Antitumor effect of miR-197 targeting in p53 wild-type lung cancer

Cell Death and Differentiation

Volumn 21, Issue 5, 2014, Pages 774-782

  Fiori, M E ^a,b   Barbini, C ^a   Haas, T L ^a,b   Marroncelli, N ^a   Patrizii, M ^a   Biffoni, M ^a   De Maria, R ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

apoptosis; LNA; lung cancer; microRNAs; p53

Indexed keywords

ANTINEOPLASTIC AGENT; BH3 PROTEIN; CASPASE 3; CASPASE 7; LNA 197; LOCKED NUCLEIC ACID; MICRORNA; MICRORNA 197; PROTEIN BCL 2; PROTEIN NOXA; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; MIRN197 MICRORNA, HUMAN; OLIGONUCLEOTIDE; TP53 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER SURVIVAL; CELL SCREENING; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENETIC SCREENING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; TUMOR XENOGRAFT; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL GROWTH; DRUG SCREENING; GENETICS; GENOMICS; LUNG NEOPLASMS; METABOLISM; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

MUS;

ANIMALS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; FEMALE; GENOMICS; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; MICRORNAS; MOLECULAR TARGETED THERAPY; OLIGONUCLEOTIDES; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898019990     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.6     Document Type: Article

References (39)

1. Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-355. (Pubitemid 39265675)
2. Lujambio A, Lowe SW. The microcosmos of cancer. Nature 2012; 482: 347-355.
3. Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009; 10: 704-714.
4. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med 2008; 359: 1367-1380.
5. Cheng L, Zhang S, Alexander R, Yao Y, MacLennan GT, Pan CX et al. The landscape of EGFR pathways and personalized management of non-small-cell lung cancer. Future Oncol 2011; 7: 519-541.
6. Jemal A, Ma J, Rosenberg PS, Siegel R, Anderson WF. Increasing lung cancer death rates among young women in southern and midwestern States. J Clin Oncol 2012; 30: 2739-2744.
7. Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R. EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary. Eur J Cancer 2009; 45: 931-991.
8. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88: 323-331. (Pubitemid 27131374)
9. He L, He X, Lowe SW, Hannon GJ. microRNAs join the p53 network-another piece in the tumour-suppression puzzle. Nat Rev Cancer 2007; 7: 819-822. (Pubitemid 350006254)
10. Hermeking H. MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer 2012; 12: 613-626.
11. Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007; 26: 745-752. (Pubitemid 46856245)
12. He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y et al. A microRNA component of the p53 tumour suppressor network. Nature 2007; 447: 1130-1134. (Pubitemid 47014436)
13. Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Moskovits N et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 2007; 26: 731-743. (Pubitemid 46856247)
14. Xiao J, Lin H, Luo X, Wang Z. miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J 2011; 30: 524-532.
15. Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. Modulation of microRNA processing by p53. Nature 2009; 460: 529-533.
16. Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V et al. MicroRNA-125b is a novel negative regulator of p53. Genes Dev 2009; 23: 862-876.
17. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006; 9: 189-198. (Pubitemid 43357945)
18. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103: 2257-2261. (Pubitemid 43271657)
19. Du L, Schageman JJ, Subauste MC, Saber B, Hammond SM, Prudkin L et al. miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1. Mol Cancer Res 2009; 7: 1234-1243.
20. Zheng D, Haddadin S, Wang Y, Gu LQ, Perry MC, Freter CE et al. Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol 2011; 4: 575-586.
21. Boeri M, Verri C, Conte D, Roz L, Modena P, Facchinetti F et al. MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proc Natl Acad Sci USA 2011; 108: 3713-3718.
22. Weber F, Teresi RE, Broelsch CE, Frilling A, Eng C. A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma. J Clin Endocrinol Metab 2006; 91: 3584-3591. (Pubitemid 44402141)
23. Nikiforova MN, Tseng GC, Steward D, Diorio D, Nikiforov YE. MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility. J Clin Endocrinol Metab 2008; 93: 1600-1608. (Pubitemid 351656494)
24. Keutgen XM, Filicori F, Crowley MJ, Wang Y, Scognamiglio T, Hoda R et al. A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration. Clin Cancer Res 2012; 18: 2032-2038.
25. Hamada S, Satoh K, Miura S, Hirota M, Kanno A, Masamune A et al. MiR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol 2012; 228: 1255-1263.
26. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
27. Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1-13.
28. Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE et al. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 2001; 293: 1829-1832. (Pubitemid 32845780)
29. Pinon JD, Labi V, Egle A, Villunger A. Bim and Bmf in tissue homeostasis and malignant disease. Oncogene 2008; 27(Suppl 1): S41-S52.
30. Gilkes DM, Chen LH, Chen JD. MDMX regulation of p53 response to ribosomal stress. EMBO J 2006; 25: 5614-5625. (Pubitemid 44847201)
31. Zhou X, Liao JM, Liao WJ, Lu H. Scission of the p53-MDM2 loop by ribosomal proteins. Genes Cancer 2012; 3: 298-310.
32. Macias E, Jin AW, Deisenroth C, Bhat K, Mao H, Lindstrom MS et al. An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 interaction. Cancer Cell 2010; 18: 231-243.
33. Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010; 9: 775-789.
34. Pencheva N, Tran H, Buss C, Huh D, Drobnjak M, Busam K et al. Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell 2012; 151: 1068-1082.
35. Elmen J, Lindow M, Schutz S, Lawrence M, Petri A, Obad S et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008; 452: 896-899. (Pubitemid 351550859)
36. Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010; 327: 198-201.
37. Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010; 464: 1067-1070.
38. Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K et al. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013; 368: 1685-1694.
39. Fontana L, Pelosi E, Greco P, Racanicchi S, Testa U, Liuzzi F et al. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 2007; 9: 775-787. (Pubitemid 47019464)