Protein expression of a triad of frequently methylated genes, p73, p57 Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status

Journal of Clinical Oncology

Volumn 23, Issue 17, 2005, Pages 3932-3939

  Bueso Ramos, Carlos ^a   Xu, Yunling ^a   McDonnell, Timothy J ^a   Brisbay, Shawn ^a   Pierce, Sherry ^a   Kantarjian, Hagop ^a   Rosner, Gary ^a   Garcia Manero, Guillermo ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1C; PROTEIN P15; PROTEIN P57; PROTEIN P73; CDKN1C PROTEIN, HUMAN; CDKN2B PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DNA; DNA BINDING PROTEIN; ENZYME INHIBITOR; NUCLEAR PROTEIN; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P73;

ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; CANCER SURVIVAL; CELL CYCLE REGULATION; CONTROLLED STUDY; DNA METHYLATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TISSUE MICROARRAY; DISEASE FREE SURVIVAL; ENZYME IMMUNOASSAY; GENETICS; METABOLISM; MIDDLE AGED; PROMOTER REGION; SURVIVAL RATE; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P57; DISEASE-FREE SURVIVAL; DNA METHYLATION; DNA, NEOPLASM; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 21244483122     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.02.998     Document Type: Article

References (24)

1. Robertson KD, Wolffe AP: DNA methylation in health and disease. Nat Rev Genet 1:11-19, 2000
2. Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042-2054, 2003
3. Garcia-Manero G, Daniel J, Smith TL, et al: DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. Clin Cancer Res 8:2217-2224, 2002
4. Shen L, Toyota M, Kondo Y, et al: Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood 101:4131-4136, 2003
5. Kantarjian HM, O'Brien S, Smith TL, et al: Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol 18:547-561, 2000
6. Xiong Z, Laird PW: COBRA: A sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25:2532-2534, 1997
7. Corn PG, Kuerbitz SJ, van Noesel MM, et al: Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation. Cancer Res 59:3352-3356, 1999
8. Garcia-Manero G, Jena S, Daniel J, et al: Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia. Cancer 97:695-702, 2003
9. Gutierrez MI, Siraj AK, Bhargava M, et al: Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup. Leukemia 17:1845-1850, 2003
10. Roman-Gomez J, Jimenez-Velasco A, Castillejo JA, et al: Promoter hypermethylation of cancer-related genes: A strong independent prognostic factor in acute lymphoblastic leukemia. Blood 104:2492-2498, 2004
11. Herman JG, Civin CI, Issa JP, et al: Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 57:837-841, 1997
12. Garcia-Manero G, Bueso-Ramos C, Daniel J, et al: DNA methylation patterns at relapse in adult acute lymphocytic leukemia. Clin Cancer Res 8:1897-1903, 2002
13. Kawano S, Miller CW, Gombart AF, et al: Loss of p73 gene expression in leukemias/ lymphomas due to hypermethylation. Blood 94:1113-1120, 1999
14. Blint E, Phillips AC, Kozlov S, et al: Induction of p57(KIP2) expression by p73beta. Proc Natl Acad Sci U S A 99:3529-3534, 2002
15. Elledge SJ: Cell cycle checkpoints: Preventing an identity crisis. Science 274:1664-1672, 1996
16. Sherr CJ: The Pezcoller lecture: Cancer cell cycles revisited. Cancer Res 60:3689-3695, 2000
17. Wong IH, Ng MH, Huang DP, et al: Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: Potential prognostic implications. Blood 95:1942-1949, 2000
18. Li Y, Nagai H, Ohno T, et al: Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype. Blood 100:2572-2577, 2002
19. Kikuchi T, Toyota M, Itoh F, et al: Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors. Oncogene 21:2741-2749, 2002
20. Zhang P, Liegeois NJ, Wong C, et al: Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beck-with-Wiedemann syndrome. Nature 387:151-158, 1997
21. Yang A, Walker N, Bronson R, et al: p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404:99-103, 2000
22. Malumbres M, Sotillo R, Santamaria D, et al: Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118:493-504, 2004
23. Kozar K, Ciemerych MA, Rebel VI, et al: Mouse development and cell proliferation in the absence of D-cyclins. Cell 118:477-491, 2004
24. Shen L, Kondo Y, Issa JP, et al: Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia. Blood 100:3432-3433, 2002