The CNK2 scaffold interacts with vilse and modulates rac cycling during spine morphogenesis in hippocampal neurons

Current Biology

Volumn 24, Issue 7, 2014, Pages 786-792

  Lim, Junghwa ^a   Ritt, Daniel A ^a   Zhou, Ming ^b   Morrison, Deborah K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CNKSR2 PROTEIN, HUMAN; RAC PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

CHEMISTRY; CYTOLOGY; DENDRITIC SPINE; HIPPOCAMPUS; HUMAN; METABOLISM; MORPHOGENESIS; PHYSIOLOGY; PROTEIN MOTIF; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; DENDRITIC SPINES; HIPPOCAMPUS; HUMANS; MORPHOGENESIS; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84898058620     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2014.02.036     Document Type: Article

References (26)

1. M. Therrien, A.M. Wong, and G.M. Rubin CNK, a RAF-binding multidomain protein required for RAS signaling Cell 95 1998 343 353
2. I. Yao, Y. Hata, N. Ide, K. Hirao, M. Deguchi, H. Nishioka, A. Mizoguchi, and Y. Takai MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein J. Biol. Chem. 274 1999 11889 11896
3. G. Houge, I.H. Rasmussen, and R. Hovland Loss-of-function CNKSR2 mutation is a likely cause of non-syndromic X-linked intellectual disability Mol. Syndromol. 2 2012 60 63
4. A. Renieri, C. Pescucci, I. Longo, F. Ariani, F. Mari, and I. Meloni Non-syndromic X-linked mental retardation: from a molecular to a clinical point of view J. Cell. Physiol. 204 2005 8 20
5. K. Ohtakara, M. Nishizawa, I. Izawa, Y. Hata, S. Matsushima, W. Taki, H. Inada, Y. Takai, and M. Inagaki Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1 Genes Cells 7 2002 1149 1160
6. T. Rajakulendran, M. Sahmi, I. Kurinov, M. Tyers, M. Therrien, and F. Sicheri CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling Proc. Natl. Acad. Sci. USA 105 2008 2836 2841
7. J. Lim, M. Zhou, T.D. Veenstra, and D.K. Morrison The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling Genes Dev. 24 2010 1496 1506
8. A. Lundström, M. Gallio, C. Englund, P. Steneberg, J. Hemphälä, P. Aspenström, K. Keleman, L. Falileeva, B.J. Dickson, and C. Samakovlis Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons Genes Dev. 18 2004 2161 2171
9. H. Hu, M. Li, J.P. Labrador, J. McEwen, E.C. Lai, C.S. Goodman, and G.J. Bashaw Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion Proc. Natl. Acad. Sci. USA 102 2005 4613 4618
10. K.M. Allen, J.G. Gleeson, S. Bagrodia, M.W. Partington, J.C. MacMillan, R.A. Cerione, J.C. Mulley, and C.A. Walsh PAK3 mutation in nonsyndromic X-linked mental retardation Nat. Genet. 20 1998 25 30
11. K. Kutsche, H. Yntema, A. Brandt, I. Jantke, H.G. Nothwang, U. Orth, M.G. Boavida, D. David, J. Chelly, and J.P. Fryns et al. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation Nat. Genet. 26 2000 247 250
12. R.T. Premont, S.J. Perry, R. Schmalzigaug, J.T. Roseman, Y. Xing, and A. Claing The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors Cell. Signal. 16 2004 1001 1011
13. M.J. Macias, S. Wiesner, and M. Sudol WW and SH3 domains, two different scaffolds to recognize proline-rich ligands FEBS Lett. 513 2002 30 37
14. I. Yao, T. Ohtsuka, H. Kawabe, Y. Matsuura, Y. Takai, and Y. Hata Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1 Biochem. Biophys. Res. Commun. 270 2000 538 542
15. T.M. Lanigan, A. Liu, Y.Z. Huang, L. Mei, B. Margolis, and K.L. Guan Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf FASEB J. 17 2003 2048 2060
16. K. Aoki, T. Nakamura, and M. Matsuda Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells J. Biol. Chem. 279 2004 713 719
17. M. Nikolic The role of Rho GTPases and associated kinases in regulating neurite outgrowth Int. J. Biochem. Cell Biol. 34 2002 731 745
18. R. Bumeister, C. Rosse, A. Anselmo, J. Camonis, and M.A. White CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation Curr. Biol. 14 2004 439 445
19. M. Dierssen, and G.J. Ramakers Dendritic pathology in mental retardation: from molecular genetics to neurobiology Genes Brain Behav. 5 Suppl 2 2006 48 60
20. A.Y. Nakayama, and L. Luo Intracellular signaling pathways that regulate dendritic spine morphogenesis Hippocampus 10 2000 582 586
21. I.M. Ethell, and E.B. Pasquale Molecular mechanisms of dendritic spine development and remodeling Prog. Neurobiol. 75 2005 161 205
22. A. Matus Growth of dendritic spines: a continuing story Curr. Opin. Neurobiol. 15 2005 67 72
23. H. Zhang, D.J. Webb, H. Asmussen, and A.F. Horwitz Synapse formation is regulated by the signaling adaptor GIT1 J. Cell Biol. 161 2003 131 142
24. H. Zhang, D.J. Webb, H. Asmussen, S. Niu, and A.F. Horwitz A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC J. Neurosci. 25 2005 3379 3388
25. J. Iida, W. Nishimura, I. Yao, and Y. Hata Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain Eur. J. Neurosci. 15 2002 1493 1498
26. N. Komatsu, K. Aoki, M. Yamada, H. Yukinaga, Y. Fujita, Y. Kamioka, and M. Matsuda Development of an optimized backbone of FRET biosensors for kinases and GTPases Mol. Biol. Cell 22 2011 4647 4656