메뉴 건너뛰기




Volumn 25, Issue 5, 2013, Pages 579-587

Systems approaches to studying the immune response in tuberculosis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; INTERFERON;

EID: 84898018651     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2013.08.003     Document Type: Review
Times cited : (34)

References (58)
  • 2
    • 84875498895 scopus 로고    scopus 로고
    • The immune response in tuberculosis
    • This review provides an overview of our current understanding of the immune response to tuberculosis, in the context of the challenges created by its complex epidemiology and varied clinical presentations.
    • 2•• O'Garra, A., Redford, P.S., McNab, F.W., Bloom, C.I., Wilkinson, R.J., Berry, M.P., The immune response in tuberculosis. Annu Rev Immunol 31 (2013), 475–527 This review provides an overview of our current understanding of the immune response to tuberculosis, in the context of the challenges created by its complex epidemiology and varied clinical presentations.
    • (2013) Annu Rev Immunol , vol.31 , pp. 475-527
    • O'Garra, A.1    Redford, P.S.2    McNab, F.W.3    Bloom, C.I.4    Wilkinson, R.J.5    Berry, M.P.6
  • 4
    • 79960584784 scopus 로고    scopus 로고
    • High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB scrseening
    • 4 Oni, T., Burke, R., Tsekela, R., Bangani, N., Seldon, R., Gideon, H.P., Wood, K., Wilkinson, K.A., Ottenhoff, T.H., Wilkinson, R.J., High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB scrseening. Thorax 66 (2011), 669–673.
    • (2011) Thorax , vol.66 , pp. 669-673
    • Oni, T.1    Burke, R.2    Tsekela, R.3    Bangani, N.4    Seldon, R.5    Gideon, H.P.6    Wood, K.7    Wilkinson, K.A.8    Ottenhoff, T.H.9    Wilkinson, R.J.10
  • 5
    • 68149098007 scopus 로고    scopus 로고
    • Overcoming the global crisis: “yes, we can”, but also for TB…?
    • 5 Ottenhoff, T.H., Overcoming the global crisis: “yes, we can”, but also for TB…?. Eur J Immunol 39 (2009), 2014–2020.
    • (2009) Eur J Immunol , vol.39 , pp. 2014-2020
    • Ottenhoff, T.H.1
  • 6
    • 84875382846 scopus 로고    scopus 로고
    • Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
    • This paper describes the first human infant efficacy trial of a new TB vaccine candidate since BCG, and represents a landmark step in the quest to develop new vaccines.
    • 6•• Tameris, M.D., Hatherill, M., Landry, B.S., Scriba, T.J., Snowden, M.A., Lockhart, S., Shea, J.E., McClain, J.B., Hussey, G.D., Hanekom, W.A., et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet, 2013 This paper describes the first human infant efficacy trial of a new TB vaccine candidate since BCG, and represents a landmark step in the quest to develop new vaccines.
    • (2013) Lancet
    • Tameris, M.D.1    Hatherill, M.2    Landry, B.S.3    Scriba, T.J.4    Snowden, M.A.5    Lockhart, S.6    Shea, J.E.7    McClain, J.B.8    Hussey, G.D.9    Hanekom, W.A.10
  • 7
    • 84875868248 scopus 로고    scopus 로고
    • Vaccination against tuberculosis: How can we better BCG?
    • 7 Pitt, J.M., Blankley, S., McShane, H., O'Garra, A., Vaccination against tuberculosis: How can we better BCG?. Microb Pathog 58 (2013), 2–16.
    • (2013) Microb Pathog , vol.58 , pp. 2-16
    • Pitt, J.M.1    Blankley, S.2    McShane, H.3    O'Garra, A.4
  • 8
    • 79951676291 scopus 로고    scopus 로고
    • Systems biology approaches to dissect mammalian innate immunity
    • 8 Shapira, S.D., Hacohen, N., Systems biology approaches to dissect mammalian innate immunity. Curr Opin Immunol 23 (2010), 71–77.
