Structure and activity of a new low-molecular-weight heparin produced by enzymatic ultrafiltration

Journal of Pharmaceutical Sciences

Volumn 103, Issue 5, 2014, Pages 1375-1383

  Fu, Li ^a   Zhang, Fuming ^c   Li, Guoyun ^b,d   Onishi, Akihiro ^b   Bhaskar, Ujjwal ^c   Sun, Peilong ^a   Linhardt, Robert J ^b,c,e  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c Rensselaer Polytechnic Institute   (United States)

^d OCEAN UNIVERSITY OF CHINA   (China)

^e RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

anticoagulant; enzymes; heparin lyase; low molecular weight heparin; mass spectrometry; NMR; polymeric drugs; structure activity relationship; surface plasmon resonance; ultrafiltration

Indexed keywords

ANTITHROMBIN III; DALTEPARIN; ENOXAPARIN; HEPARIN; HEPARIN LYASE; HEPARIN LYASE II; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; OLIGOSACCHARIDE; POLYSACCHARIDE; THROMBOCYTE FACTOR 4; TINZAPARIN; UNCLASSIFIED DRUG; DISACCHARIDE;

ANTICOAGULATION; ARTICLE; BINDING AFFINITY; CATALYST; CHEMICAL COMPOSITION; DEPOLYMERIZATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ULTRAFILTRATION; HUMAN; IN VITRO STUDY; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION; ULTRAFILTRATION; CHEMISTRY; PROCEDURES;

DISACCHARIDES; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; MOLECULAR WEIGHT; ULTRAFILTRATION;

EID: 84898016899     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23939     Document Type: Article

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