide nanoparticles. Pharm. Res. 20, 1284-1292.
22. Johnsson, B., Lofas, S., and Lindquist, G. (1991) Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal. Biochem. 198, 268-277.
23. Antony, A. C. (1992) The biological chemistry of folate receptors. Blood 79, 2807-2820.
24. Gabizon, A., Horowitz, A. T., Goren, D., Tzemach, D., Mandelbaum-Shavit, F., Qazen, M. M., and Zalipsky, S. (1999) Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: in vitro studies. Bioconjug. Chem. 10, 289-298.
25. Sonvico, F., Stella, B., Appel, M., Chacun, H., Marsaud, V., Renoir, M., Colombo, P., and Couvreur, P. Setup of an in vitro model expressing the folate receptor for the investigation of targeted delivery systems. J. Drug Delivery Sci. Technol., in press.
26. Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B. (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47, 936-942.
27. Salmaso, S., Semenzato, A., Caliceti, P., Hoebeke, J., Sonvico, F., Dubernet, C., and Couvreur, P. (2004) Specific antitumor targetable beta-cyclodextrin-poly(ethylene glycol)-folic acid drug delivery bioconjugate. Bioconjug. Chem. 15, 997-1004.
28. Pinto-Alphandary, H., Balland, O., and Couvreur, P. (1995) A new method to isolate polyalkylcyanoacrylate nanoparticle preparations. J. Drug Target. 3, 167-169.
29. Bootz, A., Vogel, V., Schubert, D., and Kreuter, J: (2004) Comparison of scanning electron microscopy, dynamic light scattering and analytical ultracentrifugation for the sizing of poly(butyl cyanoacrylate) nanoparticles. Eur. J. Pharm. Biopharm. 57, 369-375.
30. Csaba, N., Caamano, P., Sanchez, A., Dominguez, F., and Alonso, M. J. (2005) PLGA: poloxamer and PLGA: poloxamine blend nanoparticles: new carriers for gene delivery. Biomacromolecules 6, 271-278.
31. Petri-Fink, A., Chastellain, M., Juillerat-Jeanneret, L., Ferrari, A., and Hofmann, H. (2005) Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells. Biomaterials 26, 2685-2694.
32. Zhang, Y., Sun, C., Kohler, N., and Zhang, M. (2004) Self-assembled coatings on individual monodisperse magnetite nanoparticles for efficient intracellular uptake. Biomed. Microdevices 6, 33-40.
33. Zhang, Y., Kohler, N., and Zhang, M. (2002) Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomater. 23, 1553-1561.
34. Lemarchand, C., Gref, R., and Couvreur, P. (2004) Polysaccharide- decorated nanoparticles. Eur. J. Pharm. Biopharm. 58, 327-341.
35. Moghimi, S. M., Hunter, A. C., and Murray, J. C. (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53, 283-318.
36. Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., and Jain, R. K. (1998) Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. U.S.A. 95, 4607-4612.
37. Gabizon, A. A. (2001) Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet. Clin. Cancer Res. 7, 223-225.
38. Mislick, K. A., Baldeschwieler, J. D., Kayyem, J. F., and Meade, T. J. (1995) Transfection of folate-polylysine DNA complexes: evidence for lysosomal delivery. Bioconjugate Chem. 6, 512-515.
39. Jansen, G., Barr, H., Kathmann, I., Bunni, M. A., Priest, D. G., Noordhuis, P., Peters, G. J., and Assaraf, Y. G. (1999) Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded Mate pools, and intralysosomal drug sequestration. Mol. Pharmacol. 55, 761-769.