메뉴 건너뛰기




Volumn , Issue 8 JAN, 2014, Pages

The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats

Author keywords

Cognitive impairment; EEG; Hypnotics; Hypocretins orexins; Memory impairment; Spatial reference memory; Spatial working memory; Water maze

Indexed keywords

ALMOREXANT; OREXIN RECEPTOR; ZOLPIDEM;

EID: 84898042558     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2014.00003     Document Type: Article
Times cited : (33)

References (52)
  • 1
    • 0026544616 scopus 로고
    • Comparison of the daytime sleep and performance effects of zolpidem versus triazolam
    • doi: 10.1007/BF02244970
    • Balkin, T. J., O'Donnell, V. M., Wesensten, N., McCann, U., and Belenky, G. (1992). Comparison of the daytime sleep and performance effects of zolpidem versus triazolam. Psychopharmacology 107, 83-88. doi: 10.1007/BF02244970.
    • (1992) Psychopharmacology , vol.107 , pp. 83-88
    • Balkin, T.J.1    O'Donnell, V.M.2    Wesensten, N.3    McCann, U.4    Belenky, G.5
  • 2
    • 0037338207 scopus 로고    scopus 로고
    • Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study
    • doi: 10.1046/j.1365-2869.2003.00337.x
    • Belenky, G., Wesensten, N. J., Thorne, D. R., Thomas, M. L., Sing, H. C., Redmond, D. P., et al. (2003). Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J. Sleep Res. 12, 1-12. doi: 10.1046/j.1365-2869.2003.00337.x.
    • (2003) J. Sleep Res , vol.12 , pp. 1-12
    • Belenky, G.1    Wesensten, N.J.2    Thorne, D.R.3    Thomas, M.L.4    Sing, H.C.5    Redmond, D.P.6
  • 3
    • 84885618102 scopus 로고    scopus 로고
    • Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia
    • doi: 10.1021/jm4007627
    • Betschart, C., Hintermann, S., Behnke, D., Cotesta, S., Fendt, M., Gee, C. E., et al. (2013). Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J. Med. Chem. 56, 7590-7607. doi: 10.1021/jm4007627.
    • (2013) J. Med. Chem , vol.56 , pp. 7590-7607
    • Betschart, C.1    Hintermann, S.2    Behnke, D.3    Cotesta, S.4    Fendt, M.5    Gee, C.E.6
  • 4
    • 33846979755 scopus 로고    scopus 로고
    • Promotion of sleep by targeting the orexin system in rats, dogs and humans
    • doi: 10.1038/nm1544
    • Brisbare-Roch, C., Dingemanse, J., Koberstein, R., Hoever, P., Aissaoui, H., Flores, S., et al. (2007). Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat. Med. 13, 150-155. doi: 10.1038/nm1544.
    • (2007) Nat. Med , vol.13 , pp. 150-155
    • Brisbare-Roch, C.1    Dingemanse, J.2    Koberstein, R.3    Hoever, P.4    Aissaoui, H.5    Flores, S.6
  • 5
    • 84857757413 scopus 로고    scopus 로고
    • Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties
    • 337. doi: 10.1002/cmdc.201200025
    • Coleman, P. J., Schreier, J. D., Cox, C. D., Breslin, M. J., Whitman, D. B., Bogusky, M. J., et al. (2012). Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. ChemMedChem 7, 415-424, 337. doi: 10.1002/cmdc.201200025.
    • (2012) ChemMedChem , vol.7 , pp. 415-424
    • Coleman, P.J.1    Schreier, J.D.2    Cox, C.D.3    Breslin, M.J.4    Whitman, D.B.5    Bogusky, M.J.6
  • 6
    • 84863858904 scopus 로고    scopus 로고
    • Hypocretins and the neurobiology of sleep-wake mechanisms
    • doi: 10.1016/B978-0-444-59489-1.00003-3
    • de Lecea, L. (2012). Hypocretins and the neurobiology of sleep-wake mechanisms. Prog. Brain Res. 198, 15-24. doi: 10.1016/B978-0-444-59489-1.00003-3.
    • (2012) Prog. Brain Res , vol.198 , pp. 15-24
    • de Lecea, L.1
  • 8
    • 77957368747 scopus 로고    scopus 로고
    • Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant
    • doi: 10.1007/s00213-010-1933-5
    • Dietrich, H., and Jenck, F. (2010). Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant. Psychopharmacology 212, 145-154. doi: 10.1007/s00213-010-1933-5.