    • (2010) Curr Opin Immunol , vol.23 , pp. 71-77
    • Shapira, S.D.1    Hacohen, N.2
  • 10
    • 84856727590 scopus 로고    scopus 로고
    • Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets
    • 10 Mukhopadhyay, S., Nair, S., Ghosh, S., Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets. FEMS Microbiol Rev 36 (2012), 463–485.
    • (2012) FEMS Microbiol Rev , vol.36 , pp. 463-485
    • Mukhopadhyay, S.1    Nair, S.2    Ghosh, S.3
  • 11
    • 80053265890 scopus 로고    scopus 로고
    • A role for systems epidemiology in tuberculosis research
    • 11 Comas, I., Gagneux, S., A role for systems epidemiology in tuberculosis research. Trends Microbiol 19 (2011), 492–500.
    • (2011) Trends Microbiol , vol.19 , pp. 492-500
    • Comas, I.1    Gagneux, S.2
  • 15
    • 84864612118 scopus 로고    scopus 로고
    • Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients
    • This study provides proof of principle for metabolomic profiling and highlights a role for tryptophan metabolism in the immune response to TB, consistent with earlier reports in animal models and from gene expression studies.
    • 15• Weiner, J. 3rd, Parida, S.K., Maertzdorf, J., Black, G.F., Repsilber, D., Telaar, A., Mohney, R.P., Arndt-Sullivan, C., Ganoza, C.A., Fae, K.C., et al. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PLoS One, 7, 2012, e40221 This study provides proof of principle for metabolomic profiling and highlights a role for tryptophan metabolism in the immune response to TB, consistent with earlier reports in animal models and from gene expression studies.
    • (2012) PLoS One , vol.7 , pp. e40221
    • Weiner, J.1    Parida, S.K.2    Maertzdorf, J.3    Black, G.F.4    Repsilber, D.5    Telaar, A.6    Mohney, R.P.7    Arndt-Sullivan, C.8    Ganoza, C.A.9    Fae, K.C.10
  • 17
    • 58249103970 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host
    • 17 Zelante, T., Fallarino, F., Bistoni, F., Puccetti, P., Romani, L., Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host. Microbes Infect 11 (2009), 133–141.
    • (2009) Microbes Infect , vol.11 , pp. 133-141
    • Zelante, T.1    Fallarino, F.2    Bistoni, F.3    Puccetti, P.4    Romani, L.5
  • 18
    • 0037245343 scopus 로고    scopus 로고
    • Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification
    • 18 Simon, R., Radmacher, M.D., Dobbin, K., McShane, L.M., Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification. J Natl Cancer Inst 95 (2003), 14–18.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 14-18
    • Simon, R.1    Radmacher, M.D.2    Dobbin, K.3    McShane, L.M.4
  • 19
    • 77954384233 scopus 로고    scopus 로고
    • Assessing the human immune system through blood transcriptomics
    • 19 Chaussabel, D., Pascual, V., Banchereau, J., Assessing the human immune system through blood transcriptomics. BMC Biol, 8, 2010, 84.
    • (2010) BMC Biol , vol.8 , pp. 84
    • Chaussabel, D.1    Pascual, V.2    Banchereau, J.3
  • 20
    • 81555216077 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: classification, prognostication, and prediction
    • 20 Reis-Filho, J.S., Pusztai, L., Gene expression profiling in breast cancer: classification, prognostication, and prediction. Lancet 378 (2012), 1812–1823.
    • (2012) Lancet , vol.378 , pp. 1812-1823
    • Reis-Filho, J.S.1    Pusztai, L.2
  • 21
    • 77952318708 scopus 로고    scopus 로고
    • A genomic approach to human autoimmune diseases
    • 21 Pascual, V., Chaussabel, D., Banchereau, J., A genomic approach to human autoimmune diseases. Annu Rev Immunol 28 (2010), 535–571.
    • (2010) Annu Rev Immunol , vol.28 , pp. 535-571
    • Pascual, V.1    Chaussabel, D.2    Banchereau, J.3
  • 24
    • 33746901578 scopus 로고    scopus 로고
    • Microarray analysis of gene expression associated with extrapulmonary dissemination of tuberculosis
    • 24 Kim, D.K., Park, G.M., Hwang, Y.I., Kim, H.J., Han, S.K., Shim, Y.S., Yim, J.J., Microarray analysis of gene expression associated with extrapulmonary dissemination of tuberculosis. Respirology 11 (2006), 557–565.
