메뉴 건너뛰기




Volumn 57, Issue 7, 2014, Pages 2843-2844

Efficient hit and lead compound evaluation strategy based on off-rate screening by surface plasmon resonance

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 90 INHIBITOR; LEAD; ORGANIC SOLVENT;

EID: 84898444292     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5003815     Document Type: Article
Times cited : (13)

References (13)
  • 2
    • 74749088503 scopus 로고    scopus 로고
    • Spending on new drug development
    • Adams, C. P.; Brantner, V. V. Spending on new drug development Health Econ. 2010, 19, 130-141
    • (2010) Health Econ. , vol.19 , pp. 130-141
    • Adams, C.P.1    Brantner, V.V.2
  • 3
    • 84883809894 scopus 로고    scopus 로고
    • Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies
    • Bryan, M. C.; Hein, C. D.; Gao, H.; Xia, X.; Eastwood, H.; Bruenner, B. A.; Louie, S. W.; Doherty, E. M. Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies ACS Comb. Sci. 2013, 15, 503-511
    • (2013) ACS Comb. Sci. , vol.15 , pp. 503-511
    • Bryan, M.C.1    Hein, C.D.2    Gao, H.3    Xia, X.4    Eastwood, H.5    Bruenner, B.A.6    Louie, S.W.7    Doherty, E.M.8
  • 6
    • 84872088566 scopus 로고    scopus 로고
    • Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography
    • Guetzoyan, L.; Nikbin, N.; Baxendale, I. R.; Ley, S. V. Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography Chem. Sci. 2013, 4, 764-769
    • (2013) Chem. Sci. , vol.4 , pp. 764-769
    • Guetzoyan, L.1    Nikbin, N.2    Baxendale, I.R.3    Ley, S.V.4
  • 8
    • 84898474395 scopus 로고    scopus 로고
    • Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products
    • DOI: 10.1021/jm401848a.
    • Murray, J. B.; Roughley, S. D.; Matassova, N.; Brough, P. A. Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products. J. Med. Chem. 2014, DOI: 10.1021/jm401848a.
    • (2014) J. Med. Chem.
    • Murray, J.B.1    Roughley, S.D.2    Matassova, N.3    Brough, P.A.4
  • 11
    • 77649260308 scopus 로고    scopus 로고
    • Fragment-based drug discovery: Concept and aim
    • Tanaka, D. Fragment-based drug discovery: concept and aim Yakugaku Zasshi 2010, 130, 315-23
    • (2010) Yakugaku Zasshi , vol.130 , pp. 315-323
    • Tanaka, D.1
  • 12
    • 80255131239 scopus 로고    scopus 로고
    • Kinetic efficiency: The missing metric for enhancing compound quality?
    • Holdgate, G. A.; Gill, A. L. Kinetic efficiency: the missing metric for enhancing compound quality? Drug Discovery Today 2011, 16, 910-913
    • (2011) Drug Discovery Today , vol.16 , pp. 910-913
    • Holdgate, G.A.1    Gill, A.L.2
  • 13
    • 84875016493 scopus 로고    scopus 로고
    • Free energy landscape for the binding process of huperzine A to acetylcholinesterase
    • Bai, F. Free energy landscape for the binding process of huperzine A to acetylcholinesterase Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 4273-4278
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 4273-4278
    • Bai, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.