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1
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84870370352
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Global Tuberculosis Report 2012
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World Health Organization Geneva, Switzerland
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1 Floyd, K., Dias, H.M., Falzon, D., Fitzpatrick, C., Glaziou, P., Hiatt, T., Lienhardt, C., Nguyen, L., Sismanidis, C., Timimi, H., et al. Global Tuberculosis Report 2012., 2012, World Health Organization, Geneva, Switzerland.
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2
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84875498895
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The immune response in tuberculosis
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This review provides an overview of our current understanding of the immune response to tuberculosis, in the context of the challenges created by its complex epidemiology and varied clinical presentations.
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2•• O'Garra, A., Redford, P.S., McNab, F.W., Bloom, C.I., Wilkinson, R.J., Berry, M.P., The immune response in tuberculosis. Annu Rev Immunol 31 (2013), 475–527 This review provides an overview of our current understanding of the immune response to tuberculosis, in the context of the challenges created by its complex epidemiology and varied clinical presentations.
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3
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3 Barry, C.E. 3rd, Boshoff, H.I., Dartois, V., Dick, T., Ehrt, S., Flynn, J., Schnappinger, D., Wilkinson, R.J., Young, D., The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat Rev Microbiol 7 (2009), 845–855.
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4
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High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB scrseening
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4 Oni, T., Burke, R., Tsekela, R., Bangani, N., Seldon, R., Gideon, H.P., Wood, K., Wilkinson, K.A., Ottenhoff, T.H., Wilkinson, R.J., High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB scrseening. Thorax 66 (2011), 669–673.
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This paper describes the first human infant efficacy trial of a new TB vaccine candidate since BCG, and represents a landmark step in the quest to develop new vaccines.
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6•• Tameris, M.D., Hatherill, M., Landry, B.S., Scriba, T.J., Snowden, M.A., Lockhart, S., Shea, J.E., McClain, J.B., Hussey, G.D., Hanekom, W.A., et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet, 2013 This paper describes the first human infant efficacy trial of a new TB vaccine candidate since BCG, and represents a landmark step in the quest to develop new vaccines.
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Tameris, M.D.1
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9 Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K., Gas, S., Barry, C.E. 3rd, et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393 (1998), 537–544.
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10 Mukhopadhyay, S., Nair, S., Ghosh, S., Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets. FEMS Microbiol Rev 36 (2012), 463–485.
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11 Comas, I., Gagneux, S., A role for systems epidemiology in tuberculosis research. Trends Microbiol 19 (2011), 492–500.
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12 Sandhu, G., Battaglia, F., Ely, B.K., Athanasakis, D., Montoya, R., Valencia, T., Gilman, R.H., Evans, C.A., Friedland, J.S., Fernandez-Reyes, D., et al. Discriminating active from latent tuberculosis in patients presenting to community clinics. PLoS One, 7, 2012, e38080.
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Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum
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13 Agranoff, D., Fernandez-Reyes, D., Papadopoulos, M.C., Rojas, S.A., Herbster, M., Loosemore, A., Tarelli, E., Sheldon, J., Schwenk, A., Pollok, R., et al. Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum. Lancet 368 (2006), 1012–1021.
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14
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Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment
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14 De Groote, M.A., Nahid, P., Jarlsberg, L., Johnson, J.L., Weiner, M., Muzanyi, G., Janjic, N., Sterling, D.G., Ochsner, U.A., Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment. PLoS One, 8, 2013, e61002.
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15
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84864612118
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Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients
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This study provides proof of principle for metabolomic profiling and highlights a role for tryptophan metabolism in the immune response to TB, consistent with earlier reports in animal models and from gene expression studies.
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15• Weiner, J. 3rd, Parida, S.K., Maertzdorf, J., Black, G.F., Repsilber, D., Telaar, A., Mohney, R.P., Arndt-Sullivan, C., Ganoza, C.A., Fae, K.C., et al. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PLoS One, 7, 2012, e40221 This study provides proof of principle for metabolomic profiling and highlights a role for tryptophan metabolism in the immune response to TB, consistent with earlier reports in animal models and from gene expression studies.
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Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis
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16 Suzuki, Y., Suda, T., Asada, K., Miwa, S., Suzuki, M., Fujie, M., Furuhashi, K., Nakamura, Y., Inui, N., Shirai, T., et al. Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis. Clin Vaccine Immunol 19 (2012), 436–442.
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17 Zelante, T., Fallarino, F., Bistoni, F., Puccetti, P., Romani, L., Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host. Microbes Infect 11 (2009), 133–141.
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22 Jacobsen, M., Repsilber, D., Gutschmidt, A., Neher, A., Feldmann, K., Mollenkopf, H.J., Ziegler, A., Kaufmann, S.H., Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med 85 (2007), 613–621.
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23 Mistry, R., Cliff, J.M., Clayton, C.L., Beyers, N., Mohamed, Y.S., Wilson, P.A., Dockrell, H.M., Wallace, D.M., van Helden, P.D., Duncan, K., et al. Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis. J Infect Dis 195 (2007), 357–365.
