Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit

ACS Medicinal Chemistry Letters

Volumn 5, Issue 4, 2014, Pages 373-377

  Jaudzems, Kristaps ^a   Tars, Kaspars ^b   Maurops, Gundars ^a   Ivdra, Natalija ^a   Otikovs, Martins ^a   Leitans, Janis ^b   Kanepe Lapsa, Iveta ^a   Domraceva, Ilona ^a   Mutule, Ilze ^a   Trapencieris, Peteris ^a   Blackman, Michael J ^c   Jirgensons, Aigars ^a  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^b LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Cathepsin D; hydroxyethylamine; inhibition; Malaria; plasmepsins; Plasmodium falciparum; structure guided optimization

Indexed keywords

ANTIMALARIAL AGENT; CATHEPSIN D; PLASMEPSIN I; PLASMEPSIN II; PLASMEPSIN INHIBITOR; PLASMEPSIN IV; UNCLASSIFIED DRUG;

ARTICLE; CELL SCREENING; CELL VACUOLE; CRYSTAL STRUCTURE; DIASTEREOISOMER; DRUG INDUSTRY; ENZYMATIC ASSAY; ERYTHROCYTE; GROWTH INHIBITION; MOLECULAR INTERACTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STEREOISOMERISM;

EID: 84898030031     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml4004952     Document Type: Article

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