    • (2010) Psychopharmacology , vol.212 , pp. 145-154
    • Dietrich, H.1    Jenck, F.2
  • 9
    • 55949132650 scopus 로고    scopus 로고
    • Hypnosedative-induced complex behaviours: incidence, mechanisms and management
    • doi: 10.2165/0023210-200822120-00005
    • Dolder, C. R., and Nelson, M. H. (2008). Hypnosedative-induced complex behaviours: incidence, mechanisms and management. CNS Drugs 22, 1021-1036. doi: 10.2165/0023210-200822120-00005.
    • (2008) CNS Drugs , vol.22 , pp. 1021-1036
    • Dolder, C.R.1    Nelson, M.H.2
  • 10
    • 67649867893 scopus 로고    scopus 로고
    • Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat
    • doi: 10.1124/jpet.109.152009
    • Dugovic, C., Shelton, J. E., Aluisio, L. E., Fraser, I. C., Jiang, X., Sutton, S. W., et al. (2009). Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J. Pharmacol. Exp. Ther. 330, 142-151. doi: 10.1124/jpet.109.152009.
    • (2009) J. Pharmacol. Exp. Ther , vol.330 , pp. 142-151
    • Dugovic, C.1    Shelton, J.E.2    Aluisio, L.E.3    Fraser, I.C.4    Jiang, X.5    Sutton, S.W.6
  • 11
    • 84858827822 scopus 로고    scopus 로고
    • Zolpidem for insomnia
    • doi: 10.1517/14656566.2012.667074
    • Greenblatt, D. J., and Roth, T. (2012). Zolpidem for insomnia. Expert Opin. Pharmacother. 13, 879-893. doi: 10.1517/14656566.2012.667074.
    • (2012) Expert Opin. Pharmacother , vol.13 , pp. 879-893
    • Greenblatt, D.J.1    Roth, T.2
  • 12
    • 84878108007 scopus 로고    scopus 로고
    • In the Zzz zone: the effects of z-drugs on human performance and driving
    • doi: 10.1007/s13181-013-0294-y
    • Gunja, N. (2013). In the Zzz zone: the effects of z-drugs on human performance and driving. J. Med. Toxicol. 9, 163-171. doi: 10.1007/s13181-013-0294-y.
    • (2013) J. Med. Toxicol , vol.9 , pp. 163-171
    • Gunja, N.1
  • 13
    • 84871323368 scopus 로고    scopus 로고
    • Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant
    • doi: 10.1212/WNL.0b013e31827688ee
    • Herring, W. J., Snyder, E., Budd, K., Hutzelmann, J., Snavely, D., Liu, K., et al. (2012). Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant. Neurology 79, 2265-2274. doi: 10.1212/WNL.0b013e31827688ee.
    • (2012) Neurology , vol.79 , pp. 2265-2274
    • Herring, W.J.1    Snyder, E.2    Budd, K.3    Hutzelmann, J.4    Snavely, D.5    Liu, K.6
  • 14
    • 77951497654 scopus 로고    scopus 로고
    • Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant
    • doi: 10.1038/clpt.2010.19
    • Hoever, P., de Haas, S., Winkler, J., Schoemaker, R. C., Chiossi, E., van Gerven, J., and Dingemanse, J. (2010). Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant. Clin. Pharmacol. Ther. 87, 593-600. doi: 10.1038/clpt.2010.19.
    • (2010) Clin. Pharmacol. Ther , vol.87 , pp. 593-600
    • Hoever, P.1    de Haas, S.2    Winkler, J.3    Schoemaker, R.C.4    Chiossi, E.5    van Gerven, J.6    Dingemanse, J.7
  • 15
    • 84864144743 scopus 로고    scopus 로고
    • Orexin receptor antagonism: an ascending multiple-dose study with almorexant
    • doi: 10.1177/0269881112448946
    • Hoever, P., de Haas, S. L., Dorffner, G., Chiossi, E., van Gerven, J. M., and Dingemanse, J. (2012a). Orexin receptor antagonism: an ascending multiple-dose study with almorexant. J. Psychopharmacol. 26, 1071-1080. doi: 10.1177/0269881112448946.
