Enhanced antitumor efficacy by d -glucosamine-functionalized and paclitaxel-loaded poly(ethylene glycol)-co-poly(trimethylene carbonate) polymer nanoparticles

Journal of Pharmaceutical Sciences

Volumn 103, Issue 5, 2014, Pages 1487-1496

  Jiang, Xinyi ^a,b   Xin, Hongliang ^c   Gu, Jijin ^a   Du, Fengyi ^b   Feng, Chunlai ^b   Xie, Yike ^a   Fang, Xiaoling ^a  

^a FUDAN UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

biodegradable; biomaterials; cancer chemotherapy; d Glucosamine; drug delivery system; GLUT; nanoparticles; paclitaxel; polymers; tumor targeting delivery system

Indexed keywords

COPOLYMER; CYCLOPROPANE DERIVATIVE; GLUCOSAMINE; GLUCOSE TRANSPORTER; MACROGOL; NANOCARRIER; PACLITAXEL; POLY(ETHYLENE GLYCOL) CO POLY(TRIMETHYLENE CARBONATE); UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DIOXANE DERIVATIVE; EMULSION; MACROGOL DERIVATIVE; NANOPARTICLE; POLYMER; POLYTRIMETHYLENE CARBONATE; SOLVENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER INHIBITION; CANCER TISSUE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG TARGETING; DRUG TISSUE LEVEL; EMULSION; ENDOCYTOSIS; EVAPORATION; FLUORESCENCE IMAGING; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN RESIDENCE TIME; MORPHOLOGY; MOUSE; NANOFABRICATION; NONHUMAN; PARTICLE SIZE; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; TUMOR SPHEROID; TUMOR XENOGRAFT; ZETA POTENTIAL; ANIMAL; CHEMISTRY; METABOLISM; NEOPLASMS; PHARMACOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DIOXANES; DRUG DELIVERY SYSTEMS; EMULSIONS; ENDOCYTOSIS; GLUCOSAMINE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; MALE; MICE; NANOPARTICLES; NEOPLASMS; PACLITAXEL; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS;

EID: 84898007670     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23928     Document Type: Article

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