Immunohistochemical localization of spatacsin in α-synucleinopathies

Neuropathology

Volumn 34, Issue 2, 2014, Pages 135-139

  Kuru, Satoshi ^a   Yoshida, Mari ^b   Tatsumi, Shinsui ^b   Mimuro, Maya ^b  

^a SUZUKA NATIONAL HOSPITAL   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Glial cytoplasmic inclusions; Immunohistochemistry; Lewy bodies; Spatacsin; synucleinopathies

Indexed keywords

ALPHA SYNUCLEIN; POLYCLONAL ANTIBODY; SPATACSIN ANTIBODY; UNCLASSIFIED DRUG; PROTEIN; SPG11 PROTEIN, HUMAN;

ADULT; AGED; ALPHA SYNUCLEINOPATHY; ANTIBODY LABELING; ARTICLE; BIOACCUMULATION; BRAIN; BRAIN CELL; BRAIN STEM; BRAIN TISSUE; CELL INCLUSION; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; FEMALE; GENE; GENE LOCATION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOCUS CERULEUS; MALE; NEURITE; NEUROLOGIC DISEASE; PARKINSON DISEASE; PATHOGENESIS; PONS; PRIORITY JOURNAL; SHY DRAGER SYNDROME; SPATACSIN GENE; SUBSTANTIA NIGRA; TEMPORAL CORTEX; AUTOPSY; METABOLISM; MIDDLE AGED; PATHOLOGY; TEMPORAL LOBE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; AUTOPSY; BRAIN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; LEWY BODY DISEASE; MALE; MIDDLE AGED; MULTIPLE SYSTEM ATROPHY; PARKINSON DISEASE; PROTEINS; TEMPORAL LOBE;

EID: 84898057356     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/neup.12069     Document Type: Article

References (17)

1. Hehr U, Bauer P, Winner B etal. Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia. Ann Neurol 2007; 62: 656-665.
2. Paisan-Ruiz C, Dogu O, Yilmaz A, Houlden H, Singleton A. SPG11 mutations are common in familial cases of complicated hereditary spastic paraplegia. Neurology 2008; 70: 1384-1389.
3. Southgate L, Dafou D, Hoyle J etal. Novel SPG11 mutations in Asian kindreds and disruption of spatacsin function in the zebrafish. Neurogenetics 2010; 211: 379-389.
4. Stevanin G, Azzedine H, Denora P etal. Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. Brain 2008; 131: 772-784.
5. Murmu RP, Martin E, Rastetter A etal. Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia. Mol Cell Neurosci 2011; 47: 191-202.
6. Anheim M, Lagier-Tourenne C, Stevanin G etal. SPG11 spastic paraplegia. A new cause of juvenile parkinsonism. J Neurol 2009; 256: 104-108.
7. Guidubaldi A, Piano C, Santorelli FM etal. Novel mutations in SPG11 cause hereditary spastic paraplegia associated with early-onset levodopa-responsive Parkinsonism. Mov Disord 2011; 26: 553-556.
8. Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross CA, Takahashi H. Synphilin-1 is present in Lewy bodies in Parkinson's disease. Ann Neurol 2000; 47: 521-523.
9. Schlossmacher MG, Frosch MP, Gai WP etal. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol 2002; 160: 1655-1667.
10. Bandopadhyay R, Kingsbury AE, Muqit MM etal. Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. Neurobiol Dis 2005; 20: 401-411.
11. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. α-synuclein in Lewy bodies. Nature 1997; 388: 839-840.
12. Baba M, Nakajo S, Tu PH etal. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998; 152: 879-884.
13. Fujiwara H, Hasegawa M, Dohmae N etal. α-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002; 4: 160-164.
14. Wakabayashi K, Tanji K, Mori F, Takahashi H. The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of α-synuclein aggregates. Neuropathology 2007; 27: 494-506.
15. Matsuoka S, Ballif BA, Smogorzewska A etal. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316: 1160-1166.
16. Camins A, Pizarro JG, Alvira D, Gutierrez-Cuesta J etal. Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease. Cell Mol Life Sci 2010; 67: 3865-3882.
17. Jordan-Sciutto KL, Dorsey R, Chalovich EM, Hammond RR, Achim CL. Expression patterns of retinoblastoma protein in Parkinson disease. J Neuropathol Exp Neurol 2003; 62: 68-74.