    • (2012) J. Psychopharmacol. , vol.26 , pp. 1071-1080
    • Hoever, P.1    de Haas, S.L.2    Dorffner, G.3    Chiossi, E.4    van Gerven, J.M.5    Dingemanse, J.6
  • 16
    • 84861342704 scopus 로고    scopus 로고
    • Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial
    • doi: 10.1038/clpt.2011.370
    • Hoever, P., Dorffner, G., Benes, H., Penzel, T., Danker-Hopfe, H., Barbanoj, M. J., et al. (2012b). Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial. Clin. Pharmacol. Ther. 91, 975-985. doi: 10.1038/clpt.2011.370.
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 975-985
    • Hoever, P.1    Dorffner, G.2    Benes, H.3    Penzel, T.4    Danker-Hopfe, H.5    Barbanoj, M.J.6
  • 17
    • 77949571089 scopus 로고    scopus 로고
    • Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in rats
    • doi: 10.1016/j.bbr.2010.02.018
    • Huang, M. P., Radadia, K., Macone, B. W., Auerbach, S. H., and Datta, S. (2010). Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in rats. Behav. Brain Res. 210, 54-66. doi: 10.1016/j.bbr.2010.02.018.
    • (2010) Behav. Brain Res , vol.210 , pp. 54-66
    • Huang, M.P.1    Radadia, K.2    Macone, B.W.3    Auerbach, S.H.4    Datta, S.5
  • 18
    • 84877151653 scopus 로고    scopus 로고
    • The regulation of sleep and wakefulness by the hypothalamic neuropeptide orexin/hypocretin
    • Inutsuka, A., and Yamanaka, A. (2013). The regulation of sleep and wakefulness by the hypothalamic neuropeptide orexin/hypocretin. Nagoya J. Med. Sci. 75, 29-36.
    • (2013) Nagoya J. Med. Sci. , vol.75 , pp. 29-36
    • Inutsuka, A.1    Yamanaka, A.2
  • 19
    • 33847049745 scopus 로고    scopus 로고
    • The dynamics of neurobehavioural recovery following sleep loss
    • doi: 10.1111/j.1365-2869.2007.00574.x
    • Lamond, N., Jay, S. M., Dorrian, J., Ferguson, S. A., Jones, C., and Dawson, D. (2007). The dynamics of neurobehavioural recovery following sleep loss. J. Sleep Res. 16, 33-41. doi: 10.1111/j.1365-2869.2007.00574.x.
    • (2007) J. Sleep Res , vol.16 , pp. 33-41
    • Lamond, N.1    Jay, S.M.2    Dorrian, J.3    Ferguson, S.A.4    Jones, C.5    Dawson, D.6
  • 20
    • 64749098159 scopus 로고    scopus 로고
    • Insomnia: prevalence, impact, pathogenesis, differential diagnosis, and evaluation
    • doi: 10.1016/j.jsmc.2008.02.001
    • Mai, E., and Buysse, D. J. (2008). Insomnia: prevalence, impact, pathogenesis, differential diagnosis, and evaluation. Sleep Med. Clin. 3, 167-174. doi: 10.1016/j.jsmc.2008.02.001.
    • (2008) Sleep Med. Clin , vol.3 , pp. 167-174
    • Mai, E.1    Buysse, D.J.2
  • 21
    • 84873421746 scopus 로고    scopus 로고
    • Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys
    • doi: 10.1016/j.pbb.2012.12.018
    • Makaron, L., Moran, C. A., Namjoshi, O., Rallapalli, S., Cook, J. M., and Rowlett, J. K. (2013). Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys. Pharmacol. Biochem. Behav. 104, 62-68. doi: 10.1016/j.pbb.2012.12.018.
    • (2013) Pharmacol. Biochem. Behav , vol.104 , pp. 62-68
    • Makaron, L.1    Moran, C.A.2    Namjoshi, O.3    Rallapalli, S.4    Cook, J.M.5    Rowlett, J.K.6
  • 22
    • 0035908286 scopus 로고    scopus 로고
    • Differential expression of orexin receptors 1 and 2 in the rat brain
    • doi: 10.1002/cne.1190
    • Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., et al. (2001). Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435, 6-25. doi: 10.1002/cne.1190.