    • (2006) Respirology , vol.11 , pp. 557-565
    • Kim, D.K.1    Park, G.M.2    Hwang, Y.I.3    Kim, H.J.4    Han, S.K.5    Shim, Y.S.6    Yim, J.J.7
  • 25
    • 77955894773 scopus 로고    scopus 로고
    • An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    • This manuscript was the first to describe a blood transcriptional profile of active tuberculosis that was absent in latent disease, demonstrating an interferon-inducible signature of active tuberculosis which correlated with the extent of lung radiographic disease and was diminished upon treatment.
    • 25•• Berry, M.P., Graham, C.M., McNab, F.W., Xu, Z., Bloch, S.A., Oni, T., Wilkinson, K.A., Banchereau, R., Skinner, J., Wilkinson, R.J., et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466 (2010), 973–977 This manuscript was the first to describe a blood transcriptional profile of active tuberculosis that was absent in latent disease, demonstrating an interferon-inducible signature of active tuberculosis which correlated with the extent of lung radiographic disease and was diminished upon treatment.
    • (2010) Nature , vol.466 , pp. 973-977
    • Berry, M.P.1    Graham, C.M.2    McNab, F.W.3    Xu, Z.4    Bloch, S.A.5    Oni, T.6    Wilkinson, K.A.7    Banchereau, R.8    Skinner, J.9    Wilkinson, R.J.10
  • 27
    • 80055042377 scopus 로고    scopus 로고
    • Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis
    • This study confirms the reproducibility of the characteristic interferon-inducible blood transcriptional signature of human TB, validating earlier findings despite the use of different microarray platforms, blood collection and processing.
    • 27•• Maertzdorf, J., Ota, M., Repsilber, D., Mollenkopf, H.J., Weiner, J., Hill, P.C., Kaufmann, S.H., Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis. PLoS One, 6, 2011, e26938 This study confirms the reproducibility of the characteristic interferon-inducible blood transcriptional signature of human TB, validating earlier findings despite the use of different microarray platforms, blood collection and processing.
    • (2011) PLoS One , vol.6 , pp. e26938
    • Maertzdorf, J.1    Ota, M.2    Repsilber, D.3    Mollenkopf, H.J.4    Weiner, J.5    Hill, P.C.6    Kaufmann, S.H.7
  • 29
    • 84866686896 scopus 로고    scopus 로고
    • Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis
    • This study also validates the characteristic interferon-inducible blood transcriptional signature in human TB, but also importantly identifies common interferon-inducible responses in the lungs of infected mice and in infected human macrophages.
    • 29•• Ottenhoff, T.H., Dass, R.H., Yang, N., Zhang, M.M., Wong, H.E., Sahiratmadja, E., Khor, C.C., Alisjahbana, B., van Crevel, R., Marzuki, S., et al. Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis. PLoS One, 7, 2012, e45839 This study also validates the characteristic interferon-inducible blood transcriptional signature in human TB, but also importantly identifies common interferon-inducible responses in the lungs of infected mice and in infected human macrophages.
    • (2012) PLoS One , vol.7 , pp. e45839
    • Ottenhoff, T.H.1    Dass, R.H.2    Yang, N.3    Zhang, M.M.4    Wong, H.E.5    Sahiratmadja, E.6    Khor, C.C.7    Alisjahbana, B.8    van Crevel, R.9    Marzuki, S.10
  • 30
    • 84861035952 scopus 로고    scopus 로고
    • Common patterns and disease-related signatures in tuberculosis and sarcoidosis
    • This study is the first to perform a direct comparison of blood transcriptional profiles from patients with TB and Sarcoidosis and to identify common and distinct signatures.
