CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 8, 2008, Pages 2836-2841

  Rajakulendran, Thanashan ^a,b   Sahmi, Malha ^c   Kurinov, Igor ^d,e   Tyers, Mike ^a,b   Therrien, Marc ^c,f   Sicheri, Frank ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^d Department of Obstetrics Gynecology   (United States)

^e ARGONNE NATIONAL LABORATORY   (United States)

^f UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

MAPK signaling; RAF activation; Sterile motif; X ray crystallography

Indexed keywords

RAF PROTEIN; CNK PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; KSR 1 PROTEIN KINASE; KSR-1 PROTEIN KINASE; PROTEIN KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STOICHIOMETRY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CRYSTALLIZATION; ESCHERICHIA COLI; GENETICS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CRYSTALLIZATION; DIMERIZATION; DROSOPHILA PROTEINS; ESCHERICHIA COLI; HUMANS; MODELS, MOLECULAR; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RAF KINASES; SIGNAL TRANSDUCTION;

EID: 42949170081     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709705105     Document Type: Article

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