    • (2001) J. Comp. Neurol , vol.435 , pp. 6-25
    • Marcus, J.N.1    Aschkenasi, C.J.2    Lee, C.E.3    Chemelli, R.M.4    Saper, C.B.5    Yanagisawa, M.6
  • 23
    • 0032052683 scopus 로고    scopus 로고
    • Effects of alcohol, zolpidem, and some other sedatives and hypnotics on human performance and memory
    • doi: 10.1016/S0091-3057(97)00506-6
    • Mattila, M. J., Vanakoski, J., Kalska, H., and Seppala, T. (1998). Effects of alcohol, zolpidem, and some other sedatives and hypnotics on human performance and memory. Pharmacol. Biochem. Behav. 59, 917-923. doi: 10.1016/S0091-3057(97)00506-6.
    • (1998) Pharmacol. Biochem. Behav , vol.59 , pp. 917-923
    • Mattila, M.J.1    Vanakoski, J.2    Kalska, H.3    Seppala, T.4
  • 24
    • 84876932335 scopus 로고    scopus 로고
    • Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status
    • doi: 10.1007/s40263-012-0036-8
    • Mieda, M., and Sakurai, T. (2013). Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status. CNS Drugs 27, 83-90. doi: 10.1007/s40263-012-0036-8.
    • (2013) CNS Drugs , vol.27 , pp. 83-90
    • Mieda, M.1    Sakurai, T.2
  • 25
    • 84858708930 scopus 로고    scopus 로고
    • The role of alpha1 and alpha5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats
    • doi: 10.1097/FBP.0b013e3283512c85
    • Milic, M., Divljakovic, J., Rallapalli, S., van Linn, M. L., Timic, T., Cook, J. M., et al. (2012). The role of alpha1 and alpha5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. Behav. Pharmacol. 23, 191-197. doi: 10.1097/FBP.0b013e3283512c85.
    • (2012) Behav. Pharmacol , vol.23 , pp. 191-197
    • Milic, M.1    Divljakovic, J.2    Rallapalli, S.3    van Linn, M.L.4    Timic, T.5    Cook, J.M.6
  • 26
    • 0033054760 scopus 로고    scopus 로고
    • Selective effects of zolpidem on human memory functions
    • doi: 10.1177/026988119901300103
    • Mintzer, M. Z., and Griffiths, R. R. (1999). Selective effects of zolpidem on human memory functions. J. Psychopharmacol. 13, 18-131. doi: 10.1177/026988119901300103.
    • (1999) J. Psychopharmacol , vol.13 , pp. 18-131
    • Mintzer, M.Z.1    Griffiths, R.R.2
  • 27
    • 37549004746 scopus 로고    scopus 로고
    • Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats
    • Morairty, S. R., Hedley, L., Flores, J., Martin, R., and Kilduff, T. S. (2008). Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. Sleep 31, 34-44.
    • (2008) Sleep , vol.31 , pp. 34-44
    • Morairty, S.R.1    Hedley, L.2    Flores, J.3    Martin, R.4    Kilduff, T.S.5
  • 28
    • 84863614156 scopus 로고    scopus 로고
    • Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone
    • doi: 10.1371/journal.pone.0039131
    • Morairty, S. R., Revel, F. G., Malherbe, P., Moreau, J. L., Valladao, D., Wettstein, J. G., et al. (2012). Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone. PLoS ONE 7:e39131. doi: 10.1371/journal.pone.0039131.
    • (2012) PLoS ONE , vol.7
    • Morairty, S.R.1    Revel, F.G.2    Malherbe, P.3    Moreau, J.L.4    Valladao, D.5    Wettstein, J.G.6
  • 29
    • 77950667961 scopus 로고    scopus 로고
    • Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans
    • doi: 10.1111/j.1365-2869.2009.00757.x
    • Morgan, P. T., Kehne, J. H., Sprenger, K. J. and Malison, R. T. (2010). Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans. J. Sleep Res. 19, 157-164. doi: 10.1111/j.1365-2869.2009.00757.x.
    • (2010) J. Sleep Res , vol.19 , pp. 157-164
    • Morgan, P.T.1    Kehne, J.H.2    Sprenger, K.J.3    Malison, R.T.4
  • 30
    • 24644494605 scopus 로고    scopus 로고
    • National Institutes of Health State of the Science Conference statement on Manifestations and Management of Chronic Insomnia in Adults
    • NIH
    • NIH. (2005). National Institutes of Health State of the Science Conference statement on Manifestations and Management of Chronic Insomnia in Adults. Sleep 28, 1049-57.