    • 30•• Maertzdorf, J., Weiner, J. 3rd, Mollenkopf, H.J., Bauer, T., Prasse, A., Muller-Quernheim, J., Kaufmann, S.H., Common patterns and disease-related signatures in tuberculosis and sarcoidosis. Proc Natl Acad Sci U S A 109 (2012), 7853–7858 This study is the first to perform a direct comparison of blood transcriptional profiles from patients with TB and Sarcoidosis and to identify common and distinct signatures.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 7853-7858
    • Maertzdorf, J.1    Weiner, J.2    Mollenkopf, H.J.3    Bauer, T.4    Prasse, A.5    Muller-Quernheim, J.6    Kaufmann, S.H.7
  • 32
    • 0038342438 scopus 로고    scopus 로고
    • Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
    • 32 Chaussabel, D., Semnani, R.T., McDowell, M.A., Sacks, D., Sher, A., Nutman, T.B., Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood 102 (2003), 672–681.
    • (2003) Blood , vol.102 , pp. 672-681
    • Chaussabel, D.1    Semnani, R.T.2    McDowell, M.A.3    Sacks, D.4    Sher, A.5    Nutman, T.B.6
  • 33
  • 34
    • 84861868603 scopus 로고    scopus 로고
    • An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection
    • 34 Wu, K., Dong, D., Fang, H., Levillain, F., Jin, W., Mei, J., Gicquel, B., Du, Y., Wang, K., Gao, Q., et al. An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection. PLoS One, 7, 2012, e38367.
    • (2012) PLoS One , vol.7 , pp. e38367
    • Wu, K.1    Dong, D.2    Fang, H.3    Levillain, F.4    Jin, W.5    Mei, J.6    Gicquel, B.7    Du, Y.8    Wang, K.9    Gao, Q.10
  • 35
    • 0036259829 scopus 로고    scopus 로고
    • Alpha/beta interferon impairs the ability of human macrophages to control growth of Mycobacterium bovis BCG
    • 35 Bouchonnet, F., Boechat, N., Bonay, M., Hance, A.J., Alpha/beta interferon impairs the ability of human macrophages to control growth of Mycobacterium bovis BCG. Infect Immun 70 (2002), 3020–3025.
    • (2002) Infect Immun , vol.70 , pp. 3020-3025
    • Bouchonnet, F.1    Boechat, N.2    Bonay, M.3    Hance, A.J.4
  • 36
    • 29444432905 scopus 로고    scopus 로고
    • Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway
    • 36 Manca, C., Tsenova, L., Freeman, S., Barczak, A.K., Tovey, M., Murray, P.J., Barry, C., Kaplan, G., Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res 25 (2005), 694–701.
    • (2005) J Interferon Cytokine Res , vol.25 , pp. 694-701
    • Manca, C.1    Tsenova, L.2    Freeman, S.3    Barczak, A.K.4    Tovey, M.5    Murray, P.J.6    Barry, C.7    Kaplan, G.8
  • 37
    • 33847359299 scopus 로고    scopus 로고
    • The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis
    • 37 Stanley, S.A., Johndrow, J.E., Manzanillo, P., Cox, J.S., The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis. J Immunol 178 (2007), 3143–3152.
    • (2007) J Immunol , vol.178 , pp. 3143-3152
    • Stanley, S.A.1    Johndrow, J.E.2    Manzanillo, P.3    Cox, J.S.4
  • 38
    • 84255162073 scopus 로고    scopus 로고
    • Innate and adaptive interferons suppress IL-1alpha and IL-1beta production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection
    • This study highlights a potentially detrimental role for type I interferons during TB, through suppression of IL-1.
    • 38•• Mayer-Barber, K.D., Andrade, B.B., Barber, D.L., Hieny, S., Feng, C.G., Caspar, P., Oland, S., Gordon, S., Sher, A., Innate and adaptive interferons suppress IL-1alpha and IL-1beta production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity 35 (2011), 1023–1034 This study highlights a potentially detrimental role for type I interferons during TB, through suppression of IL-1.
    • (2011) Immunity , vol.35 , pp. 1023-1034
    • Mayer-Barber, K.D.1    Andrade, B.B.2    Barber, D.L.3    Hieny, S.4    Feng, C.G.5    Caspar, P.6    Oland, S.7    Gordon, S.8    Sher, A.9
  • 39
    • 0034440781 scopus 로고    scopus 로고
    • Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung
    • 39 Cooper, A.M., Pearl, J.E., Brooks, J.V., Ehlers, S., Orme, I.M., Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung. Infect Immun 68 (2000), 6879–6882.
