In vitro model suggests oxidative stress involved in keratoconus disease

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Karamichos, D ^a   Hutcheon, A E K ^b   Rich, C B ^d   Trinkaus Randall, V ^d   Asara, J M ^c   Zieske, J D ^b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASCORBIC ACID; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; GLUTATHIONE; KERA PROTEIN, HUMAN; LACTIC ACID; MALIC ACID; MALIC ACID DERIVATIVE; PROTEOGLYCAN; PYRUVIC ACID; TRANSFORMING GROWTH FACTOR BETA3;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CORNEA; CORNEA CELL; CYTOLOGY; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; KERATOCONUS; METABOLISM; METABOLOMICS; MYOFIBROBLAST; OXIDATIVE STRESS; PATHOLOGY;

ARGININE; ASCORBIC ACID; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE III; COLLAGEN TYPE IV; CORNEA; CORNEAL KERATOCYTES; EXTRACELLULAR MATRIX; FIBROBLASTS; GLUTATHIONE; HUMANS; KERATOCONUS; LACTIC ACID; MALATES; METABOLOMICS; MYOFIBROBLASTS; OXIDATIVE STRESS; PROTEOGLYCANS; PYRUVIC ACID; TRANSFORMING GROWTH FACTOR BETA3;

EID: 84898406344     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04608     Document Type: Article

References (59)