    • (2005) Sleep , vol.28 , pp. 1049-1057
  • 31
    • 52949138639 scopus 로고    scopus 로고
    • Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers
    • doi: 10.1002/hup.980
    • Otmani, S., Demazieres, A., Staner, C., Jacob, N., Nir, T., Zisapel, N., et al. (2008). Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers. Hum. Psychopharmacol. 23, 693-705. doi: 10.1002/hup.980.
    • (2008) Hum. Psychopharmacol , vol.23 , pp. 693-705
    • Otmani, S.1    Demazieres, A.2    Staner, C.3    Jacob, N.4    Nir, T.5    Zisapel, N.6
  • 33
    • 84868195010 scopus 로고    scopus 로고
    • Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics
    • doi: 10.1016/j.biopsych.2012.05.014
    • Revel, F. G., Moreau, J. L., Gainetdinov, R. R., Ferragud, A., Velazquez-Sanchez, C., Sotnikova, T. D., et al. (2012). Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol. Psychiatry 72, 934-942. doi: 10.1016/j.biopsych.2012.05.014.
    • (2012) Biol. Psychiatry , vol.72 , pp. 934-942
    • Revel, F.G.1    Moreau, J.L.2    Gainetdinov, R.R.3    Ferragud, A.4    Velazquez-Sanchez, C.5    Sotnikova, T.D.6
  • 34
    • 84876681068 scopus 로고    scopus 로고
    • A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic-and antidepressant-like activity, improve cognition and control body weight
    • doi: 10.1038/mp.2012.57
    • Revel, F. G., Moreau, J. L., Pouzet, B., Mory, R., Bradaia, A., Buchy, D., et al. (2013). A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic-and antidepressant-like activity, improve cognition and control body weight. Mol. Psychiatry 18, 543-556. doi: 10.1038/mp.2012.57.
    • (2013) Mol. Psychiatry , vol.18 , pp. 543-556
    • Revel, F.G.1    Moreau, J.L.2    Pouzet, B.3    Mory, R.4    Bradaia, A.5    Buchy, D.6
  • 35
    • 34548487159 scopus 로고    scopus 로고
    • Insomnia: definition, prevalence, etiology, and consequences
    • Roth, T. (2007). Insomnia: definition, prevalence, etiology, and consequences. J. Clin. Sleep Med. 3, S7-S10.
    • (2007) J. Clin. Sleep Med. , vol.3
    • Roth, T.1
  • 36
    • 84873668797 scopus 로고    scopus 로고
    • The neurobiology of sleep
    • doi: 10.1212/01.CON.0000427215.07715.73
    • Saper, C. B. (2013). The neurobiology of sleep. Continuum (Minneap Minn) 19, 19-31. doi: 10.1212/01.CON.0000427215.07715.73.
    • (2013) Continuum (Minneap Minn) , vol.19 , pp. 19-31
    • Saper, C.B.1
  • 37
    • 84884287810 scopus 로고    scopus 로고
    • Allosteric modulation of GABAA receptor subtypes: effects on visual recognition and visuospatial working memory in rhesus monkeys
    • doi: 10.1038/npp.2013.137
    • Soto, P. L., Ator, N. A., Rallapalli, S. K., Biawat, P., Clayton, T., Cook, J. M., et al. (2013). Allosteric modulation of GABAA receptor subtypes: effects on visual recognition and visuospatial working memory in rhesus monkeys. Neuropsychopharmacology 38, 2315-2325. doi: 10.1038/npp.2013.137.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2315-2325
    • Soto, P.L.1    Ator, N.A.2    Rallapalli, S.K.3    Biawat, P.4    Clayton, T.5    Cook, J.M.6
  • 38
    • 79951508286 scopus 로고    scopus 로고
    • Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-alpha1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat
    • doi: 10.1038/npp.2010.224
    • Steiner, M. A., Lecourt, H., Strasser, D. S., Brisbare-Roch, C. and Jenck, F. (2011). Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-alpha1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat. Neuropsychopharmacology 36, 848-856. doi: 10.1038/npp.2010.224.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 848-856
    • Steiner, M.A.1    Lecourt, H.2    Strasser, D.S.3    Brisbare-Roch, C.4    Jenck, F.5
  • 39
    • 33846035369 scopus 로고    scopus 로고
    • Cognitive performance following premature awakening from zolpidem or melatonin induced daytime sleep
    • Storm, W. F., Eddy, D. R., Welch, C. B., Hickey, P. A., Fischer, J., and Cardenas, R. (2007). Cognitive performance following premature awakening from zolpidem or melatonin induced daytime sleep. Aviat. Space Environ. Med. 78, 10-20.