    • (2000) Infect Immun , vol.68 , pp. 6879-6882
    • Cooper, A.M.1    Pearl, J.E.2    Brooks, J.V.3    Ehlers, S.4    Orme, I.M.5
  • 40
    • 33645829064 scopus 로고    scopus 로고
    • Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guerin infection
    • 40 Kuchtey, J., Fulton, S.A., Reba, S.M., Harding, C.V., Boom, W.H., Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guerin infection. Immunology 118 (2006), 39–49.
    • (2006) Immunology , vol.118 , pp. 39-49
    • Kuchtey, J.1    Fulton, S.A.2    Reba, S.M.3    Harding, C.V.4    Boom, W.H.5
  • 41
    • 84875425732 scopus 로고    scopus 로고
    • Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses
    • Through microarray analysis of human tissue, supported by in vitro models and analysis of deposited data, this study suggests that in the mycobacterial disease leprosy, the balance of type I and type II interferons determines protective or susceptible host immune responses.
    • 41•• Teles, R.M., Graeber, T.G., Krutzik, S.R., Montoya, D., Schenk, M., Lee, D.J., Komisopoulou, E., Kelly-Scumpia, K., Chun, R., Iyer, S.S., et al. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science 339 (2013), 1448–1453 Through microarray analysis of human tissue, supported by in vitro models and analysis of deposited data, this study suggests that in the mycobacterial disease leprosy, the balance of type I and type II interferons determines protective or susceptible host immune responses.
    • (2013) Science , vol.339 , pp. 1448-1453
    • Teles, R.M.1    Graeber, T.G.2    Krutzik, S.R.3    Montoya, D.4    Schenk, M.5    Lee, D.J.6    Komisopoulou, E.7    Kelly-Scumpia, K.8    Chun, R.9    Iyer, S.S.10
  • 42
    • 84873023289 scopus 로고    scopus 로고
    • A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children
    • The first blood transcriptional profiling study in human TB to study children, this shows that signatures defined in adults may not be directly applicable to the paediatric population.
    • 42• Verhagen, L.M., Zomer, A., Maes, M., Villalba, J.A., Del Nogal, B., Eleveld, M., van Hijum, S.A., de Waard, J.H., Hermans, P.W., A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children. BMC Genomics, 14, 2013, 74 The first blood transcriptional profiling study in human TB to study children, this shows that signatures defined in adults may not be directly applicable to the paediatric population.
    • (2013) BMC Genomics , vol.14 , pp. 74
    • Verhagen, L.M.1    Zomer, A.2    Maes, M.3    Villalba, J.A.4    Del Nogal, B.5    Eleveld, M.6    van Hijum, S.A.7    de Waard, J.H.8    Hermans, P.W.9
  • 44
    • 33846978784 scopus 로고    scopus 로고
    • Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting
    • 44 Dupuy, A., Simon, R.M., Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting. J Natl Cancer Inst 99 (2007), 147–157.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 147-157
    • Dupuy, A.1    Simon, R.M.2
  • 47
    • 80052313144 scopus 로고    scopus 로고
    • Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells
    • 47 Lu, C., Wu, J., Wang, H., Wang, S., Diao, N., Wang, F., Gao, Y., Chen, J., Shao, L., Weng, X., et al. Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells. PLoS One, 6, 2011, e24290.
    • (2011) PLoS One , vol.6 , pp. e24290
    • Lu, C.1    Wu, J.2    Wang, H.3    Wang, S.4    Diao, N.5    Wang, F.6    Gao, Y.7    Chen, J.8    Shao, L.9    Weng, X.10
  • 48
    • 84867031010 scopus 로고    scopus 로고
    • Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy
    • This study expands on the previous longitudinal data, showing changes in the host response to TB as early as 2 weeks after therapy and demonstrates proof-of-principle that transcriptional profiles could be used for individual treatment monitoring.
    • 48• Bloom, C.I., Graham, C.M., Berry, M.P., Wilkinson, K.A., Oni, T., Rozakeas, F., Xu, Z., Rossello-Urgell, J., Chaussabel, D., Banchereau, J., et al. Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. PLoS One, 7, 2012, e46191 This study expands on the previous longitudinal data, showing changes in the host response to TB as early as 2 weeks after therapy and demonstrates proof-of-principle that transcriptional profiles could be used for individual treatment monitoring.