1. Spoerl, E.,Huhle, M.&Seiler, T. Induction of cross-links in corneal tissue. Exp Eye Res. 66, 97-103, doi:10.1006/exer.1997.0410 (1998) (Pubitemid 28070342)
2. Sporl, E., Schreiber, J., Hellmund, K., Seiler, T. & Knuschke, P. [Studies on the stabilization of the cornea in rabbits]. Zeitschrift der DOG 97, 203-206 (2000)
3. Rahi, A., Davies, P., Ruben, M., Lobascher, D. & Menon, J. Keratoconus and coexisting atopic disease. Br J Ophthalmol. 61, 761-764, doi:DOI 10.1136/ bjo.61.12.761 (1977) (Pubitemid 8283148)
4. Gasset, A. R., Hinson, W. A. & Frias, J. L. Keratoconus and atopic diseases. Ann Ophthalmol. 10, 991-994 (1978) (Pubitemid 9005779)
5. Bawazeer, A. M., Hodge, W. G. & Lorimer, B. Atopy and keratoconus: a multivariate analysis. Br JOphthalmol. 84, 834-836, doi:Doi 10.1136/Bjo.84.8.834 (2000) (Pubitemid 30599086)
6. Cullen, J. F.&Butler, H. G. Mongolism (Down's Syndrome) and Keratoconus. Br J Ophthalmol. 47, 321-330 (1963)
7. Shapiro, M. B. & France, T. D. The ocular features of Down's syndrome. Am J Ophthalmol. 99, 659-663 (1985) (Pubitemid 15059937)
8. Robertson, I. Keratoconus and the Ehlers-Danlos syndrome: a new aspect of keratoconus. Med J Aust. 1, 571-573 (1975)
9. Woodward, E. G.&Morris, M. T. Joint hypermobility in keratoconus. Ophthalmic Physiol Opt. 10, 360-362 (1990) (Pubitemid 20353995)
10. Pierse, D.&Eustace, P. Acute keratoconus in mongols. Br JOphthalmol. 55, 50-54 (1971)
11. Udar, N. et al. SOD1: a candidate gene for keratoconus. Invest Ophth Vis Sci. 47, 3345-3351, doi:10.1167/iovs.05-1500 (2006) (Pubitemid 351639696)
12. Nowak, D. M. & Gajecka, M. The genetics of keratoconus. MEAJO. 18, 2-6, doi:10.4103/0974-9233.75876 (2011)
13. Halliwell, B. Oxidative stress and cancer: have we moved forward? Biochem J. 401, 1-11, doi:Doi 10.1042/Bj20061131 (2007) (Pubitemid 46115897)
14. Valko, M. et al. Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology 39, 44-84, doi:10.1016/j.biocel.2006.07.001 (2007) (Pubitemid 44566469)
15. Singh, N., Dhalla, A. K., Seneviratne, C. & Singal, P. K. Oxidative stress and heart failure. Mol Cell Biochem. 147, 77-81 (1995)
16. Dean, O. M. et al. N-acetyl cysteine restores brain glutathione loss in combined 2- cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder. Neurosci Lett. 499, 149-153, doi:10.1016/ j.neulet.2011.05.027 (2011)
17. Ramond, A. et al. Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia. FCP. 27, 252-261, doi:10.1111/j.1472- 8206.2011.01015.x (2011)
18. Kenney,M. C., Brown, D. J. & Rajeev, B. Everett Kinsey lecture. The elusive causes of keratoconus: a working hypothesis. CLAO J. 26, 10-13 (2000) (Pubitemid 30053807)
19. Greiner, J. V., Kopp, S. J. & Glonek, T. Phosphorus nuclear magnetic resonance and ocular metabolism. Surv Ophthalmol. 30, 189-202 (1985)
20. Risa, O. et al. Metabolic changes in rat lens after in vivo exposure to ultraviolet irradiation: measurements by high resolution MAS 1H NMRspectroscopy. Invest Ophth Vis Sci. 45, 1916-1921 (2004) (Pubitemid 38868990)
21. Karamichos, D. et al. Novel in vitro model for keratoconus disease. JFB. 3, 760-775, doi:10.3390/jfb3040760 (2012)
22. Locasale, J. W. et al. Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. Molecular & cellular proteomics: MCP. 11, M111 014688, doi:10.1074/mcp.M111.014688 (2012)
23. Kelly, A. D. et al.Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma. PLoS One 6, e25357, doi:10.1371/journal.pone.0025357 (2011)
24. Yuan, M., Breitkopf, S. B., Yang, X. & Asara, J. M. A positive/negative ionswitching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue. N prot. 7, 872-881, doi:10.1038/ nprot.2012.024 (2012)
25. Webhofer, C. et al. Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates. J Psychiatr Res. 47, 289-298, doi:10.1016/j.jpsychires. 2012.11.003 (2013)
26. Guo, X. et al. Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophth Vis Sci. 48, 4050-4060, doi:10.1167/iovs.06-1216 (2007) (Pubitemid 351261029)
27. Karamichos, D., Hutcheon, A. E. & Zieske, J. D. Transforming growth factorbeta3 regulates assembly of a non-fibrotic matrix in a 3Dcorneal model. JTERM 5, e228-238, doi:10.1002/term.429 (2011)
28. Karamichos, D. et al. TGF-beta3 stimulates stromal matrix assembly by human corneal keratocyte-like cells. Invest Ophth Vis Sci. 54, 6612-6619, doi:10.1167/ iovs.13-12861 (2013)
29. Webhofer, C. et al. Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates. J Psychiatr Res. 47, 289-298, doi:DOI 10.1016/ j.jpsychires.2012.11.003 (2013)
30. Xia, J. G., Psychogios, N., Young, N. &Wishart, D. S. MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res. 37, W652-W660, doi:Doi 10.1093/Nar/Gkp356 (2009)
31. Klyce, S. D. Stromal lactate accumulation can account for corneal oedema osmotically following epithelial hypoxia in the rabbit. J Physiol. 321, 49-64 (1981) (Pubitemid 12248083)