    • (2007) Aviat. Space Environ. Med. , vol.78 , pp. 10-20
    • Storm, W.F.1    Eddy, D.R.2    Welch, C.B.3    Hickey, P.A.4    Fischer, J.5    Cardenas, R.6
  • 40
    • 84876001969 scopus 로고    scopus 로고
    • Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition
    • 179ra44,doi: 10.1126/scitranslmed.3005213
    • Uslaner, J. M., Tye, S. J., Eddins, D. M., Wang, X., Fox, S. V., Savitz, A. T., et al. (2013). Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition. Sci. Transl. Med. 5, 179ra44. doi: 10.1126/scitranslmed.3005213.
    • (2013) Sci. Transl. Med , vol.5
    • Uslaner, J.M.1    Tye, S.J.2    Eddins, D.M.3    Wang, X.4    Fox, S.V.5    Savitz, A.T.6
  • 41
    • 0032749141 scopus 로고    scopus 로고
    • Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids
    • Vanover, K. E., Edgar, D. M., Seidel, W. F., Hogenkamp, D. J., Fick, D. B., Lan, N. C., et al. (1999). Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids. J. Pharmacol. Exp. Ther. 291, 1317-1323.
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 1317-1323
    • Vanover, K.E.1    Edgar, D.M.2    Seidel, W.F.3    Hogenkamp, D.J.4    Fick, D.B.5    Lan, N.C.6
  • 42
    • 35348884060 scopus 로고    scopus 로고
    • Hypnotics and driving safety: meta-analyses of randomized controlled trials applying the on-the-road driving test
    • doi: 10.2174/157488606775252674
    • Verster, J. C., Veldhuijzen, D. S., Patat, A., Olivier, B., and Volkerts, E. R. (2006). Hypnotics and driving safety: meta-analyses of randomized controlled trials applying the on-the-road driving test. Curr. Drug Saf. 1, 63-71. doi: 10.2174/157488606775252674.
    • (2006) Curr. Drug Saf , vol.1 , pp. 63-71
    • Verster, J.C.1    Veldhuijzen, D.S.2    Patat, A.3    Olivier, B.4    Volkerts, E.R.5
  • 43
    • 0036896870 scopus 로고    scopus 로고
    • Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions, and psychomotor performance
    • doi: 10.1097/00004714-200212000-00007
    • Verster, J. C., Volkerts, E. R., Schreuder, A. H., Eijken, E. J., van Heuckelum, J. H., Veldhuijzen, D. S., et al. (2002). Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions, and psychomotor performance. J. Clin. Psychopharmacol. 22, 576-583. doi: 10.1097/00004714-200212000-00007.
    • (2002) J. Clin. Psychopharmacol , vol.22 , pp. 576-583
    • Verster, J.C.1    Volkerts, E.R.2    Schreuder, A.H.3    Eijken, E.J.4    van Heuckelum, J.H.5    Veldhuijzen, D.S.6
  • 44
    • 65749084607 scopus 로고    scopus 로고
    • Experimental sleep fragmentation impairs spatial reference but not working memory in Fischer/Brown Norway rats
    • doi: 10.1111/j.1365-2869.2008.00714.x
    • Ward, C. P., McCarley, R. W., and Strecker, R. E. (2009). Experimental sleep fragmentation impairs spatial reference but not working memory in Fischer/Brown Norway rats. J. Sleep Res. 18, 238-244. doi: 10.1111/j.1365-2869.2008.00714.x.