    • (2012) PLoS One , vol.7 , pp. e46191
    • Bloom, C.I.1    Graham, C.M.2    Berry, M.P.3    Wilkinson, K.A.4    Oni, T.5    Rozakeas, F.6    Xu, Z.7    Rossello-Urgell, J.8    Chaussabel, D.9    Banchereau, J.10
  • 49
    • 77952473253 scopus 로고    scopus 로고
    • Sputum monitoring during tuberculosis treatment for predicting outcome: systematic review and meta-analysis
    • 49 Horne, D.J., Royce, S.E., Gooze, L., Narita, M., Hopewell, P.C., Nahid, P., Steingart, K.R., Sputum monitoring during tuberculosis treatment for predicting outcome: systematic review and meta-analysis. Lancet Infect Dis 10 (2010), 387–394.
    • (2010) Lancet Infect Dis , vol.10 , pp. 387-394
    • Horne, D.J.1    Royce, S.E.2    Gooze, L.3    Narita, M.4    Hopewell, P.C.5    Nahid, P.6    Steingart, K.R.7
  • 50
    • 84872978097 scopus 로고    scopus 로고
    • Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response
    • This study shows that transcriptional responses to TB treatment can occur after only one week and characterizes these early responses as dominated by inflammatory responses reducing, whilst later changes show a restoration of B cell related transcripts.
    • 50• Cliff, J.M., Lee, J.S., Constantinou, N., Cho, J.E., Clark, T.G., Ronacher, K., King, E.C., Lukey, P.T., Duncan, K., Van Helden, P.D., et al. Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response. J Infect Dis 207 (2013), 18–29 This study shows that transcriptional responses to TB treatment can occur after only one week and characterizes these early responses as dominated by inflammatory responses reducing, whilst later changes show a restoration of B cell related transcripts.
    • (2013) J Infect Dis , vol.207 , pp. 18-29
    • Cliff, J.M.1    Lee, J.S.2    Constantinou, N.3    Cho, J.E.4    Clark, T.G.5    Ronacher, K.6    King, E.C.7    Lukey, P.T.8    Duncan, K.9    Van Helden, P.D.10
  • 52
    • 79953274965 scopus 로고    scopus 로고
    • Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages
    • 52 Portevin, D., Gagneux, S., Comas, I., Young, D., Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages. PLoS Pathog, 7, 2011, e1001307.
    • (2011) PLoS Pathog , vol.7 , pp. e1001307
    • Portevin, D.1    Gagneux, S.2    Comas, I.3    Young, D.4
  • 55
    • 42449121424 scopus 로고    scopus 로고
    • Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis
    • 55 Thwaites, G., Caws, M., Chau, T.T., D'Sa, A., Lan, N.T., Huyen, M.N., Gagneux, S., Anh, P.T., Tho, D.Q., Torok, E., et al. Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis. J Clin Microbiol 46 (2008), 1363–1368.
    • (2008) J Clin Microbiol , vol.46 , pp. 1363-1368
    • Thwaites, G.1    Caws, M.2    Chau, T.T.3    D'Sa, A.4    Lan, N.T.5    Huyen, M.N.6    Gagneux, S.7    Anh, P.T.8    Tho, D.Q.9    Torok, E.10
  • 56
    • 79953194081 scopus 로고    scopus 로고
    • Multiscale computational modeling reveals a critical role for TNF-alpha receptor 1 dynamics in tuberculosis granuloma formation
    • 56 Fallahi-Sichani, M., El-Kebir, M., Marino, S., Kirschner, D.E., Linderman, J.J., Multiscale computational modeling reveals a critical role for TNF-alpha receptor 1 dynamics in tuberculosis granuloma formation. J Immunol 186 (2011), 3472–3483.
    • (2011) J Immunol , vol.186 , pp. 3472-3483
    • Fallahi-Sichani, M.1    El-Kebir, M.2    Marino, S.3    Kirschner, D.E.4    Linderman, J.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.