Distinct regulation of tonsillar immune response in virus infection

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 69, Issue 5, 2014, Pages 658-667

  Jartti, Tuomas ^a   Palomares, O ^b,c   Waris, M ^d   Tastan, O ^e   Nieminen, R ^a   Puhakka, T ^a,f   Ruckert B ^b   Aab, A ^b   Vuorinen, T ^d   Allander, T ^g   Vahlberg, T ^d   Ruuskanen, O ^a   Akdis, M ^b   Akdis, C A ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d UNIVERSITY OF TURKU   (Finland)

^e BILKENT UNIVERSITY   (Turkey)

^f SATAKUNTA CENTRAL HOSPITAL   (Finland)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allergy; cytokine; T cell; tonsil; virus

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 28; INTERLEUKIN 29; INTERLEUKIN 37; PROTEIN RORC2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; TRANSCRIPTOME;

ADENOVIRUS; ADOLESCENT; ADULT; ALLERGY; ARTICLE; BOCAVIRUS; CHILD; CORONAVIRUS; ENTEROVIRUS; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INFLUENZA VIRUS; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; METAPNEUMOVIRUS; NASOPHARYNX; NONHUMAN; PALATINE TONSIL; PARAINFLUENZA VIRUS; POLYMERASE CHAIN REACTION SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RHINOVIRUS; T LYMPHOCYTE; TONSILLECTOMY; VIRUS DETECTION; VIRUS INFECTION; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; IMMUNOLOGY; METABOLISM; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; CHILD; CLUSTER ANALYSIS; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MALE; PALATINE TONSIL; TRANSCRIPTION FACTORS; TRANSCRIPTOME; VIRUS DISEASES; YOUNG ADULT;

EID: 84898401640     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12396     Document Type: Article

References (36)

1. Tan WC, Xiang X, Qiu D, Ng TP, Lam SF, Hegele RG,. Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. Am J Med 2003; 115: 272-277.
2. Grissell TV, Powell H, Shafren DR, Boyle MJ, Hensley MJ, Jones PD, et al. Interleukin-10 gene expression in acute virus-induced asthma. Am J Respir Crit Care Med 2005; 172: 433-439.
3. Allander T, Jartti T, Gupta S, Niesters HG, Lehtinen P, Osterback R, et al. Human bocavirus and acute wheezing in children. Clin Infect Dis 2007; 44: 904-910.
4. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178: 667-672.
5. Lukkarinen M, Lukkarinen H, Lehtinen P, Vuorinen T, Ruuskanen O, Jartti T,. Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up. Pediatr Allergy Immunol 2013; 24: 237-243.
6. Sigurs N, Aljassim F, Kjellman B, Robinson PD, Sigurbergsson F, Bjarnason R, et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax 2010; 65: 1045-1052.
7. Krishnamoorthy N, Khare A, Oriss TB, Raundhal M, Morse C, Yarlagadda M, et al. Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nat Med 2012; 18: 1525-1530.
8. Yamada K, Elliott WM, Brattsand R, Valeur A, Hogg JC, Hayashi S,. Molecular mechanisms of decreased steroid responsiveness induced by latent adenoviral infection in allergic lung inflammation. J Allergy Clin Immunol 2002; 109: 35-42.
9. Jartti T, Söderlund-Venermo M, Hedman K, Ruuskanen O, Mäkelä MJ,. New molecular virus detection methods and their clinical value in lower respiratory tract infections in children. Paediatr Respir Rev 2013; 14: 38-45.
10. Message SD, Laza-Stanca V, Mallia P, Parker HL, Zhu J, Kebadze T, et al. Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci U S A 2008; 105: 13562-13567.
11. Baraldo S, Contoli M, Bazzan E, Turato G, Padovani A, Marku B, et al. Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma. J Allergy Clin Immunol 2012; 130: 1307-1314.
12. Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO,. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 2003; 168: 633-639.
13. Lee DC, Harker JA, Tregoning JS, Atabani SF, Johansson C, Schwarze J, et al. CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol 2010; 84: 8790-8798.
14. Palomares O, Rückert B, Jartti T, Kücüksezer UC, Puhakka T, Gomez E, et al. Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance. J Allergy Clin Immunol 2012; 129: 510-520.
15. McClory S, Hughes T, Freud AG, Briercheck EL, Martin C, Trimboli AJ, et al. Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest 2012; 122: 1403-1415.
16. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199: 1567-1575.
17. Meiler F, Zumkehr J, Klunker S, Rückert B, Akdis CA, Akdis M,. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008; 205: 2887-2898.
18. Osterback R, Tevaluoto T, Ylinen T, Peltola V, Susi P, Hyypiä T, et al. Simultaneous detection and differentiation of human rhino- and enteroviruses in clinical specimens by real-time PCR with locked nucleic Acid probes. J Clin Microbiol 2013; 51: 3960-3967.
19. Fisher RA,. On the probable error of a coefficient of correlation deduced from a small sample. Metron 1921; 1: 3-32.
20. Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T,. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 2011; 27: 431-432.
21. Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA,. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 2010; 11: 1014-1022.
22. McNamee EN, Masterson JC, Jedlicka P, McManus M, Grenz A, Collins CB, et al. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci USA 2011; 108: 16711-16716.
23. Sakai N, Van Sweringen HL, Belizaire RM, Quillin RC, Schuster R, Blanchard J, et al. Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J Gastroenterol Hepatol 2012; 27: 1609-1616.
24. Sojka DK, Fowell DJ,. Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10. Proc Natl Acad Sci USA 2011; 108: 18336-18341.
25. Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, et al. Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011; 127: 701-721.
26. Gern JE, Brooks GD, Meyer P, Chang A, Shen K, Evans MD, et al. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol 2006; 117: 72-78.
27. Lee CC, Huang HY, Chiang BL,. Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness. Mol Ther 2008; 16: 60-65.
28. Campbell-Harding G, Sawkins H, Bedke N, Holgate ST, Davies DE, Andrews AL,. The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts. J Allergy Clin Immunol 2013; 131: 849-855.
29. Kücüksezer UC, Palomares O, Rückert B, Jartti T, Puhakka T, Nandy A, et al. Triggering of specific Toll-like receptors and proinflammatory cytokines break allergen-specific T cell tolerance in human tonsils and peripheral blood. J Allergy Clin Immunol 2013; 131: 875-885.
30. Jartti T, Kuusipalo H, Vuorinen T, Söderlund-Venermo M, Allander T, Waris M, et al. Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children. Pediatr Allergy Immunol 2010; 21: 1008-1014.
31. Jackson DJ, Johnston SL,. The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol 2010; 125: 1178-1187.
32. Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002; 295: 336-338.
33. Rubtsova K, Rubtsov AV, van Dyk LF, Kappler JW, Marrack P,. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci USA 2013; 110: E3216-E3224.
34. Fulop T, Larbi A, Wikby A, Mocchegiani E, Hirokawa K, Pawelec G,. Dysregulation of T-cell function in the elderly: scientific basis and clinical implications. Drugs Aging 2005; 22: 589-603.
35. Senti G, Crameri R, Kuster D, Johansen P, Martinez-Gomez JM, Graf N, et al. Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections. J Allergy Clin Immunol 2012; 129: 1290-1296.
36. Soyer OU, Akdis M, Ring J, Behrendt H, Crameri R, Lauener R, et al. Mechanisms of peripheral tolerance to allergens. Allergy 2013; 68: 161-170.