    • (2009) J. Sleep Res , vol.18 , pp. 238-244
    • Ward, C.P.1    McCarley, R.W.2    Strecker, R.E.3
  • 45
    • 30844471550 scopus 로고    scopus 로고
    • Assessment of spatial memory using the radial arm maze and Morris water maze
    • Chapter 8. Unit 8.5A. doi: 10.1002/0471142301.ns0805as26
    • Wenk, G. L. (2004). Assessment of spatial memory using the radial arm maze and Morris water maze. Curr. Protoc. Neurosci. Chapter 8, Unit 8.5A. doi: 10.1002/0471142301.ns0805as26.
    • (2004) Curr. Protoc. Neurosci.
    • Wenk, G.L.1
  • 46
    • 0033452308 scopus 로고    scopus 로고
    • Does sleep fragmentation impact recuperation? A review and reanalysis
    • doi: 10.1046/j.1365-2869.1999.00161.x
    • Wesensten, N. J., Balkin, T. J., and Belenky, G. (1999). Does sleep fragmentation impact recuperation? A review and reanalysis. J. Sleep Res. 8, 237-245. doi: 10.1046/j.1365-2869.1999.00161.x.
    • (1999) J. Sleep Res , vol.8 , pp. 237-245
    • Wesensten, N.J.1    Balkin, T.J.2    Belenky, G.3
  • 47
    • 0030044849 scopus 로고    scopus 로고
    • Effects of daytime administration of zolpidem and triazolam on performance
    • Wesensten, N. J., Balkin, T. J., and Belenky, G. L. (1996). Effects of daytime administration of zolpidem and triazolam on performance. Aviat. Space Environ. Med. 67, 115-120.
    • (1996) Aviat. Space Environ. Med. , vol.67 , pp. 115-120
    • Wesensten, N.J.1    Balkin, T.J.2    Belenky, G.L.3
  • 49
    • 67749103988 scopus 로고    scopus 로고
    • Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats
    • doi: 10.1002/cmdc.200900069
    • Whitman, D. B., Cox, C. D., Breslin, M. J., Brashear, K. M., Schreier, J. D., Bogusky, M. J., et al. (2009). Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats. ChemMedChem 4, 1069-1074. doi: 10.1002/cmdc.200900069.
    • (2009) ChemMedChem , vol.4 , pp. 1069-1074
    • Whitman, D.B.1    Cox, C.D.2    Breslin, M.J.3    Brashear, K.M.4    Schreier, J.D.5    Bogusky, M.J.6
  • 50
    • 84855982509 scopus 로고    scopus 로고
    • Pharmacological characterization of MK-6096-a dual orexin receptor antagonist for insomnia
    • doi: 10.1016/j.neuropharm.2011.10.003
    • Winrow, C. J., Gotter, A. L., Cox, C. D., Tannenbaum, P. L., Garson, S. L., Doran, S. M., et al. (2012). Pharmacological characterization of MK-6096-a dual orexin receptor antagonist for insomnia. Neuropharmacology 62, 978-987. doi: 10.1016/j.neuropharm.2011.10.003.
    • (2012) Neuropharmacology , vol.62 , pp. 978-987
    • Winrow, C.J.1    Gotter, A.L.2    Cox, C.D.3    Tannenbaum, P.L.4    Garson, S.L.5    Doran, S.M.6
  • 51
    • 48749087488 scopus 로고    scopus 로고
    • Use of computerized dynamic posturography to assess balance in older adults after nighttime awakenings using zolpidem as a reference
    • doi: 10.1186/1471-2318-8-15
    • Zammit, G., Wang-Weigand, S., and Peng, X. (2008). Use of computerized dynamic posturography to assess balance in older adults after nighttime awakenings using zolpidem as a reference. BMC Geriatr. 8:15. doi: 10.1186/1471-2318-8-15.
    • (2008) BMC Geriatr. , vol.8 , pp. 15
    • Zammit, G.1    Wang-Weigand, S.2    Peng, X.3
  • 52
    • 84876475120 scopus 로고    scopus 로고
    • Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task
    • doi: 10.1007/s00213-012-2756-3
    • Zanin, K. A., Patti, C. L., Sanday, L., Fernandes-Santos, L., Oliveira, L. C., Poyares, D., et al. (2013). Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task. Psychopharmacology 226, 459-474. doi: 10.1007/s00213-012-2756-3.
    • (2013) Psychopharmacology , vol.226 , pp. 459-474
    • Zanin, K.A.1    Patti, C.L.2    Sanday, L.3    Fernandes-Santos, L.4    Oliveira, L.C.5    Poyares, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.