Heparinase 1 selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-a-D- glucopyranose (1,4) 2-O-sulfo-a-Lidopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages

Glycobiology

Volumn 21, Issue 1, 2011, Pages 13-22

  Xiao, Zhongping ^a,b   Zhao, Wenjing ^b   Yang, Bo ^b   Zhang, Zhenqing ^b   Guan, Huashi ^a   Linhardt, Robert J ^b,c  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b Department of Chemistry and Chemical Biology ^*  (United States)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Antithrombin III; Enzyme specificity; Heparin; Heparin lyase; Oligosaccharide structure

Indexed keywords

ANTITHROMBIN III; HEPARIN LYASE; HEPARINASE 1; OLIGOSACCHARIDE; SULFATE; UNCLASSIFIED DRUG;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BINDING SITE; DEPOLYMERIZATION; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; FLAVOBACTERIUM; GEL ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE MUCOSA; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN MOTIF; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTITHROMBIN III; BINDING SITES; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; HEPARIN; HEPARIN LYASE; OLIGOSACCHARIDES; URONIC ACIDS;

ESCHERICHIA COLI; PEDOBACTER HEPARINUS; SUS;

EID: 78751669651     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwq123     Document Type: Article

References (26)

1. Capila I, Linhardt RJ. 2002. Heparin-protein interactions. Angew Chem Int Ed. 41:390-412 [Angew Chem. 114: 426-450].
2. Cohen DM, Linhardt RJ. 1990. Randomness in the heparin polymer: computer simulations of alternative action patterns of heparin lyase. Biopolymers. 30:733-741.
3. Desai UR, Wang HM, Linhardt RJ. 1993a. Specificity studies on the heparin lyases from Flavobacterium heparinum. Biochemistry. 32:8140-8145. (Pubitemid 23265801)
4. Desai UR, Wang HM, Linhardt RJ. 1993b. Substrate specificity of the heparin lyases from Flavobacterium heparinum. Arch Biochem Biophys. 306:461-468. (Pubitemid 23314473)
5. Ernst S, Rhomberg AJ, Biemann K, Sasisekharan R. 1998. Direct evidence for a predominantly exolytic processive mechanism for depolymerization of heparin-like glycosaminoglycans by heparinase 1. Proc Natl Acad Sci USA. 95:4182-4187. (Pubitemid 28207885)
6. Goddard TD, Kneller DG. 2001. SPARKY. 3rd ed. San Francisco (CA): University of California.
7. Guerrini M, Beccati D, Shriver Z, Naggi AM, Bisio A, Capila I, Lansing J, Guglieri S, Fraser B, Al-Hakim A, et al. 2008. Oversulfated chondroitin sulfate is a major contaminant in heparin associated with adverse clinical events. Nat Biotechnol. 26:669-775.
8. Guerrini M, Zhang Z, Shriver Z, Masuko S, Langer R, Casu B, Linhardt RJ, Torri G, Sasisekharan R. 2009. Orthogonal analytical approaches to detect potential contaminants in heparin. Proc Natl Acad Sci USA. 106:16956-16961.
9. Jandik KA, Gu K, Linhardt RJ. 1994. Action pattern of polysaccharide lyases on glycosaminoglycans. Glycobiology. 4:289-296. (Pubitemid 24217245)
10. Linhardt RJ. 1992. Chemical and enzymatic methods for the depolymerization and modification of heparin. In: Ogura H, Hasegawa A, Suami T, editors. Carbohydrates-synthetic methods and applications in medicinal chemistry. Chap. 20. Tokyo/Weinheim: Kodansha/VCH Publishers. p. 387-403.
11. Linhardt RJ. 2003. Perspective: 2003 Claude S. Hudson Award Address in carbohydrate chemistry. Heparin: Structure and Activity. J Med Chem. 46:2551-2554.
12. Linhardt RJ, Fitzgerald GL, Cooney CL, Langer R. 1982. Mode of action of heparin lyase on heparin. Biochim Biophys Acta. 702:197-203. (Pubitemid 12088993)
13. Linhardt RJ, Gunay NS. 1999. Production and chemical processing of low molecular weight heparins. Semin Thromb Hemost. 25:5-16. (Pubitemid 29517028)
14. Linhardt RJ, Wang HM, Loganathan, Bae JH. 1992. Search for the heparin antithrombin III-binding site precursor. J Biol Chem 267:2380-2387.
15. Lohse DL, Linhardt RJ. 1992. Purification and characterization of heparin lyases from Flavobacterium heparinum. J Biol Chem. 267:24347-24355.
16. Ly M, Laremore TN, Linhardt RJ. 2010. Proteoglycomics: recent progress and future challenges. Omics 14:389-399.
17. Pervin A, Gallo C, Jandik KA, Han X, Linhardt RJ. 1995. Preparation and structural characterization of large heparin-derived oligosaccharides. Glycobiology. 5:83-95.
18. Rice KG, Rottink MK, Linhardt RJ. 1987. Fractionation of heparin-derived oligosaccharides by gradient polyacrylamide-gel electrophoresis. Biochem J. 244:515-522.
19. Shively JE, Conrad HE. 1976. Formation of anhydrosugars in the chemical depolymerization of heparin. Biochemistry 15:3932-3942.
20. Shriver Z, Sundaram M, Venkataraman G, Fareed J, Linhardt RJ, Biemann K, Sasisekharan R. 2000. Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin. Proc Natl Acad Sci USA. 97:10365-10370.
21. Thanawiroon C, Rice KG, Toida T, Linhardt RJ. 2004. LC/MS sequencing of highly sulfated heparin-derived oligosaccharides. J Biol Chem. 279:2608-2615.
22. Volpi N, Linhardt RJ. 2010. High performance liquid chromatography-mass spectrometry for mapping and sequencing glycosaminoglycan-derived oligosaccharides. Nat Protoc. 5:993-1004.
23. Yamada S, Sakamoto K, Tsuda H, Yoshida K, Sugahara K, Khoo KH, Morris HR, Dell A. 1994. Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substrates. Glycobiology. 4:69-78. (Pubitemid 24060518)
24. Yang HO, Gunay NS, Toida T, Kuberan B, Yu G, Kim YS, Linhardt RJ. 2000. Preparation and structural determination of dermatan sulfate-derived oligosaccharides. Glycobiology. 10:1033-1039.
25. Zhang Z, Xie J, Liu J, Linhardt RJ. 2008. Tandem MS can distinguish hyaluronic acid from N-acetylheparosan. J Am Soc Mass Spectrom. 19:82-90.
26. Zhang Z, Xie J, Liu H, Liu J, Linhardt RJ. 2009. Quantification of heparan sulfate and heparin disaccharides using ion-pairing, reverse-phase, microflow, high performance liquid chromatography coupled with electrospray ionization trap mass spectrometry. Anal Biochem. 81:4349-4355.