32. Doherty, J. R. & Cleveland, J. L. Targeting lactate metabolism for cancer therapeutics. JCI. 123, 3685-3692, doi:10.1172/JCI69741 (2013)
33. Schutte, E., Schulz, I.&Reim,M. Lactate and pyruvate levels in the aqueous humor and in the cornea after cyclodiathermy. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 185, 325-330 (1972)
34. Li, G. B., Lee, P., Mori, N., Yamamoto, I. & Arai, T. Long term intensive exercise training leads to a higher plasma malate/lactate dehydrogenase (M/L) ratio and increased level of lipid mobilization in horses. Vet Res Commun. 36, 149-155, doi:DOI 10.1007/s11259-012-9515-0 (2012)
35. Magalhaes, J. et al.Oxidative stress in humans during and after 4 hours of hypoxia at a simulated altitude of 5500 m. Aviat Space Environ Med. 75, 16-22 (2004) (Pubitemid 38040659)
36. Zitka, O. et al. Redox status expressed as GSH:GSSG ratio as amarker for oxidative stress in paediatric tumour patients. Oncol Lett. 4, 1247-1253, doi:Doi 10.3892/ Ol.2012.931 (2012)
37. Chai, Y. C., Ashraf, S. S., Rokutan, K., Johnston, R. B., Jr. & Thomas, J. A. Sthiolation of individual human neutrophil proteins including actin by stimulation of the respiratory burst: evidence against a role for glutathione disulfide. Arch Biochem Biophys. 310, 273-281, doi:10.1006/abbi. 1994.1167 (1994) (Pubitemid 24171496)
38. Arnal, E., Peris-Martinez, C., Menezo, J. L., Johnsen-Soriano, S. & Romero, F. J. Oxidative stress in keratoconus? Invest Ophth Vis Sci. 52, 8592-8597, doi:10.1167/ iovs.11-7732 (2011)
39. Fu, H. et al. Arginine depletion as a mechanism for the immune privilege of corneal allografts. Eur J Immunol. 41, 2997-3005, doi:DOI 10.1002/eji.201141683 (2011)
40. Nguyen T. T. &Bonanno, J. A. Lactate-H1 transport is a significant component of the in vivo corneal endothelial pump. Invest Ophth Vis Sci. 53, 2020-2029, doi:Doi 10.1167/Iovs.12-9475 (2012)
41. Paracha, U. Z. et al. Oxidative stress and hepatitis C virus. Virology J. 10, 251, doi:10.1186/1743-422X-10-251 (2013)
42. Seaver, L. C. & Imlay, J. A. Are respiratory enzymes the primary sources of intracellular hydrogen peroxide? JBC. 279, 48742-48750, doi:10.1074/ jbc.M408754200 (2004) (Pubitemid 39625751)
43. Cadenas, E. Mitochondrial free radical production and cell signaling. Mol Aspects Med. 25, 17-26, doi:10.1016/j.mam.2004.02.005 (2004) (Pubitemid 38401928)
44. Pollack, M. & Leeuwenburgh, C. Apoptosis and aging: role of the mitochondria. Journals Gerontol A Biol Sci Med Sci. 56, B475-482 (2001) (Pubitemid 33043471)
45. Lee, H. C. & Wei, Y. H. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Bio. 37, 822-834, doi:10.1016/j.biocel.2004.09.010 (2005) (Pubitemid 40203003)
46. Mugge, A. et al. Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ Res. 69, 1293-1300 (1991)
47. Miller, F. J., Jr., Gutterman, D. D., Rios, C. D., Heistad, D. D. & Davidson, B. L. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res. 82, 1298-1305 (1998) (Pubitemid 28294749)
48. Houstis, N., Rosen, E. D. & Lander, E. S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440, 944-948, doi:10.1038/ nature04634 (2006)
49. Chwa,M. et al. Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts. Invest Ophth Vis Sci 49, 4361-4369, doi:10.1167/iovs.08- 1969 (2008)
50. Karicherla, P., Aras, S., Aiyar, A. & Hobden, J. A. Nona-D-arginine amide suppresses corneal cytokines in Pseudomonas aeruginosa keratitis. Cornea. 29, 1308-1314, doi:10.1097/ICO.0b013e3181ca3a69 (2010)
51. Pompella, A., Visvikis, A., Paolicchi, A., De Tata, V. & Casini, A. F. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol. 66, 1499-1503 (2003) (Pubitemid 38373339)
52. Gondhowiardjo, T. D. et al. Analysis of corneal aldehyde dehydrogenase patterns in pathologic corneas. Cornea 12, 146-154 (1993) (Pubitemid 23099068)
53. Gondhowiardjo, T. D. & van Haeringen, N. J. Corneal aldehyde dehydrogenase, glutathione reductase, and glutathione S-transferase in pathologic corneas. Cornea. 12, 310-314 (1993) (Pubitemid 23182126)
54. Buddi, R. et al. Evidence of oxidative stress in human corneal diseases. JHistochem Cytochem. 50, 341-351 (2002) (Pubitemid 34173022)
55. Wenk, J. et al. UV-induced oxidative stress and photoaging. Curr Probl Dermatol. 29, 83-94 (2001)
56. Abedinia, M., Pain, T., Algar, E. M. & Holmes, R. S. Bovine corneal aldehyde dehydrogenase: the major soluble corneal protein with a possible dual protective role for the eye. Exp Eye Res. 51, 419-426 (1990) (Pubitemid 20315319)
57. Rao, N. A., Romero, J. L., Fernandez, M. A., Sevanian, A. &Marak, G. E., Jr. Role of free radicals in uveitis. Surv Ophthalmol. 32, 209-213 (1987) (Pubitemid 18008543)
58. Brooker, R. J. Genetics: Analysis and Principles. 4th edn, (McGraw-Hill Science, 2011)
59. Devasagayam, T. P. et al. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India. 52, 794-804 (2004) (Pubitemid 41279997)