Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model

Journal of Tissue Engineering and Regenerative Medicine

Volumn 5, Issue 8, 2011, Pages

  Karamichos, D ^a   Hutcheon, A E K ^a   Zieske, J D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Collagen; Cornea; Corneal fibroblasts; Extracellular matrix; Fibrosis; Growth factors; TGF 3; Vitamin C

Indexed keywords

CELL CULTURE; FIBROBLASTS; TISSUE; TISSUE ENGINEERING;

CORNEA; CORNEAL FIBROBLASTS; EXTRACELLULAR MATRICES; FIBROSE; GROWTH FACTOR; HUMAN CORNEAL; ISOFORMS; MATRIX; TGFΒ3; VITAMIN C;

COLLAGEN;

ASCORBIC ACID DERIVATIVE; COLLAGEN TYPE 3; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; CORNEA CELL; ENZYME REGULATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTERMETHOD COMPARISON; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; TISSUE ENGINEERING; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EID: 79960559043     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.429     Document Type: Article

References (56)

1. Alaminos M, Del Carmen Sanchez-Quevedo M, Munoz-Avila JI, et al. 2006; Construction of a complete rabbit cornea substitute using a fibrin-agarose scaffold. Invest Ophthalmol Vis Sci 47(8): 3311-3317.
2. Bleckmann H, Holak S. 2006; Preliminary results after implantation of four AlphaCor artificial corneas. Graefes Arch Clin Exp Ophthalmol 244(4): 502-506.
3. Border WA, Noble NA. 1994; Transforming growth factor-β in tissue fibrosis. N Engl J Med 331(19): 1286-1292.
4. Carrington LM, Albon J, Anderson I, et al. 2006; Differential regulation of key stages in early corneal wound healing by TGF-β isoforms and their inhibitors. Invest Ophthalmol Vis Sci 47(5): 1886-1894.
5. Chalam KV, Chokshi A, Agarwal S, et al. 2007; Complications of AlphaCor keratoprosthesis: a clinicopathologic report. Cornea 26(10): 1258-1260.
6. 1/S transition in response to corneal debridement. Invest Ophthalmol Vis Sci 40(9): 1952-1958.
7. Fagerholm P, Lagali NS, Carlsson DJ, et al. 2009; Corneal regeneration following implantation of a biomimetic tissue-engineered substitute. Clin Transl Sci 2(2): 162-164.
8. Gatherer D, Ten Dijke P, Baird DT, et al. 1990; Expression of TGF-β isoforms during first trimester human embryogenesis. Development 110(2): 445-4460.
9. Gipson IK, Grill SM, Spurr SJ, et al. 1983; Hemidesmosome formation in vitro. J Cell Biol 97(3): 849-857.
10. Gomaa A, Comyn O, Liu C. 2010; Keratoprostheses in clinical practice-a review. Clin Exp Ophthalmol 38(2): 211-224.
11. Gonzalez-Andrades M, Garzon I, Gascon MI, et al. 2009; Sequential development of intercellular junctions in bioengineered human corneas. J Tissue Eng Regen Med 3(6): 442-449.
12. Griffith M, Osborne R, Munger R, et al. 1999; Functional human corneal equivalents constructed from cell lines. Science 286(5447): 2169-2172.
13. Guo X, Hutcheon AEK, Melotti SA, et al. 2007; Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci 48(9): 4050-4060.
14. Hao J, Varshney RR and Wang DA. 2008; TGF-β3: a promising growth factor in engineered organogenesis. Expert Opin Biol Ther 8(10): 1485-1493.
15. Helena MC, Baerveldt F, Kim WJ, et al. 1998; Keratocyte apoptosis after corneal surgery. Invest Ophthalmol Vis Sci 39(2): 276-283.
16. Hicks CR, Crawford GJ, Dart JK, et al. 2006; AlphaCor: clinical outcomes. Cornea 25(9): 1034-1042.
17. Holak SA, Holak HM and Bleckmann H. 2009; AlphaCor keratoprosthesis: postoperative development of six patients. Graefes Arch Clin Exp Ophthalmol 247(4): 535-539.
18. Huang YX and Li QH. 2007; An active artificial cornea with the function of inducing new corneal tissue generation in vivo-a new approach to corneal tissue engineering. Biomed Mater 2(3): S121-S125.
19. Jester JV and Chang J-H. 2003; Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction. Exp Eye Res 77(5): 581-592.
20. Jester JV, Huang J, Petroll WM, et al. 2002; TGFβ-induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGFβ, PDGF and integrin signaling. Exp Eye Res 75(6): 645-657.
21. Jester JV, Petroll WM and Cavanagh HD. 1999; Corneal stromal wound healing in refractive surgery: the role of the myofibroblast. Prog Retinal Eye Res 18(3): 311-356.
22. Kane BP, Jester JV, Huang J, et al. 2009; IGF-II and collagen expression by keratocytes during postnatal development. Exp Eye Res 89(2): 218-223.
23. Karamichos D, Guo XQ, Hutcheon AEK, et al. 2010; Human corneal fibrosis: an in vitro model. Invest Ophthalmol Vis Sci 51(3): 1382-1388.
24. Kubota M and Fagerholm P. 1991; Corneal alkali burn in the rabbit. Water balance, healing and transparency. Acta Ophthalmol (Copenh) 69(5): 635-640.
25. Li F, Carlsson D, Lohmann C, et al. 2003; Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation. Proc Natl Acad Sci USA 100(26): 15346-15351.
26. Li WY, Huang EY, Dudas M, et al. 2006; Transforming growth factor-β3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction. Wound Repair Regen 14(5): 516-525.
27. Long CJ, Roth MR, Tasheva ES, et al. 2000; Fibroblast growth factor-2 promotes keratan sulfate proteoglycan expression by keratocytes in vitro. J Biol Chem 275(18): 13918-13923.
