Forced degradation studies of corticosteroids with an alumina-steroid-ethanol model for predicting chemical stability and degradation products of pressurized metered-dose inhaler formulations

Journal of Pharmaceutical Sciences

Volumn 101, Issue 6, 2012, Pages 2109-2122

  Wu, Zheng Zhi ^a   Thatcher, Matthew L ^a   Lundberg, James K ^a   Ogawa, Mark K ^a   Jacoby, Cliffton B ^a   Battiste, John L ^a   Ledoux, Katherine A ^a  

^a 3M COMPANY   (United States)

Author keywords

Corticosteroid; Degradation pathway; Degradation reaction; Drug excipient interaction; Drug delivery; Forced degradation; Metered dose inhaler

Indexed keywords

ALCOHOL; ALUMINUM OXIDE; BECLOMETASONE DIPROPIONATE; BUDESONIDE; EXCIPIENT; STEROID; TRIAMCINOLONE ACETONIDE;

AEROSOL; ARTICLE; CHEMICAL INTERACTION; CHEMICAL REACTION; DIASTEREOISOMER; DRUG DEGRADATION; DRUG FORMULATION; DRUG IMPURITY; DRUG PACKAGING; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE; INFRARED SPECTROSCOPY; METERED DOSE INHALER; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PREDICTIVE VALUE; PRESSURE; STRUCTURE ACTIVITY RELATION;

EID: 84859744261     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23111     Document Type: Article

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