DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia

Leukemia

Volumn 28, Issue 4, 2014, Pages 787-793

  Stevenson, W S ^a,b   Best, O G ^b   Przybylla, A ^b   Chen, Q ^a,b   Singh, N ^a   Koleth, M ^a   Pierce, S ^c   Kennedy, T ^a   Tong, W ^c   Kuang, S Q ^c   Garcia Manero, G ^c  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

non Hodgkin lymphoma; PTPRG; PTPRK; PTPRM; PTPRO

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; CYTARABINE; DIMETHYL SULFOXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STAT3 PROTEIN; STAT5 PROTEIN; VORINOSTAT;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER SURVIVAL; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DRUG SENSITIVITY; ENZYME ACTIVITY; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; INTRAARTERIAL DRUG ADMINISTRATION; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MALE; MEMBRANE BINDING; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; PTPRA GENE; PTPRG GENE; PTPRJ GENE; PTPRK GENE; PTPRM GENE; PTPRO GENE; PTPRU GENE;

ADOLESCENT; ADULT; AGED; CELL LINE, TUMOR; CELL PROLIFERATION; CPG ISLANDS; DNA METHYLATION; HUMANS; JANUS KINASE 1; MIDDLE AGED; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC; PROPORTIONAL HAZARDS MODELS; PROTEIN TYROSINE PHOSPHATASES; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR;

EID: 84898441850     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.270     Document Type: Article

References (31)

1. Garcia-Manero G, Daniel J, Smith TL, Kornblau SM, Lee MS, Kantarjian HM et al. DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. Clin Cancer Res 2002; 8: 2217-2224. (Pubitemid 34753593)
2. Taylor KH, Pena-Hernandez KE, Davis JW, Arthur GL, Duff DJ, Shi H et al. Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia. Cancer Res 2007; 67: 2617-2625. (Pubitemid 46548948)
3. Shen L, Toyota M, Kondo Y, Obata T, Daniel S, Pierce S et al. Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood 2003; 101: 4131-4136. (Pubitemid 36857895)
4. Bueso-Ramos C, Xu Y, McDonnell TJ, Brisbay S, Pierce S, Kantarjian H et al. Protein expression of a triad of frequently methylated genes, p73, p57Kip2 and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. J Clin Oncol 2005; 23: 3932-3939. (Pubitemid 46218696)
5. Canalli AA, Yang H, Jeha S, Hoshino K, Sanchez-Gonzalez B, Brandt M et al. Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia. Leuk Res 2005; 29: 881-885. (Pubitemid 40840715)
6. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A et al. Protein tyrosine phosphatases in the human genome. Cell 2004; 117: 699-711. (Pubitemid 38748887)
7. Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ et al. Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism. Science 2007; 317: 1217-1220.
8. Gebbink MF, Zondaq GC, Koningstein GM, Feiken E, Wubbolts RW, Moolenaar WH. Cell surface expression of receptor protein tyrosine phosphatase RPTP m is regulated by cell-cell contact. J Cell Biol 1995; 131: 251-260.
9. Sap J, Jiang YP, Friedlander D, Grumet M, Schlessinger J. Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding. Mol Cell Biol 1994; 14: 1-9.
10. Wang SE, Wu FY, Shin I, Qu S, Arteaga CL. Transforming growth factor b (TGF-b)-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-b function. Mol Cell Biol 2005; 25: 4703-4715. (Pubitemid 40705773)
11. Novellino L, De Filippo A, Deho P, Perrone F, Pilotti S, Parmiani G et al. PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells. Cell Signal 2008; 20: 872-883.
12. Xu Y, Tan LJ, Grachtchouk V, Voorhees JJ, Fisher GJ. Receptor-type proteintyrosine phosphatase-kappa regulates epidermal growth factor receptor function. J Biol Chem 2005; 280: 42694-42700. (Pubitemid 43049228)
13. Xu Y, Baker D, Quan T, Baldassare JJ, Voorhees JJ, Fisher GJ. Receptor type protein tyrosine phosphatase-kappa mediates cross-talk between transforming growth factor-beta and epidermal growth factor receptor signaling pathways in human keratinocytes. Mol Biol Cell 2010; 21: 29-35.
14. Sanchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits b-catenin transcriptional activity in lung cancer cells. Mol Cell Biol 2011; 31: 3286-3297.
15. Flavell JR, Baumforth KR, Wood VH, Davies GL, Wei W, Reynolds GM et al. Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. Blood 2008; 111: 292-301.
16. Kleppe M, Soulier J, Asnafi V, Mentens N, Hornakova T, Knoops L et al. PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia. Blood 2011; 117: 7090-7098.
17. Porcu M, Kleppe M, Gianfelici V, Geerdens E, De Keersmaecker K, Tartaglia M et al. Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia. Blood 2012; 119: 4476-4479.
18. Kuang SQ, Tong WG, Yang H, Lin W, Lee MK, Fang ZH et al. Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia. Leukemia 2008; 22: 1529-1538.
19. Shu J, Jelinek J, Chang H, Shen L, Qin T, Chung W et al. Silencing of bidirectional promoters by DNA methylation in tumorigenesis. Cancer Res 2006; 66: 5077-5084. (Pubitemid 43844929)
20. Tong WG, Wierda WG, Lin E, Kuang SQ, Bekele BN, Estrov Z et al. Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact. Epigenetics 2010; 5: 499-508.
21. Motiwala T, Majumder S, Kutay H, Smith DS, Neuberg DS, Lucas DM et al. Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia. Clin Cancer Res 2007; 13: 3174-3181. (Pubitemid 46944899)
22. Godfrey R, Arora D, Bauer R, Stopp S, Mü ller JP, Heinrich T et al. Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/PTPRJ. Blood 2012; 119: 4499-4511.
23. Maksumova L, Wang Y, Wong NK, Le HT, Pallen CJ, Johnson P. Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45. J Biol Chem 2007; 282: 20925-20932. (Pubitemid 47099952)
24. Wang B, Kishihara K, Zhang D, Hara H, Nomoto K. Molecular cloning and characterization of a novel human receptor protein tyrosine phophatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells. Biochem Biophys Res Commun 1997; 231: 77-81. (Pubitemid 27212112)
25. Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34: 148-150. (Pubitemid 36666923)
26. Kuang SQ, Bai H, Fang ZH, Lopez G, Yang H, Tong W et al. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. Blood 2010; 115: 2412-2419.
27. Gutierrez MI, Siraj AK, Bhargava M, Ozbek U, Banavali S, Chaudhary MA et al. Concurrent methylation of multiple genes in childhood ALL: correlation with phenotype and molecular subgroup. Leukemia 2003; 17: 1845-1850. (Pubitemid 37185261)
28. Hogan LE, Meyer JA, Yang J, Wang J, Wong N, Yang W et al. Intergrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies. Blood 2011; 118: 5218-5226.
29. Bhatla T, Wang J, Morrison DJ, Raetz EA, Burke MJ, Brown P et al. Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia. Blood 2012; 119: 5201-5210.
30. Motiwala T, Majumder S, Ghoshal K, Kutay H, Datta J, Roy S et al. PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells. J Biol Chem 2009; 284: 455-464.
31. Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genomewide DNA copy number alterations, clinical characteristics, and outcome. Blood 2010; 116: 4874-4884.