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24 Kim, D.K., Park, G.M., Hwang, Y.I., Kim, H.J., Han, S.K., Shim, Y.S., Yim, J.J., Microarray analysis of gene expression associated with extrapulmonary dissemination of tuberculosis. Respirology 11 (2006), 557–565.
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25
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77955894773
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An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
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This manuscript was the first to describe a blood transcriptional profile of active tuberculosis that was absent in latent disease, demonstrating an interferon-inducible signature of active tuberculosis which correlated with the extent of lung radiographic disease and was diminished upon treatment.
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25•• Berry, M.P., Graham, C.M., McNab, F.W., Xu, Z., Bloch, S.A., Oni, T., Wilkinson, K.A., Banchereau, R., Skinner, J., Wilkinson, R.J., et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466 (2010), 973–977 This manuscript was the first to describe a blood transcriptional profile of active tuberculosis that was absent in latent disease, demonstrating an interferon-inducible signature of active tuberculosis which correlated with the extent of lung radiographic disease and was diminished upon treatment.
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Nature
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Berry, M.P.1
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26
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78751648792
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26 Maertzdorf, J., Repsilber, D., Parida, S.K., Stanley, K., Roberts, T., Black, G., Walzl, G., Kaufmann, S.H., Human gene expression profiles of susceptibility and resistance in tuberculosis. Genes Immun 12 (2011), 15–22.
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27
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80055042377
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Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis
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This study confirms the reproducibility of the characteristic interferon-inducible blood transcriptional signature of human TB, validating earlier findings despite the use of different microarray platforms, blood collection and processing.
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27•• Maertzdorf, J., Ota, M., Repsilber, D., Mollenkopf, H.J., Weiner, J., Hill, P.C., Kaufmann, S.H., Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis. PLoS One, 6, 2011, e26938 This study confirms the reproducibility of the characteristic interferon-inducible blood transcriptional signature of human TB, validating earlier findings despite the use of different microarray platforms, blood collection and processing.
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PLoS One
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Maertzdorf, J.1
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28
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Transcriptional responses of host peripheral blood cells to tuberculosis infection
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28 Lesho, E., Forestiero, F.J., Hirata, M.H., Hirata, R.D., Cecon, L., Melo, F.F., Paik, S.H., Murata, Y., Ferguson, E.W., Wang, Z., et al. Transcriptional responses of host peripheral blood cells to tuberculosis infection. Tuberculosis (Edinb) 91 (2011), 390–399.
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Lesho, E.1
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29
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84866686896
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Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis
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This study also validates the characteristic interferon-inducible blood transcriptional signature in human TB, but also importantly identifies common interferon-inducible responses in the lungs of infected mice and in infected human macrophages.
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29•• Ottenhoff, T.H., Dass, R.H., Yang, N., Zhang, M.M., Wong, H.E., Sahiratmadja, E., Khor, C.C., Alisjahbana, B., van Crevel, R., Marzuki, S., et al. Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis. PLoS One, 7, 2012, e45839 This study also validates the characteristic interferon-inducible blood transcriptional signature in human TB, but also importantly identifies common interferon-inducible responses in the lungs of infected mice and in infected human macrophages.
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PLoS One
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Ottenhoff, T.H.1
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30
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Common patterns and disease-related signatures in tuberculosis and sarcoidosis
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This study is the first to perform a direct comparison of blood transcriptional profiles from patients with TB and Sarcoidosis and to identify common and distinct signatures.
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30•• Maertzdorf, J., Weiner, J. 3rd, Mollenkopf, H.J., Bauer, T., Prasse, A., Muller-Quernheim, J., Kaufmann, S.H., Common patterns and disease-related signatures in tuberculosis and sarcoidosis. Proc Natl Acad Sci U S A 109 (2012), 7853–7858 This study is the first to perform a direct comparison of blood transcriptional profiles from patients with TB and Sarcoidosis and to identify common and distinct signatures.
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Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis
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31 Remoli, M.E., Giacomini, E., Lutfalla, G., Dondi, E., Orefici, G., Battistini, A., Uze, G., Pellegrini, S., Coccia, E.M., Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis. J Immunol 169 (2002), 366–374.
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Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
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32 Chaussabel, D., Semnani, R.T., McDowell, M.A., Sacks, D., Sher, A., Nutman, T.B., Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood 102 (2003), 672–681.
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33
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Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
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33 Tailleux, L., Waddell, S.J., Pelizzola, M., Mortellaro, A., Withers, M., Tanne, A., Castagnoli, P.R., Gicquel, B., Stoker, N.G., Butcher, P.D., et al. Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages. PLoS One, 3, 2008, e1403.
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An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection
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34 Wu, K., Dong, D., Fang, H., Levillain, F., Jin, W., Mei, J., Gicquel, B., Du, Y., Wang, K., Gao, Q., et al. An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection. PLoS One, 7, 2012, e38367.
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35 Bouchonnet, F., Boechat, N., Bonay, M., Hance, A.J., Alpha/beta interferon impairs the ability of human macrophages to control growth of Mycobacterium bovis BCG. Infect Immun 70 (2002), 3020–3025.
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