28. Mi S, Chen B, Wright B, et al. 2010; Plastic compression of a collagen gel forms a much improved scaffold for ocular surface tissue engineering over conventional collagen gels. J Biomed Mater Res A 95(2): 447-453.
29. Millan FA, Denhez F, Kondaiah P, et al. 1991; Embryonic gene expression patterns of TGFβ1, -β2 and -β3 suggest different developmental functions in vivo. Development 111(1): 131-143.
30. Minami Y, Sugihara H and Oono S. 1993; Reconstruction of cornea in three-dimensional collagen gel matrix culture. Invest Ophthalmol Vis Sci 34(7): 2316-2324.
31. Moller-Pedersen T, Vogel MD, Li H, et al. 1997; Quantification of stromal thinning, epithelial thickness, and corneal haze following photorefractive keratectomy using in vivo confocal microscopy. Ophthalmology 104(3): 360-368.
32. Musselmann K, Alexandrou B, Kane B, et al. 2005; Maintenance of the keratocyte phenotype during cell proliferation stimulated by insulin. J Biol Chem 280(38): 32634-32639.
33. Musselmann K, Kane BP, Alexandrou B, et al. 2008; IGF-II is present in bovine corneal stroma and activates keratocytes to proliferate in vitro. Exp Eye Res 86(3): 506-511.
34. Mustoe TA, Pierce GF, Thomason A, et al. 1987; Accelerated healing of incisional wounds in rats induced by transforming growth factor-β. Science 237(4820): 1333-1336.
35. O'Kane S and Ferguson MW. 1997; Transforming growth factor-βs and wound healing. Int J Biochem Cell Biol 29(1): 63-78.
36. Occleston NL, Laverty HG, O'Kane S, et al. 2008; Prevention and reduction of scarring in the skin by transforming growth factor-β3 (TGFβ3): from laboratory discovery to clinical pharmaceutical. J Biomater Sci Polym Ed 19(8): 1047-1063.
37. Pelton RW, Dickinson ME, Moses HL, et al. 1990; In situ hybridization analysis of TGFβ 3 RNA expression during mouse development: comparative studies with TGFβ1 and -β2. Development 110(2): 609-620.
38. Pelton RW, Saxena B, Jones M, et al. 1991; Immunohistochemical localization of TGFβ1, TGFβ2, and TGFβ3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol 115(4): 1091-1105.
39. Petroll WM, New K, Sachdev M, et al. 1992; Radial keratotomy III. Relationship between wound gape and corneal curvature in primate eyes. Invest Ophthal Vis Sci 33(12): 3283-3291.
40. Proulx S, d'Arc Uwamaliya J, Carrier P, et al. 2010; Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types. Mol Vis 16: 2192-2201.
41. Reichl S, Muller-Goymann CC. 2003; The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride. Int J Pharm 250(1): 191-201.
42. Ren R, Hutcheon AEK, Guo XQ, et al. 2008; Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3D cultures. Dev Dyn 237(10): 2705-2715.
43. Roberts AB, Sporn MB. 1992; Differential expression of the TGF-β isoforms in embryogenesis suggests specific roles in developing and adult tissues. Mol Reprod Dev 32(2): 91-98.
44. Schmid P, Cox D, Bilbe G, et al. 1991; Differential expression of TGFβ1, -β2 and -β3 genes during mouse embryogenesis. Development 111(1): 117-130.
45. Schneider AI, Maier-Reif K, Graeve T. 1999; Constructing an in vitro cornea from cultures of the three specific corneal cell types. In vitro Cell Dev Biol Anim 35(9): 515-526.
46. Shah M, Foreman DM, Ferguson MW. 1995; Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGFβ3 to cutaneous rat wounds reduces scarring. J Cell Sci 108(3): 985-1002.
47. Sporn MB, Roberts AB, Shull JH, et al. 1983; Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science 219(4590): 1329-1331.
48. Suzuki K, Saito J, Yanai R, et al. 2003; Cell-matrix and cell-cell interactions during corneal epithelial wound healing. Prog Retin Eye Res 22(2): 113-133.
49. Tseng SC, Li DQ and Ma X. 1999; Suppression of transforming growth factor-β isoforms, TGF-β receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol 179(3): 325-335.
50. Vrana NE, Builles N, Justin V, et al. 2008; Development of a reconstructed cornea from collagen-chondroitin sulfate foams and human cell cultures. Invest Ophthalmol Vis Sci 49(12): 5325-5331.
51. Wahl SM, Hunt DA, Wakefield LM, et al. 1987; Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA 84(16): 5788-5792.
52. Williams CG, Kim TK, Taboas A, et al. 2003; In vitro chondrogenesis of bone marrow-derived mesenchymal stem cells in a photopolymerizing hydrogel. Tissue Eng 9(4): 679-688.
53. Yao Y, Zhang F, Zhou R, et al. 2010; Continuous supply of TGFβ3 via adenoviral vector promotes type I collagen and viability of fibroblasts in alginate hydrogel. J Tissue Eng Regen Med 4(7): 497-504.
54. Younai S, Nichter LS, Wellisz T, et al. 1994; Modulation of collagen synthesis by transforming growth factor-β in keloid and hypertrophic scar fibroblasts. Ann Plast Surg 33(2): 148-151.
55. Zieske JD, Guimaraes SR, Hutcheon AEK. 2001; Kinetics of keratocyte proliferation in response to epithelial debridement. Exp Eye Res 72(1): 33-39.
56. Zieske JD, Mason VS, Wasson ME, et al. 1994; Basement membrane assembly and differentiation of cultured corneal cells: importance of culture environment and endothelial cell interaction. Exp Cell Res 214(2): 621-633.